Abstract: Prodrugs of proton pump inhibitors of Formulas 1 through 4, where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.
Type:
Grant
Filed:
July 15, 2003
Date of Patent:
May 24, 2005
Assignees:
Winston Pharmaceuticals, Inc., The United States of America as represented by the Department of Veteran Affairs, The Reagents of the University of California
Inventors:
Michael Garst, George Sachs, Jai M. Shin