Abstract: The present invention relates to a composition of topical preparation containing alprostadil alkyl ester, and more particularly, comprising an alprostadil alkyl ester, an oily vehicle, a skin permeation enhancer and an anti-irritant agent.
Type:
Grant
Filed:
December 20, 2001
Date of Patent:
January 6, 2004
Assignee:
Whan In Pharm. Co., Ltd.
Inventors:
Dong Soo Lee, Kye Kwan Lee, Yun Seok Rhee, Jun Hee Jang, Sun Oh Jeoung, Sang Jin Kim, Sang Cheol Chi
Abstract: The present invention relates to a composition of topical preparation containing alprostadil alkyl ester, and more particularly, comprising an alprostadil alkyl ester, an oily vehicle, a skin permeation enhancer and an anti-irritant agent.
Type:
Application
Filed:
December 20, 2001
Publication date:
July 3, 2003
Applicant:
WHAN IN PHARM. CO., LTD.
Inventors:
Dong Soo Lee, Kye Kwan Lee, Yun Seok Rhee, Jun Hee Jang, Sun Oh Jeoung, Sang Jin Kim, Sang Cheol Chi
Abstract: The present invention relates to a composition of topical preparation containing alprostadil, which has excellent skin permeation rate with little skin irritation, which is prepared by dissolving alprostadil or a solid dispersion thereof prepared using poloxamer, into a mixture of an oily vehicle, a pyrrolidone and an anti-irritant agent.
Type:
Grant
Filed:
August 29, 2000
Date of Patent:
December 31, 2002
Assignee:
Whan In Pharm Co., Ltd.
Inventors:
Sang-Cheol Chi, Dong Soo Lee, Kye Kwan Lee