Patents Assigned to Wex Medical Limited
  • Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
    Patent number: 11419873
    Abstract: The present invention refers to the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for the production of a medicament for the treatment of neuropathic pain resulting from chemotherapy.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: August 23, 2022
    Assignee: WEX MEDICAL LIMITED
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela Hernandez, Jose Manuel Baeyens
  • USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY
    Publication number: 20210252004
    Abstract: The present invention refers to the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for the production of a medicament for the treatment of neuropathic pain resulting from chemotherapy.
    Type: Application
    Filed: February 10, 2020
    Publication date: August 19, 2021
    Applicant: Wex Medical Limited
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela Hernandez, Jose Manuel Baeyens
  • Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
    Patent number: 10624896
    Abstract: The present invention refers to the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for the production of a medicament for the treatment of neuropathic pain resulting from chemotherapy.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: April 21, 2020
    Assignee: Wex Medical Limited
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela Hernandez, Jose Manuel Baeyens
  • USE OF SODIUM CHANNEL BLOCKERS FOR THE TREATMENT OF NEUROPATHIC PAIN DEVELOPING AS A CONSEQUENCE OF CHEMOTHERAPY
    Publication number: 20190160074
    Abstract: The present invention refers to the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for the production of a medicament for the treatment of neuropathic pain resulting from chemotherapy.
    Type: Application
    Filed: January 31, 2019
    Publication date: May 30, 2019
    Applicant: Wex Medical Limited
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela Hernandez, Jose Manuel Baeyens
  • Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy
    Patent number: 9018222
    Abstract: The present invention refers to the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for the production of a medicament for the treatment of neuropathic pain resulting from chemotherapy.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: April 28, 2015
    Assignee: Wex Medical Limited
    Inventors: Helmut Heinrich Buschmann, Jose Miguel Vela Hernandez, Jose Manuel Baeyens
  • Stable pharmaceutical composition of freeze-dried tetrodotoxin powder
    Patent number: 8530481
    Abstract: This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: September 10, 2013
    Assignee: Wex Medical Limited
    Inventors: Weiyang Lin, Xiaoyan Huang, Xiao Zhang
  • Sodium channel blocking compounds tetrodotoxin galactopyranosides
    Patent number: 8486901
    Abstract: Novel sodium channel blocking compounds tetrodotoxm galactopyranosides of formula I were isolated and purified by HPLC and identified further through IR, NMR, GC, and MS. The compounds have a galactopyranosyl moiety attached to C11 of tetrodotoxin and retain the analgesic activity of the latter. Pharmaceutical compositions and medical uses thereof are further disclosed.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: July 16, 2013
    Assignee: Wex Medical Limited
    Inventor: Weiyang Lin
  • STABLE PHARMACEUTICAL COMPOSITION OF FREEZE-DRIED TETRODOTOXIN POWDER
    Publication number: 20120264767
    Abstract: This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.
    Type: Application
    Filed: June 26, 2012
    Publication date: October 18, 2012
    Applicant: WEX MEDICAL LIMITED
    Inventors: Weiyang Lin, Xiao Zhang, Xiaoyan Huang
  • Stable pharmaceutical composition of freeze-dried tetrodoxin powder
    Patent number: 8222258
    Abstract: This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: July 17, 2012
    Assignee: Wex Medical Limited
    Inventors: Weiyang Lin, Xiao Zhang, Xiaoyan Huang
  • Novel Sodium Channel Blocking Compounds Tetrodotoxin Galactopyranosides
    Publication number: 20120101054
    Abstract: Novel sodium channel blocking compounds tetrodotoxm galactopyranosides of formula I were isolated and purified by HPLC and identified further through IR, NMR, GC, and MS. The compounds have a galactopyranosyl moiety attached to C11 of tetrodotoxin and retain the analgesic activity of the latter. Pharmaceutical compositions and medical uses thereof are further disclosed.
    Type: Application
    Filed: March 26, 2010
    Publication date: April 26, 2012
    Applicant: Wex Medical Limited
    Inventor: Weiyang Lin
  • Stable pharmaceutical composition of freeze-dried tetrodotoxin powder
    Patent number: 8124608
    Abstract: This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: February 28, 2012
    Assignee: Wex Medical Limited
    Inventors: Xiao Zhang, Xiaoyan Huang, Weiyang Lin
  • STABLE PHARMACEUTICAL COMPOSITION OF FREEZE-DRIED TETRODOXIN POWDER
    Publication number: 20100249150
    Abstract: This invention relates to a stable pharmaceutical composition of freeze-dried tetrodotoxin powder which contains trace amount of tetrodotoxin, substances which can stabilizes tetrodotoxin, including disaccharide(s) or polyglucose(s) or analogues thereof and solvent(s), and solvents which can help tetrodotoxin dissolve.
    Type: Application
    Filed: December 31, 2009
    Publication date: September 30, 2010
    Applicant: WEX Medical Limited
    Inventors: Weiyang Lin, Xiao Zhang, Xiaoyan Huang
  • Use of Sodium Channel Blocking Compounds and Aspirin in Manufacturing Drugs for Producing Analgesia Synergistically in Mammals
    Publication number: 20090105197
    Abstract: This invention relates to the use of combinations of a sodium channel blocking compound that binds to an SSI or SS2 site of extracellular region of a sodium channel alpha subunit, and aspirin in manufacturing drugs for producing synergistically analgesic effect in mammals. Pharmaceutical compositions based upon this invention can enhance analgesic effect and reduce dosage of aspirin, therefore side effects and adverse reactions are decreased accordingly.
    Type: Application
    Filed: October 10, 2008
    Publication date: April 23, 2009
    Applicant: WEX MEDICAL LIMITED
    Inventors: Baoshan Ku, Hay Kong Shum