Abstract: Pharmaceutical compositions of hepatotoxic compounds are provided in which the hepatotoxicity of the compounds is mitigated by including quantities of nicotinamide and methionine in the composition. Folic acid also can be included to further mitigate the hepatotoxic effects. The hepatotoxic compounds can include acetaminophen, methotrexate, atorvastatin, simvastatin, niacin, flucanozole, divalproex sodium, and valproic acid.

Abstract: Compositions and a methods are described for treating disorders of the small and large bowel, such as Crohn's disease, ulcerative colitis and irritable bowel syndrome, without producing any treatment-related systemic side effects and with minimal or no abdominal discomfort. A method of administration of civamide that is incorporated into soft gelatin capsules and administered with meals is described. Surprisingly, the method provides for diminishment of pain and inflammation of the small and large bowel without producing any systemic side effects or significant abdominal discomfort.

Abstract: A dermal method of treating chronic post-operative pain with a TRPV-1 receptor modulator. More specifically, a method for treating localized post-incisional neuropathic pain by administering a civamide-containing patch.

Abstract: An improved method of increasing tear production is by intranasally administering a therapeutically effective amount of a capsaicinoid compound to patients with deficient tear production. Optional incorporation into the intranasal formulation of a topical corticosteroid or topical anesthetic compound is used to reduce transient nasal stinging and burning which may sometimes accompany intranasal administration of capsaicinoids.

Abstract: A method of providing relatively long term diminishment or prevention of painful disorders comprises the topical or intranasal administration of civamide or one of its salts in an amount of about 0.001% to 1.0% by weight in a pharmaceutically acceptable vehicle over a relatively short term treatment period to provide unexpectedly long-lasting pain relief.

Abstract: A method of providing relatively long term diminishment or prevention of painful disorders comprises the topical or intranasal administration of civamide or one of its salts in an amount of about 0.001% to 1.0% by weight in a pharmaceutically acceptable vehicle over a relatively short term treatment period to provide unexpectedly long-lasting pain relief.

Abstract: A method of treating or preventing painful disorders comprises the intrathecal administration of civamide or one of its salts in an amount of about 0.001-1 mg by weight in a pharmaceutically acceptable vehicle to provide surprisingly long-lasting pain relief.

Abstract: A method for treating painful fibromuscular disorders comprising topical application to the skin of a therapeutically effective amount of a tricyclic antidepressant compound in a pharmaceutically acceptable vehicle.

Abstract: A method for preventing and treating headache pain comprising administering a tricyclic antidepressant compound locally to the nasal mucosa to a patient suffering from headaches.