Patents Assigned to Wisconsin Alumni Research Foundation
  • Publication number: 20180298353
    Abstract: The invention is directed to p-coumaroyl-CoA:monolignol transferase enzymes, nucleic acids encoding p-coumaroyl-CoA:monolignol transferase enzymes, and inhibitory nucleic acids adapted to inhibit the expression and/or translation of p-coumaroyl-CoA:monolignol transferase RNA; expression cassettes, plant cells, and plants that have or encode such nucleic acids and enzymes; and methods of making and using such nucleic acids, enzymes, expression cassettes, cells, and plants.
    Type: Application
    Filed: April 18, 2018
    Publication date: October 18, 2018
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: John Ralph, Steven D. Karlen, Rebecca Anne Smith, Brian Fox, Emily Beebe, Craig Bingman
  • Patent number: 10098332
    Abstract: Described herein are methods and compositions for modulating bovine birth rate by following a breeding scheme based on the presence of the trio haplotype, which is strongly linked to the propensity to give birth to multiple calves in one event.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: October 16, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Brian Wayne Kirkpatrick
  • Patent number: 10102671
    Abstract: Systems and methods for generating approximations and other representations of data in a data set include a generalized non-uniform rational B-splines (NURBS) framework that facilitates optimized computer-generated representations having high accuracy and requiring less computing resources than previous frameworks capable of achieving similar accuracy. The framework includes a set of rational basis functions that define a mesh parametrization of the data set; these rational basis functions are based on the typical NURBS rational basis functions, but decoupled to provide discrete weights in each direction of a parametrized space. The value of each decoupled weight can be individually altered to improve the accuracy of the representation in the corresponding direction without altering the underlying mesh parametrization. The accuracy and efficiency of the proposed methods, particularly for data sets including discontinuities or localized gradients, is demonstrated through numerical experiments.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: October 16, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Krishnan Suresh, Alireza H. Taheri
  • Patent number: 10100163
    Abstract: The present invention provides crosslinked epoxy-functional copolymer films and microarrays built from the crosslinked epoxy-functional copolymer films. Microarrays incorporating the copolymers include a substrate on which a film of the crosslinked epoxy-functional copolymer is disposed and target molecules bound to the copolymer film. The crosslinked polymer films are well-suited for use as scaffolds for target molecules in microarrays because they provide a high density of binding sites for the target molecules, are mechanically stable, and may be coated onto a wide range of substrates.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: October 16, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Padma Gopalan
  • Publication number: 20180289026
    Abstract: Disclosed are processes for removing lactose from dried milk products to produce dried protein fortified and/or mineral fortified milk products having a reduced lactose content with minimal use, or even without the use, of membrane ultrafiltration, diafiltration, or additional drying equipment. Additionally, a high lactose-containing stream product is also produced. The dried protein fortified milk products are physically and chemically similar to dried milk protein concentrates and can be used for protein fortifiers in various food applications.
    Type: Application
    Filed: June 13, 2018
    Publication date: October 11, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Franco Milani, Byron Toledo Davalos
  • Patent number: 10094820
    Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: October 9, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Berwin Berthier, Peter Cavnar, John Guckenberger, David Beebe
  • Publication number: 20180286649
    Abstract: A new approach is described herein for outfitting a mass spectrometer with an infrared laser that provides an improved method of ion dissociation. One embodiment, generally referred to as Activated Ion Electron Transfer Dissociation (AI-ETD) utilizes additional energy from photons during fragmentation to generate extensive fragmentation by interacting with peptides or proteins that are not fully fragmented or separated in the high pressure linear ion trap, thus allowing for increased information during MS/MS. Additionally, a new activation scheme generally referred to as AI-ETD+ is also described that combines AI-ETD in the high pressure cell of the linear ion trap with additional infrared multi-photon dissociation (IRMPD) activation in the low pressure cell. These methods provide improved fragmentation and sequence coverage without introducing additional time to the scan duty cycle.
