Abstract: Wire guides and methods of using an elongate wire guide with a first end portion and a flexible second end portion having an increased surface area is provided. The second end portion comprises a nominal outer circumference disposed about a longitudinal axis and having a first outer surface including the nominal outer circumference and defining a first surface area. Protuberances, indentations, peaks, and/or valleys are disposed substantially circumferentially about the nominal outer circumference and defining an effective perimeter greater than the nominal outer circumference and having a second outer surface defining a second surface area greater than the first surface area. Hydrophilic materials and therapeutic agents may be disposed partially on the second end portion and a coating, and a membrane may be disposed about second end portion and coating to form reservoirs or lumens for delivering hydrophilic materials and delivering therapeutic agents.

Abstract: Luer assemblies are provided having first and second connectors operatively coupled and securing tails of a proximal end section of a catheter disposed therebetween. A method for cutting a proximal end section of a catheter having distal and proximal ends is provided, a slit in the proximal end section exposing a catheter lumen and forming first and second tails having inner, outer, and peripheral engaging surfaces. Another method secures catheter tails disposed between operatively coupled first and second connectors, the first connector having a distal insert inserted into the exposed catheter lumen and a catheter engaging body about which the catheter tails are disposed, and the second connector having a catheter engaging body disposed about the catheter tails, wherein the connectors are configured to be operatively coupled to each other and to operatively couple the catheter tails disposed between the catheter engaging bodies of the first and second connectors.