Patents Assigned to Wenkart Foundation
  • Therapeutic and diagnostic molecules
    Patent number: 9320755
    Abstract: The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: April 26, 2016
    Assignees: CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY, UNIVERSITY OF SYDNEY, WENKART FOUNDATION
    Inventors: Jennifer Gamble, Mathew Vadas, Gregory Goodall, Jennifer Young
  • Therapeutic and Diagnostic Molecules
    Publication number: 20120196925
    Abstract: The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.
    Type: Application
    Filed: June 4, 2010
    Publication date: August 2, 2012
    Applicants: Centenary Institute of Cancer Medicine and Cell Biology, Wenkart Foundation, Medvet Science Pty Ltd., University of Sydney
    Inventors: Jennifer Gamble, Mathew Vadas, Gregory Goodall, Jennifer Young