    Type: Application
    Filed: March 26, 2018
    Publication date: October 4, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Joshua COON, Nicholas RILEY, Michael WESTPHALL
  • Patent number: 10088238
    Abstract: Disclosed are methods and apparatuses for cooling a work piece surface using two-phase impingement, such as direct jet impingement. Preferred method include flowing a coolant through a chamber comprising a surface to be cooled by projecting a jet stream of coolant against the surface while maintaining pressure in the chamber to permit at least a portion of coolant contacting the surface to boil. Preferred apparatuses include a chamber comprising the surface and tubular nozzles configured to project a stream of coolant against the surface, a pump for forcing coolant through the tubular nozzles, a pressurizer for maintaining an appropriate pressure in the chamber, and a heat exchanger for cooling the coolant exiting the chamber. The apparatuses may further include a pressure regulator for detecting changes in temperature of the coolant exiting the chamber and communicating with the pressurizer to adjust the maintained pressure accordingly.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: October 2, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Timothy A. Shedd
  • Patent number: 10089240
    Abstract: A computer architecture provides a memory cache that is accessed not by physical addresses but by virtual addresses directly from running processes. Ambiguities that can result from multiple virtual addresses mapping to a single physical address are handled by dynamically tracking synonyms and connecting a limited number of virtual synonyms mapping to the same physical address to a single key virtual address that is used exclusively for cache access.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: October 2, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Gurindar S. Sohi, Hongil Yoon
  • Patent number: 10090150
    Abstract: A method of forming a low dielectric constant (low-k) dielectric is disclosed. The method includes providing a substrate and forming a dielectric including porogens over the substrate. While subjecting the dielectric to a first pressure, the dielectric is exposed to ultraviolet (UV) radiation. The dielectric is also subject to a second pressure less than 1×10?3 Torr. While subjecting the dielectric to the second pressure, the dielectric is exposed to vacuum UV (VUV) radiation having one or more photon energies greater than 7 eV. Since it is difficult for VUV radiation to travel through a medium at a pressure greater than 10 Torr without being absorbed by intermittent materials, subjecting the dielectric to the second pressure creates a medium wherein the dielectric can be exposed to the VUV radiation. By exposing the dielectric to UV and VUV radiation, the dielectric can achieve a reduced dielectric constant and increased mechanical properties.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: October 2, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: J. Leon Shohet, Huifeng Zheng, Xiangyu Guo, Weiyi Li, Joshua Blatz, Dongfei Pei
  • Patent number: 10090603
    Abstract: A lens is provided. The lens includes a first two-dimensional (2-D) grid of capacitive patches and a first sheet layer. The first sheet layer includes a dielectric sheet and a second 2-D grid of capacitive patches. The dielectric sheet has a front surface and a back surface. The first 2-D grid of capacitive patches is mounted directly on the back surface of the dielectric sheet, and the second 2-D grid of capacitive patches is mounted directly on the front surface of the dielectric sheet. The first 2-D grid of capacitive patches is aligned with the second 2-D grid of capacitive patches to form a time delay circuit at each grid position of the aligned 2-D grids.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: October 2, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Nader Behdad, Meng Li
  • Patent number: 10080777
    Abstract: The invention provides for peptides from syndecan 4 and methods of use therefor. These peptides can inhibit ?6?4 integrin interaction with EGFR, thereby preventing tumor cell growth and tissue invasion, or inhibiting scarring and/or pathologic neovascularization.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Alan Rapraeger
  • Patent number: 10082506
    Abstract: The present disclosure provides for methods of diagnosing and treating bacterial infections. Human Intelectin 1 (hIntL-1) has been shown to bind selectively to glycan components on bacteria including Streptococcus pneumonia, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumonia and Yersinia pestis. This interaction can be targeted to identify, purify and therapeutically target such organisms.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: September 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Laura L. Kiessling, Darryl A. Wesener, Kittikhun Wangkanont
  • Patent number: 10081792
    Abstract: The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem cells. In particular, provided herein are highly efficient and reproducible methods of obtaining human primitive macrophages and microglia from human pluripotent stem cells, where the primitive macrophages and microglia can be suitable for clinically relevant therapeutic applications.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: September 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James A. Thomson, Nicholas E. Propson, Michael P. Schwartz, Zhonggang Hou, Gene I. Uenishi, Igor I. Slukvin, William L. Murphy, Jue Zhang
  • Publication number: 20180265880
    Abstract: The invention generally relates to arogenate dehydrogenase polynucleotides and methods of using the same. More specifically, the invention relates in part to compositions including arogenate dehydrogenase polynucleotides from beet varieties and other Caryophyllales species and methods of using the same.
