Patents Assigned to Westwood Pharmaceuticals, Inc.
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Patent number: 4375545Abstract: 6-Aminonicotinic acid is reacted with an alkali carbonate selected from the group consisting of sodium carbonate and potassium carbonate. The reaction is carried out at elevated temperature and in dimethylformamide. The 6-aminonicotinic acid alkali salt so produced is reacted with 3-chloromethylpyridine hydrochloride. The reaction is carried out at elevated temperature and in dimethylformamide. The desired nicotinyl ester is thus produced.Type: GrantFiled: June 22, 1981Date of Patent: March 1, 1983Assignee: Westwood Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr., William A. Somerville, F. Christopher Zusi
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Patent number: 4355028Abstract: Procedure for treating acne vulgaris that uses salicylic acid and benzoyl peroxide either sequentially or simultaneously. Compositions for practicing each of these aspects of the invention are also described.Type: GrantFiled: April 30, 1981Date of Patent: October 19, 1982Assignee: Westwood Pharmaceuticals, Inc.Inventors: Albert M. Kligman, Walter L. McKenzie, Peter F. Ciesla
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Patent number: 4318907Abstract: Procedure for treating acne vulgaris that uses salicylic acid and benzoyl peroxide either sequentially or simultaneously. Compositions for practicing each of these aspects of the invention are also described.Type: GrantFiled: April 4, 1978Date of Patent: March 9, 1982Assignee: Westwood Pharmaceuticals, Inc.Inventors: Albert M. Kligman, Walter L. McKenzie, Peter F. Ciesla
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Patent number: 4315023Abstract: 1-Phenethylimidazole compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen or halogen, Z is a mono or disubstituted phenyl moiety of the formula: ##STR2## or a 2 or 3-thienyl moiety of formula: ##STR3## wherein R.sup.3 and R.sup.4 are independently hydrogen, halogen, (lower) alkyl, or trifluoromethyl, with the proviso that R.sup.3 and R.sup.4 can not both be trifluoromethyl and the antimicrobial acid addition salts thereof are useful as antifungal and antibacterial agents.Type: GrantFiled: December 1, 1980Date of Patent: February 9, 1982Assignee: Westwood Pharmaceuticals, Inc.Inventors: Richard A. Partyka, Thomas W. Hudyma
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Patent number: 4282206Abstract: Reaction of 4-nitrophenacyl bromide with morpholine affords the novel intermediate 1-(4-nitrophenyl)-2-morpholinylethanone which when reduced yields the novel sunscreen 1-(4-aminophenyl)-2-morpholinylethanone.Type: GrantFiled: November 15, 1979Date of Patent: August 4, 1981Assignee: Westwood Pharmaceuticals Inc.Inventors: Paul L. Warner, Jr., F. Christopher Zusi
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Patent number: 4236015Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.5 is a cycloaliphatic, phenyl, substituted phenyl group bonded to the carbonyl carbon through a carbon-to-carbon linkage are intermediates for the preparation of 4-substituted imidazo[1,2-a]quinoxalines having anti-inflammatory, immunosuppressant and anti-fungal activity.Type: GrantFiled: May 7, 1979Date of Patent: November 25, 1980Assignee: Westwood Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4229452Abstract: A method for treating inflammatory disorders in mammals which comprises administering to said mammals having an inflammatory disorder a therapeutically effective amount of 4-trifluoromethylimidazo[1,2-a]quinoxaline.Type: GrantFiled: July 12, 1979Date of Patent: October 21, 1980Assignee: Westwood Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4225724Abstract: 2(1-imidazolyl)phenylureylene compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic groups are intermediates for the preparation of 4-substituted amino imidazo[1,2-a]quinoxalines having immunosuppressant activity.Type: GrantFiled: March 5, 1979Date of Patent: September 30, 1980Assignee: Westwood Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4200750Abstract: A 4-substituted imidazo [1,2-a]quinoxaline of formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is bonded to a ring carbon through a carbon-to-carbon linkage and is an aliphatic, cycloaliphatic, substituted phenyl, fused bicyclic aryl; or a monocyclic aryl substituted aliphatic group.Type: GrantFiled: December 8, 1977Date of Patent: April 29, 1980Assignee: Westwood Pharmaceuticals Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4198508Abstract: Preparation of 4-substituted imidazo[1,2-a]quinoxalines by cyclizing a compound of the formula: ##STR1## with phosphorous oxychloride wherein X.sup.2 is a group --R.sup.5 or --NHR.sup.2 where R.sup.5 and R.sup.2 are hydrogen or various organo groups.Type: