Abstract: The present invention discloses ?-diketones, ?-diketones or ?-hydroxyketones or analogs thereof, that activate Wnt/?-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.
Type:
Application
Filed:
August 17, 2011
Publication date:
February 23, 2012
Applicant:
WINTHERIX, LLC
Inventors:
Sunil Kumar KC, David Mark Wallace, John Hood, Charlene F. Barroga
Abstract: Provided herein are methods for screening compounds for their ability to modulate the expression of certain isoforms of proteins that are associated with cancer, such as isoforms of proteins that participate in Wnt signaling in cancer cells.
Type:
Application
Filed:
May 7, 2009
Publication date:
November 19, 2009
Applicant:
WINTHERIX LLC
Inventors:
John Hood, Charlene F. Barroga, Dennis Carson, Desheng Lu