Patents Assigned to Whitehead Insti.
  • Nuclear factors associates with transcriptional regulation
    Patent number: 5804374
    Abstract: Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.
    Type: Grant
    Filed: April 6, 1995
    Date of Patent: September 8, 1998
    Assignees: Massachusetts Insti. Technology, Whitehead Insti., Pres. and Fellow of Harvard College
    Inventors: David Baltimore, Ranjan Sen, Phillip A. Sharp, Harinder Singh, Louis Staudt, Jonathan H. LeBowitz, Albert S. Baldwin, Jr., Roger G. Clerc, Lynn M. Corcoran, Patrick A. Baeuerle, Michael J. Lenardo, Chen-Ming Fan, Thomas P. Maniatis