Abstract: The present disclosure provides methods of preparing a medical solution. In some aspects, the medical solution can be prepared from mixing a first liquid with a second liquid or mixing a solid component with a liquid in an autoinjector. In some aspects, the heat released from the mixing can promote solubility of a dry medicament in the solution.

Abstract: A reciprocating medicament mixing and injector system, where the energy provided to transfer medicament components back and forth between containers or cartridges can be redirected to deliver the mixed medicament components. In one embodiment the energy source is a pressurized gas chamber, in another, it is constant force spring, and in another it is a compression spring.

Abstract: The invention provides pharmaceutical compositions comprising a dry medicament. The dry medicaments can be rapidly dissolved, solubilized, and/or reconstituted to deliver to a subject. The present invention provides methods of preparing a medical solution. The medical solution can be prepared from mixing the pharmaceutical composition as described herein with a first liquid.

Abstract: A mixing device configured to hold two containers, each having a separate medicament component disposed therein. A fluidic channel is provided that upon creating fluidic communication with each container once seals about each container are opened. Then a transfer mechanism can transfer the medicament components from one container to the other container until ready to be delivered or transferred through the fluidic channel through a delivery assembly.

Abstract: The present invention relates to a mixing and injector device which can include: a housing having a plurality of separate and distinct chambers disposed therein; one or more displacement mechanisms corresponding to each of the plurality of chambers disposed within the housing; a needle assembly being provided about one of the plurality of chambers, the needle assembly including the following: a septum; a needle being separated from the plurality of chambers by the septum, the needle having a proximal end configured to pierce the septum in an actuated state; and a needle carrier, the needle carrier being configured to translate axially with respect to and toward the septum and pierce the septum and provide fluid communication from the plurality of chambers through the needle in the actuated state.

Abstract: Contemplated herein is a medication mixing device which can include a housing having therein a first chamber containing a first medicament component and a second chamber provided containing a second medicament component provided with a sealing structure selectively isolating the first chamber from the second chamber. The sealing structure can include a first sealing component having a first sealing interface and a second sealing component having a second sealing interface wherein a first compression force can be applied to the first and second sealing components causes the sealing interfaces to form a seal. The first compression force can then be configured to allow the first sealing component and the second sealing component to maintain at least one degree of freedom with respect to one another.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: A component storage and nest system, the system including a tub having a lip portion provided on an interior surface of the tub; a primary nest having a plurality of receptacles in an upper surface, the upper surface having a flange portion about a perimeter being configured to engage the tub about the lip portion; and a plurality of medical components, a medical component being provided in each of the plurality of receptacles.

Abstract: A portable dual chamber auto-injector configured to store a dry opioid antagonist medicament separately from a liquid component, wherein a user actuated mixing system comprising a movable component to create a fluidic pathway between the first and second chambers and release a portion of energy from a pre-stored energy to drive a displacement mechanism into the first chamber and displace the liquid component into the second chamber and solubilize the opioid antagonist. A needle assembly in fluid communication with the second chamber can be used to transfer the solubilized opioid antagonist.

Abstract: A telescoping portable drug mixing and delivery device configured to store a dry medication separately from a liquid component, wherein a tensile force applied between the housing and a cap opens a valve and causes displacement of a fluid from a first chamber to a second chamber while simultaneously mixing the fluid with a dry medicament prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the reconstituted drug after the mixing stage is complete.

Abstract: A portable auto-injector configured to store a liquid component in a first chamber separately from a dry medication in a second chamber, wherein a first actuation mechanism opens a valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: A removable cap for use with an auto-injector device, whereupon removal of the cap triggers an actuating assembly that can cause an automatic mixing of medicament components in an auto-injector device and/or place the auto-injector in a state to be used.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap opens a rotary valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the reconstituted drug after the mixing stage is complete.

Abstract: A removable cap for use with an auto-injector device, whereupon removal of the cap triggers an actuating assembly that can cause an automatic mixing of medicament components in an auto-injector device and/or place the auto-injector in a state to be used.

Abstract: The present invention relates to a mixing and injector device which can include: a housing having a plurality of separate and distinct chambers disposed therein; one or more displacement mechanisms corresponding to each of the plurality of chambers disposed within the housing; a needle assembly being provided about one of the plurality of chambers, the needle assembly including the following: a septum; a needle being separated from the plurality of chambers by the septum, the needle having a proximal end configured to pierce the septum in an actuated state; and a needle carrier, the needle carrier being configured to translate axially with respect to and toward the septum and pierce the septum and provide fluid communication from the plurality of chambers through the needle in the actuated state.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: A portable auto-injector is capable of moving from a compact state where the auto-injector is in a shape easier to transport than in an activation state wherein the auto-injector has been extended. A safety limits movement of the needle assembly and prevents premature needle sticks. The drug is stored in one or more dry and wet medicament states until need.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap opens a rotary valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the reconstituted drug after the mixing stage is complete.

Abstract: A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a sliding valve and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

Abstract: The present invention relates to a mixing and injector device which can include: a housing having a plurality of separate and distinct chambers disposed therein; one or more displacement mechanisms corresponding to each of the plurality of chambers disposed within the housing; a needle assembly being provided about one of the plurality of chambers, the needle assembly including the following: a septum; a needle being separated from the plurality of chambers by the septum, the needle having a proximal end configured to pierce the septum in an actuated state; and a needle carrier, the needle carrier being configured to translate axially with respect to and toward the septum and pierce the septum and provide fluid communication from the plurality of chambers through the needle in the actuated state.