Abstract: According to the present invention, there is provided a compound comprising the amino acid sequence AMVSE, wherein said compound does not comprise the amino acid sequence EQEYVQTV. Preferably the compound contains 5-11 amino acids. The compound is used in the manufacture of a medicament or pharmaceutical composition for inhibiting leukocyte migration, or treating or preventing inflammation and/or inflammatory response/disease from such conditions as gout, gouty arthritis, rheumatoid arthritis, asthma, reperfusion injury or damage, stroke, myocardial infarction, septic shock, or a skin disorder.

Abstract: Control of inflammation is achieved by control of the level and/or activity of the enzyme heme-oxygenase (HO). A HO inducer is anti-inflammatory (FIG. 14) and used to treat inflammation, such as chronic inflammatory diseases. A HO inhibitor promotes inflammation and is used to treat immunosuppressed conditions. Alternative, or additional, control of heme-oxygenase activity is achieved by control of nitric oxide levels, elevated levels promoting inflammation.