    Type: Application
    Filed: February 16, 2018
    Publication date: September 20, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Hiroshi A. Maeda, Marcos Viana de Oliveira
  • Patent number: 10077224
    Abstract: A method of making 1,5-pentanediol from tetrahydrofurfural alcohol. The method includes the steps of dehydrating tetrahydrofurfural alcohol (THFA) to dihydropyran (DHP); hydrating at least a portion of the DHP to 2-hydroxy-tetrahydropyran (2-HY-THP) in the presence of a solid acid catalyst; and hydrogenating at least a portion of the 2-HY-THP to 1,5-pentanediol. The method can be conducted entirely in the absence of noble metal catalysts.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: September 18, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: George Willis Huber, James A. Dumesic, Kevin J. Barnett
  • Patent number: 10077448
    Abstract: The present invention discloses methods and systems for producing fungal secondary metabolites. The invention also discloses genetically modified organisms and kits including such organisms for producing fungal secondary metabolites.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: September 18, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nancy Keller, Philipp Wiemann
  • Patent number: 10077507
    Abstract: A method for growing single-crystal perovskite structures comprises immersing a film of a metal precursor compound on a surface of a substrate, the metal precursor compound comprising a metal ion B, in a solution comprising a cation precursor compound, the cation precursor compound comprising a cation ion A and an anion X, at a concentration of the cation precursor compound, a growth time, and a growth temperature sufficient to dissolve the film to release the metal ion B to form a complex with the anion X and sufficient to induce recrystallization of the complex with the cation ion A to form a plurality of single-crystal perovskite structures composed of A, B and X. The single-crystal perovskite structures, devices incorporating the same, and methods of using the devices are also provided.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: September 18, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Song Jin, Yongping Fu, Fei Meng
  • Publication number: 20180256251
    Abstract: A balun includes a center conductor, a dielectric material, a tapered wall, a ring, and a prong. The center conductor extends a length of the balun. The dielectric material surrounds the center conductor along the length of the balun. The tapered wall forms a portion of a tube between a first wall and a second wall. The first wall is opposite the second wall. The tapered wall is formed of a conductive material. The portion of the tube forms a slot exposing the dielectric material. The ring connects to the second wall of the tapered wall and is formed of the conductive material. The ring forms a tube surrounding the center conductor and the dielectric material. The prong connects to the ring to extend toward the first wall and is formed of the conductive material. The prong extends over a portion of the dielectric material exposed by the slot.
    Type: Application
    Filed: March 9, 2017
    Publication date: September 13, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Susan C. Hagness, Nader Behdad, Hung Thanh Luyen
  • Publication number: 20180261922
    Abstract: An antenna system is provided that includes a coaxial cable, an antenna, a reflector wall, and a slot wall. The reflector wall is formed of a conductive material connected to a conductive shield to extend in an axial direction, is separated from an antenna conductor by a second dielectric material in a radial direction relative to the antenna conductor, and partially surrounds the antenna conductor in the radial direction from a first angle to a second angle when projected into a radial plane. The slot wall is formed through a portion of the conductive shield to expose a dielectric material from a third angle to a fourth angle when projected into the radial plane, is formed on a first side relative to a base. The first angle, the second angle, the third angle, and the fourth angle are defined relative to a common axis parallel to the radial plane.
    Type: Application
    Filed: March 9, 2017
    Publication date: September 13, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Nader Behdad, Susan C. Hagness, Yahya Mohtashami