Abstract: A method of operating a device (10) for handling banknotes detects multi-sheet withdrawals using a multi-sheet withdrawal sensor (30). If a multi-sheet withdrawal has been detected, at least the banknotes of the multi-sheet withdrawal are supplied to an input and/or output tray (22). Next, the banknotes are further separated. The denomination and/or number of the banknotes of the multi-sheet withdrawal is determined. The determined number and/or denomination is taken into account in the framework of the inventory management of the cash cassettes (16).