Abstract: A closure arrangement for pharmaceutical bottles contains a stopper closing the bottle mouth, and a closure cap mounted over the bottle mouth and a closure cap. The stopper is adapted to be pierced with a hollow needle for extracting a medicament located in the bottle. The closure cap is provided with a tear-off disc which is located above the stopper and is removable upon opening the closure. The tear-off disc is produced from plastic material in one piece with the closure cap and is retained thereat by means of a weakening line. Between the tear-off disc and the stopper there is provided a spacer which does not extend beyond the outline of the tear-off disc. The spacer is formed in one piece with the tear-off disc and/or with the stopper. The closure cap can be one-handedly pressed in the direction toward the bottle, whereby the tear-off disc is separated from the closure cap and the stopper is free for insertion of a hollow needle.