Abstract: The present invention relates to antibodies targeting the membrane bound IgM (mIgM) of the B-cell receptor complex found in B-cell lymphomas and leukemias and uses thereof. Another aspect of the present invention is the use of anti-B-Cell mIgM antibodies in the treatment of Be-cell malignancies, including B-cell lymphomas and leukemias.
Type:
Grant
Filed:
February 13, 2018
Date of Patent:
March 12, 2019
Assignee:
Welt Bio-Molecular Pharmaceutical, LLC.
Inventors:
Sydney Welt, David Kostyal, Rachel S Welt, Virginia Raymond, Jonathan A Welt
Abstract: The present invention relates to monoclonal antibodies targeting the membrane bound IgM (mIgM) of the B-cell receptor complex found in B-cell lymphomas and leukemias. Monoclonal antibodies designated mAb4-2b, mAb1-1, mAb2-2b and mAb3-2b were produced by hybridoma cell lines (ATCC deposit no. PTA-121716), (ATCC deposit no. PTA-121719), (ATCC deposit no. PTA-121717), and (ATCC deposit no. PTA-121718), respectively. Another aspect of the present invention is the use of anti-B-Cell mIgM antibodies in the treatment of B-cell malignancies, including B-cell lymphomas and leukemias.
Type:
Grant
Filed:
December 1, 2014
Date of Patent:
March 27, 2018
Assignee:
WELT BIO-MOLECULAR PHARMACEUTICAL, LLC.
Inventors:
Sydney Welt, David Kostyal, Rachel S Welt, Virginia Raymond, Jonathan A Welt