Abstract: Adhesive material from the fimbriae (esp. Type 1) of bacteria or synthetic analogues or fragments thereof is combined with a drug to provide for attachment to the gut of a mammal, thereby prolonging the transit time of the drug through the gut. The 28 kDa polypeptide from E. coli Type 1 fimbriae is the preferred adhesive material (“adhesin”). The drug is presented in a carrier such as albumin, a polylactide/glycolide copolymer or alginate microcapsules. The adhesin may be incorporated in the carrier during preparation thereof, adsorbed onto the carrier after preparation, or covalently linked thereto, for example with carbodiimide.
Type:
Grant
Filed:
April 28, 1994
Date of Patent:
March 12, 2002
Assignee:
West Pharmacuetical Services Drug Delivery &
Clinical
Inventors:
Lisbeth Illum, Paul Williams, Antony James Caston