Abstract: Disclosed is a high anticoagulation extracorporeal circulation tube, which include the following preparation methods: S1, firstly, aminating the surface of the tube by extrusion molding; S2, activating heparin groups by a direct coupling method; S3, heparinizing PVC or PC tubes; S4, then, using albumin, functionalized PEG which can react with amino groups, and phosphate to further surface modify the inner wall of heparinized PVC or PC tube to block the sites not modified by heparinization, so as to shield the adsorption of platelets and protein in blood on the inner wall. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.
Type:
Application
Filed:
September 20, 2022
Publication date:
February 29, 2024
Applicant:
Wenzhou Safety (Emergency) Research Institute, Tianjin University
Inventors:
Bin ZHENG, Haojun FAN, Bowen LI, Tingting HUA
Abstract: Disclosed is a high anticoagulation ECMO and extracorporeal circulation consumable, which include the following preparation methods: S1, aminating the surface of ECMO blood circulation device and extracorporeal circulation consumables; S2, activating heparin groups; S3, heparinizing the ECMO blood circulation device and extracorporeal circulation consumables; S4, modification of enhancer. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.
Type:
Application
Filed:
September 20, 2022
Publication date:
February 29, 2024
Applicant:
Wenzhou Safety (Emergency) Research Institute, Tianjin University
Inventors:
Bin ZHENG, Haojun FAN, Bowen LI, Tingting HUA
Abstract: Disclosed is a high anticoagulation extracorporeal circulation tube, which include the following preparation methods: S1, firstly, aminating the surface of the tube by extrusion molding; S2, activating heparin groups by a direct coupling method; S3, heparinizing PVC or PC tubes; S4, then, using albumin, functionalized PEG which can react with amino groups, and phosphate to further surface modify the inner wall of heparinized PVC or PC tube to block the sites not modified by heparinization, so as to shield the adsorption of platelets and protein in blood on the inner wall. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.
Type:
Grant
Filed:
September 20, 2022
Date of Patent:
February 6, 2024
Assignee:
Wenzhou Safety (Emergency) Research Institute, Tianjin University
Inventors:
Bin Zheng, Haojun Fan, Bowen Li, Tingting Hua