Patents Assigned to Wisconsin Alumni Research Foundation
  • Patent number: 11371003
    Abstract: Photoreceptor scaffolds and scaffold systems including the photoreceptor scaffolds are described herein. The scaffolds and scaffold systems can be used for transplantation of organized photoreceptor tissue, with or without RPE, which may improve grafted cell survival, integration, and functional visual rescue. Particularly, the photoreceptor scaffold is structured from a biocompatible film, patterned with an array of unique through-holes having a curvilinear cell receiver and at least one cell guide channel.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: June 28, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Zhenqiang Ma, Yei Hwan Jung, Michael Phillips, David Gamm, Shaoqin Gong
  • Patent number: 11371023
    Abstract: The present invention relates to artificial transcription factors (ATFs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell fates. In particular, provided herein is a zinc-finger based ATF library that can be screened in cells by looking for expression of a specific gene (e.g., reporter expression), monitoring for cell surface markers or morphology, or via functional assays.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: June 28, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Asuka Eguchi, Aseem Z. Ansari
  • Patent number: 11362600
    Abstract: A generator/controller for electrostatic motors exploits properties of a delta-connected electrostatic motor to accommodate high common mode DC offset voltages thus permitting construction of an electrostatic drive circuit outputting unipolar sinusoidal power and having a substantial reduction in the complexity and size.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: June 14, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peter Killeen, Daniel Colin Ludois
  • Patent number: 11358996
    Abstract: Described herein are FGF-23 epitope peptides, methods of producing antibodies in laying hens by injecting the peptides, and methods of improving resistance to eggshell breakage and/or increasing eggshell strength by administering an FGF-23 epitope peptide to a laying hen.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: June 14, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Daniel Butz, Zhouzheng Ren, Alexis Jo Piepenburg, Mark Eric Cook
  • Patent number: 11357950
    Abstract: The present disclosure pertains to delivering sensory stimulation to a user during a sleep session. In some embodiments, sensors are configured to generate output signals conveying information related to brain activity of the user during the sleep session. Sensory stimulators are configured to provide the sensory stimulation to the user during the sleep session. One or more processors are configured to determine a demographic group for the user; select a stimulation parameter model associated with the demographic group of the user from a set of stimulation parameter models associated with different demographic groups; and control the one or more sensory stimulators to deliver the sensory stimulation to the user based on the stimulation parameter model for the demographic group of the user and the output signals.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: June 14, 2022
    Assignees: KONINKLIJKE PHILIPS N.V., WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Gary Nelson Garcia Molina, Tsvetomira Kirova Tsoneva, Brady Alexander Riedner, Giulio Tononi
  • Publication number: 20220178033
    Abstract: A method of making alkenes and/or epoxides from alkanes and hydroxy-alkanes, respectively. In a reactor having an anode and a cathode separated by an ion exchange membrane, and containing a solution comprising water, halogen ions, and an alkane and/or a hydroxy-alkane, apply a potential across the anode and the cathode such that a halogenated intermediate is produced at the anode as an anolyte and hydroxyl ions are produced at the cathode as a catholyte; and combining the anolyte and the catholyte to yield an alkene and/or an epoxide.
    Type: Application
    Filed: December 8, 2021
    Publication date: June 9, 2022
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Marcel Schreier, Christine E. Lucky
  • Publication number: 20220177489
    Abstract: Synthetic transcriptions factors for modulation of frataxin expression and methods of use are described herein.
    Type: Application
    Filed: October 22, 2019
    Publication date: June 9, 2022
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Aseem Z. Ansari, Ashraf Mohammed
  • Publication number: 20220177494
    Abstract: Provided herein are silica metal organic framework (SMOF) nanoparticles that are pH-responsive for delivery of bioactive molecules.
    Type: Application
    Filed: April 8, 2020
    Publication date: June 9, 2022
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Shaoqin GONG, Yuyuan WANG
  • Patent number: 11350895
    Abstract: A system and method for material decomposition of a single energy spectrum x-ray dataset includes accessing the single energy spectrum x-ray dataset, receiving a user-selection of a desired energy for decomposition, and decomposing the single energy spectrum x-ray dataset into material bases as a linear combination of energy dependence function of selected basis materials and the corresponding spatial dependence material bases images.
