Patents Assigned to Wischem Co., Ltd.
  • Preparation method for (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid
    Patent number: 7371897
    Abstract: Provided is a novel preparation method of (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid represented by the following formula (1), a key intermediate of cilastatin used as a supplement to imipenem. The novel preparation method of the invention produces a pure (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid, a key intermediate of cilastatin, by selective hydrolysis of E isomers.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: May 13, 2008
    Assignee: Wischem Co., Ltd.
    Inventors: Yang Rai Cho, Young Ji Shim, Eon Cheol Koo, Seon Yi Jeong, Byung Hwan Kim