Patents Assigned to Wisconsin Alumni Research Foundation
  • Patent number: 9822216
    Abstract: Provided herein are microphase-separated materials including a plurality of block copolymers tethered together at their A-B junction points. The tethered-together block copolymers, referred to as a block copolymer bottlebrush, provide microphase-separated materials having smaller domain spacing than previously achievable using block copolymer systems.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: November 21, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Mahesh Kalyana Mahanthappa, Frank W. Speetjens
  • Patent number: 9824890
    Abstract: A reactor for growing or depositing semiconductor films or devices. The reactor may be designed for inline production of III-V materials grown by hydride vapor phase epitaxy (HVPE). The operating principles of the HVPE reactor can be used to provide a completely or partially inline reactor for many different materials. An exemplary design of the reactor is shown in the attached drawings. In some instances, all or many of the pieces of the reactor formed of quartz, such as welded quartz tubing, while other reactors are made from metal with appropriate corrosion resistant coatings such as quartz or other materials, e.g., corrosion resistant material, or stainless steel tubing or pipes may be used with a corrosion resistant material useful with HVPE-type reactants and gases. Using HVPE in the reactor allows use of lower-cost precursors at higher deposition rates such as in the range of 1 to 5 ?m/minute.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: November 21, 2017
    Assignees: Alliance for Sustainable Energy, LLC, Wisconsin Alumni Research Foundation
    Inventors: David L. Young, Aaron Joseph Ptak, Thomas F. Kuech, Kevin Schulte, John D. Simon
  • Patent number: 9821028
    Abstract: Disclosed herein are methods of controlling parasitic worms in herbivorous mammals and other species by orally administering an isolated antibody that specifically binds the interleukin-10 peptide or an interleukin-10 peptide. In the case of herbivorous mammals such as cattle, for example, administration of the anti-IL-10 antibodies increases weight gain and increases feed efficiency in the animals.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: November 21, 2017
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Mark Eric Cook, Daniel Meilahn Schaefer, Mitchell Raymond Schaefer, Jordan Marshall Sand, Larry Smith
  • Patent number: 9821029
    Abstract: Described herein are methods of reducing Salmonella in the intestines of poultry in need thereof by administering to a poultry bird an effective amount of an interleukin-10 peptide or an isolated antibody that specifically binds an interleukin-10 peptide. Administering may be performed within 1 to 4 weeks of harvest of the poultry in order to reduce Salmonella transmission to human consumers. Also included herein are finishing feeds that include an interleukin-10 peptide or an isolated antibody that specifically binds an interleukin-10 peptide.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: November 21, 2017
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
    Inventors: Mark Eric Cook, Jordan Marshall Sand, Mike H. Kogut, Christina L. Swaggerty
  • Patent number: 9814736
    Abstract: Disclosed are methods of administering 2-methylene-19-nor-(20S)-1?,25-dihydroxyvitamin D3 to treat and/or prevent secondary hyperparathyroidism and/or its accompanying symptoms in a subject having or at risk for developing secondary hyperparathyroidism, including a subject previously administered a calcimimetic.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: November 14, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Lori A. Plum, Margaret Clagett-Dame
  • Patent number: 9814770
    Abstract: The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: November 14, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Christopher W. Olsen, Gabriele A. Landolt, Alexander I. Karasin
  • Patent number: 9809844
    Abstract: Methods are provided for tagging, characterizing and sorting double-stranded biomolecules while maintaining the integrity of the biomolecules.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: November 7, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David C. Schwartz, Kyubong Jo, Dalia M. Dhingra
  • Patent number: 9809627
    Abstract: The present disclosure describes cyclized peptides that inhibit A? toxicity and therefore can be used as therapeutic agents to treat Alzheimer's Disease.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: November 7, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Regina M. Murphy, Patricia Y. Cho, Jeffrey A. Johnson, Xiaomeng Lu
  • Patent number: 9809586
    Abstract: Biheteroaryl dicarboxylates and esters, and salts thereof which are useful as modulators of CP4H activity and more particularly as inhibitors of CP4H. Compounds of formula: and salts thereof where: X is S, O, NH, or NR, where R is an alkyl group having 1-3 carbon atoms; R1 and R2 independently are —OR7, or —NHSO2R8, where R7 is selected from: hydrogen, alkyl, alkenyl, alkoxyalkyl, —R?—CO—R?, —R?—CO—O—R?, —CO—R?, —R?—O—CO—R?, —R?—CO—NR?, —CO—NR?, or —R?—O—CO—NR?, and R8 is selected from hydrogen, alkyl, aryl, arylalkyl; R3, R4 and R6 independently are hydrogen, alkyl, alkoxy, alkenyl, alkenoxy, haloalkyl, haloalkenyl, halogen, hydroxyl, hydroxyalkyl, hydroxyalkenyl, aryl, aryloxy, arylalkyl or arylalkyloxy; R5 is hydrogen, halogen, alkyl having 1-3 carbon atoms, or alkoxy having 1-3 carbon atoms; —R?— is a divalent straight chain or branched alkylene, and —R? is an alkyl, alkenyl, arylalkyl, or aryl group. Methods for inhibition of CP4H in vivo and in vitro.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: November 7, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, James Vasta
  • Patent number: 9812727
