Patents Assigned to West China Hospital Sichuan University
  • Patent number: 10611771
    Abstract: The present invention discloses pyrazolo[3,4-d]pyrimidine derivatives of formula (I). Compounds provided in the present invention have significant inhibitory effects on tumor cells, can be used for the prevention and/or treatment of tumor-related diseases, especially lung cancer, and have wide application prospects.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: April 7, 2020
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Yang He, Weimin Li, Li Zhang, Bojiang Chen, Zhixin Qiu
  • Patent number: 10506747
    Abstract: A mouse for magnetic resonance, comprising an upper shell (1), a lower shell (2), a trackball (3), a circuit board (4) and a cable (5), wherein the inner surfaces of the upper shell (1) and the lower shell (2) are coated with a silver and copper conductive paint layer, the concentration of a silver and copper conductive paint being 13% to 17%; and a manufacturing method for the mouse for magnetic resonance, and a signal transmission apparatus are further comprised. The clinical usage of functional magnetic resonance can be satisfied, a signal interference is avoided, and it is ensured that a remote computer accurately receives a response of a subject.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: December 10, 2019
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Qiyong Gong, Huaiqiang Sun, Lefeng Ren, Haoyang Xing, Jie Tang, Xiaoqi Huang, Youjin Zhao
  • Patent number: 10428132
    Abstract: The present invention discloses a tumor necrosis factor-related apoptosis-inducing ligand variant, which is a fusion protein of a tumor necrosis factor-related apoptosis-inducing ligand and an F3 peptide. The F3 peptide is fused to the N-terminus or C-terminus of the tumor necrosis factor-related apoptosis-inducing ligand by a linker. The present invention also discloses a nucleotide sequence, as well as a recombinant vector and a recombinant bacterium comprising same, and also discloses a preparation method and use of the foregoing variant.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: October 1, 2019
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: XiaoFeng Lu, Hao Yang, Lin Wan, JingQiu Cheng
  • Patent number: 10011562
    Abstract: The present invention relates to long-chain dimethylaniline derivative compounds, their preparation methods, self-assembled texture, and uses thereof. Said compounds show ultralong acting anaesthetic effect, and belong to N-diethylaminoacetyl-2,6-dimethylaniline compounds, having a structure according to formula (I). Said compounds may self-assemble into micelle or gel in an aqueous solvent, and exert an in vivo elongated local anesthetic actions. Local anesthesia and/or analgesic activity can last more than 72 hours. The biomaterials can self-assemble into micelles or gels in water and have local anesthetic effect, as well as can further be used as the coating of medicinal bioactive molecules for treatment of pain, itching and the like and/or the drug carriers, together with as pharmaceutical adjuvants for delivery system. Thus, said materials have a favorable perspective.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: July 3, 2018
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Lei Tang, Jin Liu, Wensheng Zhang, Jun Yang, Bowen Ke, Qinqin Yin
  • Patent number: 9969695
    Abstract: The present invention relates to an N-substituted imidazole carboxylic ester chiral compound containing an ether side chain and to its preparation and application. The structure of this compound is represented by Formula (I). This compound can induce a rapid and reversible general anesthesia effect. Animal experiments show that this compound has rapid and short-acting pharmacological characteristics, so that it can be used as a rapid and short-acting general anesthesia medicine. Compared with etomidate, this compound can reduce the inhibition on the synthesis of adrenal cortical hormone, with an advantage of rapid and full recovery of the post-operative patient. The only chiral carbon in the compound structure belongs to the R form.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: May 15, 2018
    Assignee: WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
    Inventors: Wensheng Zhang, Jun Yang, Jin Liu, Lei Tang, Bowen Ke
  • Patent number: 9272978
    Abstract: Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y?C1-4 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: March 1, 2016
    Assignee: West China Hospital, Sichuan University
    Inventors: Wensheng Zhang, Jun Yang, Jin Liu
  • Patent number: 9243009
    Abstract: Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y?C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: January 26, 2016
    Assignees: West China Hospital, Sichuan University, Yichang Humanwell Pharmaceutical Co., Ltd.
    Inventors: Wensheng Zhang, Jun Yang, Jin Liu
  • Patent number: 9186421
    Abstract: Use of low dose streptozocin in the preparation of an animal model for screening drugs for treatment of antoimmune type 1 diabetes is disclosed, in which streptozocin is administrated intravenously at a dose of 15-30 mg/kg per time for 5 days and administrated again on the 7th day and 14th day after last time of offering drug. A method for preparing rhesus monkey model of autoimmune type 1 diabetes and autoimmune type 1 diabetes animal model obtained are also disclosed.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: November 17, 2015
    Assignee: West China Hospital, Sichuan University
    Inventors: Yanrong Lu, Jingqiu Cheng, Shaoping Deng, Younan Chen, Bole Tian, Gang Mai, Yan Ren, Li Wang, Hongxia Li, Lingling Wei, Xi Jin, Chaofeng Qiao, Wensheng Zhang, Sirong He, Li Zeng
  • Publication number: 20130149733
    Abstract: Use of low dose streptozocin in the preparation of an animal model for screening drugs for treatment of antoimmune type 1 diabetes is disclosed, in which streptozocin is administrated intravenously at a dose of 15-30 mg/kg per time for 5 days and administrated again on the 7th day and 14th day after last time of offering drug. A method for preparing rhesus monkey model of autoimmune type 1 diabetes and autoimmune type 1 diabetes animal model obtained are also disclosed.
    Type: Application
    Filed: March 26, 2010
    Publication date: June 13, 2013
    Applicant: West China Hospital, Sichuan University
    Inventors: Yanrong Lu, Jingqiu Cheng, Shaoping Deng, Younan Chen, Bole Tian, Gang Mai, Yan Ren, Li Wang, Hongxia Li, Lingling Wei, Xi Jin, Chaofeng Qiao, Wensheng Zhang, Sirong He, Li Zeng
  • Publication number: 20130085120
    Abstract: Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y=C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.
    Type: Application
    Filed: October 13, 2010
    Publication date: April 4, 2013
    Applicants: Yichang Humanwell Pharmaceutical Co., Ltd., West China Hospital, Sichuan University
    Inventors: Wensheng Zhang, Jun Yang, Jin Liu
  • Publication number: 20130079405
    Abstract: Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y?C14 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.
    Type: Application
    Filed: October 13, 2010
    Publication date: March 28, 2013
    Applicant: West China Hospital Sichuan University
    Inventors: Wensheng Zhang, Jun Yang, Jin Liu