Patents Assigned to Whitehead Institute for Miomedical Reasearch
  • MODULATORS OF ALPHA-SYNUCLEIN TOXICITY
    Publication number: 20110064722
    Abstract: Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
    Type: Application
    Filed: December 22, 2008
    Publication date: March 17, 2011
    Applicant: Whitehead Institute for Miomedical Reasearch
    Inventors: Susan L. Lindquist, Aaron D. Gitler