GrantFiled: December 8, 1977Date of Patent: April 15, 1980Assignee: Westwood Pharmaceuticals Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4197403Abstract: A 4-substituted imidazo[1,2-a]quinoxaline of formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.2 is hydrogen or a radical bonded to the nitrogen by a carbon to nitrogen linkage and selected from the group consisting of aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl, and monocyclic aryl substituted aliphatic group.Type: GrantFiled: December 8, 1977Date of Patent: April 8, 1980Assignee: Westwood Pharmaceuticals Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4191766Abstract: A method for reducing the immunological response in mammals by the administration of certain substituted phenyl or substituted anilino imidazo[1,2-a]quinoxalines.Type: GrantFiled: December 8, 1977Date of Patent: March 4, 1980Assignee: Westwood Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4191767Abstract: A method for treating a fungal infection in mammals which comprises administering to said mammals having a fungal infection a therapeutically effective amount of a 4-(substituted phenyl)imidazo[1,2-a]quinoxaline.Type: GrantFiled: December 8, 1977Date of Patent: March 4, 1980Assignee: Westwood Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4185108Abstract: It is disclosed that compounds of the formula: ##STR1## wherein Y represents (C.dbd.O).sub.m in which m has a value of 0 or 1; n has a value of 0 or 1; and X represents S, NH or O; provided that there is a COOH substituent at the 1, 2 or 3 position relative to the X group; and further provided that when X is NH and n is O, the COOH group cannot be at the 2 position; or a nontoxic, pharmaceutically acceptable salt thereof are capable of decreasing the ratio of the rates of bone resportion to bone deposition in a host animal, e.g., in the treatment of osteoporosis.Type: GrantFiled: September 15, 1978Date of Patent: January 22, 1980Assignee: Westwood Pharmaceuticals Inc.Inventors: Carlos M. Samour, Julius A. Vida
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Patent number: 4172947Abstract: A 1-(2-acylaminophenyl)imidazole of formula: ##STR1## wherein R.sup.5 is hydrogen or an aliphatic, cycloaliphatic, phenyl, substituted phenyl, fused bicyclic aryl or monocyclic aryl substituted aliphatic group bonded to the carbonyl carbon through a carbon-to-carbon linkage. The compounds are useful as intermediates in the preparation of 4-substituted imidazo[1,2-a]quinoxalines.Type: GrantFiled: December 8, 1977Date of Patent: October 30, 1979Assignee: Westwood Pharmaceuticals, Inc.Inventors: Paul L. Warner, Jr., Edward J. Luber, Jr.
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Patent number: 4172149Abstract: Treats living skin in which sebum secretion is excessive with certain triglycerides to reduce the level of sebum secretion.Type: GrantFiled: January 30, 1978Date of Patent: October 23, 1979Assignee: Westwood Pharmaceuticals, Inc.Inventors: Jeffrey S. Pinto, Sung L. Hsia, Paul L. Warner, Jr.
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Patent number: 4102995Abstract: A tar formulation used in the treatment of skin disorders containing tar, propylene glycol, ethyl alcohol and a gelling agent e.g. Carbopol 940.Type: GrantFiled: May 13, 1976Date of Patent: July 25, 1978Assignee: Westwood Pharmaceuticals Inc.Inventor: Peter Hebborn
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Patent number: 4000263Abstract: There is disclosed a storage stable solution comprising a solution of erythromycin, propylene glycol, ethyl alcohol, and an ethoxylated ether of lauryl alcohol. The solution possesses excellent stability at both room temperature and at elevated temperatures for prolonged periods of time.Type: GrantFiled: May 2, 1975Date of Patent: December 28, 1976Assignee: Westwood Pharmaceuticals, Inc.Inventor: Peter Hebborn
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Patent number: 3953589Abstract: The specification discloses 4-N,N-bis-(2-hydroxyethyl)aminoacylphenones which are useful as sunscreening agents for absorbing intermediate range radiation. The acyl moiety is derived from the group of alkanoic acids having from 2 to about 16 carbon atoms.Type: GrantFiled: September 27, 1974Date of Patent: April 27, 1976Assignee: Westwood Pharmaceuticals, Inc.Inventor: Paul L. Warner, Jr.
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Patent number: RE29653Abstract: The specification discloses 4-N,N-bis-(2-hydroxyethyl)aminoacylphenones which are useful as sunscreening agents for absorbing intermediate range radiation. The acyl moiety is derived from the group of alkanoic acids having from 2 to about 16 carbon atoms.Type: GrantFiled: August 16, 1976Date of Patent: May 30, 1978Assignee: Westwood Pharmaceuticals, Inc.Inventor: Paul L. Warner, Jr.