Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.
Type:
Grant
Filed:
June 3, 2003
Date of Patent:
November 16, 2004
Assignee:
Wellspring Pharmaceutical Corporation
Inventors:
Robert A. Vukovich, Benjamin Levinson, George S. Drummond, Robert Caroselli, Kazimierz G. Antczak, Christopher Boucher, Richard Mortimer
Abstract: A method of preparing metal mesoporphyrin halide compounds is described. The metal mesoporphyrin halide compound may be formed by forming a novel mesoporphyrin IX intermediate compound and then converting the mesoporphyrin IX intermediate to the metal mesoporphyrin halide through metal insertion. The novel intermediate compound may be formed by a catalytic hydrogenation of hemin in acid and subsequent recovery.
Type:
Application
Filed:
March 29, 2004
Publication date:
October 21, 2004
Applicant:
WellSpring Pharmaceutical Corporation
Inventors:
Robert Vukovich, Benjamin Levinson, George S. Drummond, Robert Caroselli, Kazimierz G. Antczak, Christopher Boucher, Richard Mortimer, Danny Levin, Keith A. Cooke