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: June 7, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Guang-Hong Chen, Yinsheng Li
  • Patent number: 11351263
    Abstract: Provided herein are nanoplexes comprising a payload selected from a protein and/or a polynucleic acid; and a plurality of copolymers comprising a first copolymer that is poly(N,N?-bis(acryloyl)cystamine-poly(aminoalkyl)) (PBAP), a second copolymer that is poly(C2-3 akylene glycol)-PBAP-poly(C2-3 akylene glycol), and a third copolymer that is TG-poly(C2-3 akylene glycol)-PBAP-poly(C2-3 akylene glycol)-TG wherein TG at each occurrence is independently a targeting ligand, a cell penetrating peptide, an imaging agent or a capping group, provided that a plurality of TG groups is a targeting ligand; wherein the payload is non-covalently complexed to one or more of the copolymers, one or more of the first, second, and/or third copolymers comprises an endosomal escape group having a pKa of about 4.5 to about 6.5, and optionally one or more of the first, second, and/or third copolymers comprises a host and a guest non-covalent crosslinker.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: June 7, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Shaoqin Gong, Yuyuan Wang, Krishanu Saha, Amr Ashraf Abdeen
  • Patent number: 11352604
    Abstract: An improvement to the GiWi protocol for differentiating human pluripotent cells to developmentally mature cardiomyocytes includes a step of activating innate immunity in mesoderm stage cells in the in vitro differentiation culture. When the mesoderm cells, which are precursors to cardiac progenitor cells, are primed by exposure to an activator of innate immunity, a population of cardiomyocytes is generated that is more developmentally mature than is generated in the GiWi protocol without the primed step. Also provided herein are in vitro ventricular conductive microtissues and isolated, in vitro populations of ventricular conduction system-like cells and methods for making the same.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: June 7, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Mitch James Biermann, Timothy Joseph Kamp
  • Patent number: 11344719
    Abstract: A wearable medical bandage is provided having an energy harvesting generator that harvests mechanical energy from the user's natural body and muscle motions to produce electrical energy. The electrical energy induces an electric potential across the wound opening producing accelerated skin wound recovery under the voltage fluctuations produced by the power generator.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 31, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xudong Wang, Yin Long, Weibo Cai, Hao Wei
  • Patent number: 11345895
    Abstract: The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification and enhanced T cell potential. In one embodiment, the method uses ETS transgene induction at the mesodermal stage of differentiation. In another embodiment, the method activates ERK and NOTCH signaling at the mesodermal stage of differentiation.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: May 31, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Igor I. Slukvin, Mi Ae Park, Akhilesh Kumar
  • Patent number: 11344627
    Abstract: Described herein are hybrid nanoparticles that are exosomes loaded with one or more nanoparticle dendrimers. Also included are pharmaceutical compositions including the hybrid nanoparticles and methods of making the hybrid nanoparticles. Also described is a method of treating a human subject by administering to the human subject the above-described hybrid nanoparticles.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: May 31, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Seungpyo Hong, Sin-Jung Park
  • Patent number: 11339267
    Abstract: Green, fast and easy evaporating organic solvent for use as a lubricant in the processing of polytetrafluoroethylene (PTFE) and expanded polytetrafluoroethylene (ePTFE) products and processes of using the solvents to fabricate the products are disclosed herein. The products can be used in the field of bio- and medical applications, such as for use in vascular grafts, cardiovascular and soft tissue patches, facial implants, surgical sutures, and endovascular prosthesis, and for any products known in the aerospace, electronics, fabrics, filtration, industrial and sealant arts.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: May 24, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Lih-Sheng Turng, Yiyang Xu, Yu-Jyun Lin, Dong-Fang Wang
  • Patent number: 11341943
    Abstract: A musical instrument support system provides support to a musician's elbow when the musician's arm is in a raised position, thus alleviating fatigue and strain on the musician's shoulder, neck, back and arms. The support system includes a harness worn on the musician's torso, a rib plate supported by the harness that is worn along the musician's torso, an elbow support that receives the musician's elbow, and a swivel joint that joins the elbow support to the rib plate and permits the elbow plate to rotate and angulate about a vertical axis and move laterally from the rib plate in all directions within a horizontal plane.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: May 24, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Adrianna N. Carrion Vaughn, Jonah Mudge
  • Patent number: 11335781
    Abstract: Heterostructures that include a bilayer composed of epitaxial layers of vanadium dioxide having different rutile-to-monoclinic phase transition temperatures are provided. Also provided are electrical switches that incorporate the heterostructures. The bilayers are characterized in that they undergo a single-step, collective, metal-insulator transition at an electronic transition temperature. At temperatures below the electronic transition temperature, the layer of vanadium dioxide having the higher rutile-to-monoclinic phase transition temperature has an insulating monoclinic crystalline phase, which is converted to a metallic monoclinic crystalline phase at temperatures above the electronic transition temperature.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: May 17, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Chang-Beom Eom, Daesu Lee
  • Patent number: 11333669
    Abstract: The invention provides mass spectrometry methods, compositions and systems which enable a unique platform for analyte quantitation accessing very high degrees of multiplexing and accurate quantification, particularly well-suited for a range of quantitative analysis for proteomics applications. Embodiments of the present methods and systems combine isotopic coding agents characterized by very small differences in molecular mass with mass spectrometry methods providing large resolving power to provide relative or absolute analyte quantification in a large number of samples.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: May 17, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Joshua J. Coon, Alex Hebert
  • Patent number: 11326178
    Abstract: The invention relates to nucleic acids encoding a p-coumaroyl-CoA:monolignol transferase and to inhibitory nucleic acids adapted to inhibit the expression and/or translation of a p-coumaroyl-CoA:monolignol transferase RNA. Inhibition of p-coumaroyl-CoA:monolignol transferase in plants improves the incorporation of monolignol ferulates into the lignin of plants, giving rise to plant biomass that is more easily processed into useful products such as paper and biofuels.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: May 10, 2022
    Assignees: Wisconsin Alumni Research Foundation, Board of Trustees of Michigan State University, The Board of Trustees of Illinois State University
    Inventors: Curtis Wilkerson, John Ralph, Saunia Withers, John Sedbrook
  • Patent number: 11326174
    Abstract: The present invention relates to materials and methods for the production of ethanol. More particularly, the present invention provides genetically modified strains of Saccharomyces cerevisiae exhibiting decreased level of BCY1 protein activity and capable of anaerobic fermentation of xylose into ethanol without the need for cell growth. Also provided are methods of using such genetically engineered yeast strains for improved anaerobic xylose fermentation in the yeast for industrial-scale production of various fuels, chemical feedstocks, and synthetic polymers.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: May 10, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kevin S Myers, Audrey P Gasch