Abstract: A container for handling and transporting temperature-sensitive items. The container includes a tote made of a resilient material, the tote including an opening for inserting items and flaps for covering the opening, wherein the tote has dimensions compatible with commercial product-handling equipment. The container further includes a liner sized to fit into the tote. In one embodiment, the liner includes a shell made of a resilient material and shaped to cover the interior surfaces of the tote. The liner has a layer of a temperature insulating material enclosed within the shell. A liner is lid sized to fit securely over the opening of the shell, and in one embodiment, includes a layer of the insulating material and a cavity for inserting a refrigerant material therein.