Abstract: Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed.
Type:
Application
Filed:
January 20, 2009
Publication date:
August 5, 2010
Applicant:
Whitehead Instutite for Biomedical Research
Inventors:
Michael J. Root, Michael S. Kay, David C. Chan, Peter S. Kim