    Abstract: Disclosed are systems for the electrocatalytic reduction of oxygen, having redox mediator/redox catalyst pairs and an electrolyte solution in contact with an electrode. The redox mediator is included in the electrolyte solution, and the redox catalyst may be included in the electrolyte solution, or alternatively, may be in contact with the electrolyte solution. In one form a cobalt redox catalyst is used with a quinone redox mediator. In another form a nitrogen oxide redox catalyst is used with a nitroxyl type redox mediator. The systems can be used in electrochemical cells wherein neither the anode nor the cathode comprise an expensive metal such as platinum.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: November 7, 2017
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Shannon S. Stahl, James B. Gerken, Colin W. Anson
  • Patent number: 9803292
    Abstract: Methods for growing microstructured and nanostructured graphene by growing the microstructured and nanostructured graphene from the bottom-up directly in the desired pattern are provided. The graphene structures can be grown via chemical vapor deposition (CVD) on substrates that are partially covered by a patterned graphene growth barrier which guides the growth of the graphene.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: October 31, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael S. Arnold, Padma Gopalan, Nathaniel S. Safron, Myungwoong Kim
  • Patent number: 9796694
    Abstract: The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: October 24, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Helen E. Blackwell, Grant D. Geske, Jennifer C. Campbell Butler
  • Patent number: 9796660
    Abstract: The invention provides compounds and methods, for example, to carry out organocatalytic Michael additions of aldehydes to cyclically constrained nitroethylene compounds catalyzed by a proline derivative to provide cyclically constrained ?-substituted-?-nitro-aldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96 to >99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to cyclically constrained protected ?-amino acid residues, which are essential for systematic conformational studies of ?-peptide foldamers. New methods are also provided to prepare other ?-amino acids and peptides. These new building blocks can be used to prepare foldamers, such as ?/?-peptide foldamers, that adopt specific helical conformations in solution and in the solid state.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: October 24, 2017
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Samuel Helmer Gellman, Li Guo, Michael Giuliano
  • Patent number: 9790553
    Abstract: Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: October 17, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Dohun Pyeon, Paul F. Lambert, Michael A. Newton, Paul G. Ahlquist
  • Patent number: 9790483
    Abstract: Methods and reagents for esterification of biological molecules including proteins, polypeptides and peptides. Diazo compounds of formula I: where R is hydrogen, an alkyl, an alkenyl or an alkynyl, RA represents 1-5 substituents on the indicated phenyl ring and RM is an organic group, which includes a label, a cell penetrating group, a cell targeting group, or a reactive group or latent reactive group for reaction to bond to a label, a cell penetrating group, or a cell targeting group, among other organic groups are useful for esterification of biological molecules. Also provided are diazo compounds which are bifunctional and trifunctional coupling reagents as well as reagents for the synthesis of compounds of formula I.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: October 17, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Kalie Mix
  • Patent number: 9786853
    Abstract: High density films of semiconducting single-walled carbon nanotubes having a high degree of nanotube alignment are provided. Also provided are methods of making the films and field effect transistors (FETs) that incorporate the films as conducting channel materials. The single-walled carbon nanotubes are deposited from a thin layer of organic solvent containing solubilized single-walled carbon nanotubes that is spread over the surface of an aqueous medium, inducing evaporative self-assembly upon contacting a solid substrate.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: October 10, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael Scott Arnold, Padma Gopalan, Gerald Joseph Brady, Yongho Joo, Harold T. Evensen
  • Patent number: 9782118
    Abstract: Parameters extracted from high definition manometric measurements of the pharynx and upper esophagus at preidentified locations and times are applied to a supervised learning machine trained using x-ray fluoroscopy data to provide diagnostic information comparable to that of x-ray fluoroscopy without radiation exposure.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: October 10, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Matthew Richard Hoffman, Jack J Jiang, Zhixian Geng, Timothy Michael McCulloch
  • Publication number: 20170281643
    Abstract: The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Application
    Filed: March 29, 2017
    Publication date: October 5, 2017
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Aseem Ansari, Graham Erwin, Matthew Grieshop
  • Publication number: 20170285042
    Abstract: Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.
    Type: Application
    Filed: June 1, 2017
    Publication date: October 5, 2017
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Joshua J. COON, Michael S. WESTPHALL
  • Patent number: 9777998
    Abstract: A device is provided for camouflaging an object from an infrared detection apparatus. The device includes a cloak positionable between the object and the infrared detection apparatus. The cloak includes a layer of infrared absorptive material including a plurality of silicon nanowires. A flexible substrate has a first surface operatively connected to an inner surface of the layer. The substrate includes a heat dissipation arrangement for dissipating heat generated by the cloak during operation. An array of infrared emitters is operatively connected to a second surface of the substrate. The array of infrared emitters selectively radiates an infrared pattern to disguise the object to the infrared detection apparatus.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: October 3, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hongrui Jiang, Seyyed Mohammad Javad Moghimi, Guangyun Lin