Patents Assigned to Wisconsin Alumni Research Foundation
  • Patent number: 9889101
    Abstract: A method for treatment of cervical or vaginal cancer and their associated dysplasia, including the steps of identifying a human cervical or vaginal cancer and/or dysplasia patient, administering an effective amount of an estrogen antagonist therapy to the patient, wherein the amount is effective to reduce cancer and dysplasia symptoms, and observing a reduction of cancer and dysplasia symptoms in the patient.
    Type: Grant
    Filed: March 12, 2012
    Date of Patent: February 13, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Paul F. Lambert, SangHyuk Chung
  • Patent number: 9890363
    Abstract: The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: February 13, 2018
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Yoshihiro Kawaoka, Gabriele Neumann, Jihui Ping
  • Patent number: 9889317
    Abstract: Systems and methods for generating a radiation treatment plan using inverse planning objectives that are automatically determined based on patient data and the physical capabilities of the radiation treatment system are provided. In particular, the planned target volumes and organ-at-risk (OAR) volumes are used to automatically partition the OAR volumes into one or more avoidance volumes, for which particular inverse planning objectives are established based on the physical capabilities of the treatment system. As an example, an inverse planning objective may include establishing a particular dose gradient over one or more avoidance volumes. Because such inverse planning objectives are based on conditions and constraints of the treatment system physics, rather than a desired percentage of the prescribed dose, they may be referred to as “physical objectives.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: February 13, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Edward T. Bender, Jacob Hoberg
  • Patent number: 9885119
    Abstract: Electrochemical cells and photoelectrochemical cells for the reduction of furfurals are provided. Also provided are methods of using the cells to carry out the reduction reactions. Using the cells and methods, furfurals can be converted into furan alcohols or linear ketones.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: February 6, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kyoung-Shin Choi, John James Roylance, Stephen R. Kubota
  • Patent number: 9879270
    Abstract: Provided herein are constructs for genome editing or genetic engineering in fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a polynucleotide encoding a thymidine kinase operably connected to a promoter, suitably a constitutive promoter; a polynucleotide encoding an endonuclease operably connected to an inducible promoter; and a recognition site for the endonuclease. The constructs may also include selectable markers for use in selecting recombinations.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: January 30, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Christopher Todd Hittinger, William Gerald Alexander
  • Patent number: 9879271
    Abstract: Compositions and methods for the expression of one or more coding sequences are provided which use an internal ribosome entry site (IRES) from Triticum mosaic virus (TriMV) to facilitate translation and expression of a polypeptide from an mRNA strand.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: January 30, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Aurelie Mamisoa Rakotondrafara, Jincan Zhang
  • Patent number: 9878007
    Abstract: Peptides derived from amino acid residues 210 to 240 of human syndecan 1 and methods of use of such peptides are described. These peptides can inhibit activation of ?4?1 integrin (also known as very late antigen-4, VLA-4), and can inhibit engagement of VLA-4 with vascular endothelial growth factor receptor-2 (VEGFR2), thereby preventing tumor cell growth and tissue invasion.
    Type: Grant
    Filed: February 15, 2016
    Date of Patent: January 30, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Alan Rapraeger, Oisun Jung
  • Publication number: 20180025794
    Abstract: A method is described herein for coating the substrate of a component for use in a water cooled nuclear reactor to provide a barrier against corrosion. The method includes providing a zirconium alloy substrate; and coating the substrate with particles selected from the group consisting of metal oxides, metal nitrides, FeCrAl, FeCrAlY, and high entropy alloys. Depending on the metal alloy chosen for the coating material, a cold spray or a plasma arc spray process may be employed for depositing various particles onto the substrate. An interlayer of a different material, such as a Mo, Nb, Ta, or W transition metal or a high entropy alloy, may be positioned in between the Zr-alloy substrate and corrosion barrier layer.
    Type: Application
    Filed: October 3, 2016
    Publication date: January 25, 2018
    Applicants: WESTINGHOUSE ELECTRIC COMPANY LLC, WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: EDWARD J. LAHODA, PENG XU, ZESES KAROUTAS, SIMON MIDDLEBURGH, SUMIT RAY, KUMAR SRIDHARAN, BENJAMIN MAIER, GREG JOHNSON
  • Publication number: 20180025793
    Abstract: A method is provided for coating the substrate of a component, such as a zirconium alloy cladding tube, for use in a water cooled nuclear reactor under normal operating conditions and under high temperature oxidation conditions. The method includes heating a pressurized carrier gas to a temperature between 200° C. and 1200° C., adding chromium or chromium-based alloy particles having an average diameter of 20 microns or less to the heated carrier gas, and spraying the carrier gas and particles onto the substrate at a velocity, preferably from 800 to 4000 ft./sec. (about 243.84 to 1219.20 meters/sec.), to form a chromium and/or chromium-based alloy coating on the substrate to a desired thickness.
    Type: Application
    Filed: October 3, 2016
    Publication date: January 25, 2018
    Applicants: WESTINGHOUSE ELECTRIC COMPANY LLC, WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: EDWARD J. LAHODA, PENG XU, ZESES KAROUTAS, SUMIT RAY, KUMAR SRIDHARAN, BENJAMIN MAIER, GREG JOHNSON
  • Patent number: 9873900
    Abstract: The present invention is directed to methods and materials for RNA-mediated gene assembly from oligonucleotide sequences. In some embodiments, the oligonucleotides used for gene assembly are provided in an array format. An RNA polymerase promoter is appended to surface-bound oligonucleotides and a plurality of RNA copies of each oligonucleotide are then produced with an RNA polymerase. These RNA molecules self-assemble into a desired full-length RNA transcript by hybridization and ligation. The resulting RNA transcript may then be converted into double strand DNA useful in a variety of applications including protein expression.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: January 23, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Cheng-Hsien Wu, Lloyd Smith
  • Patent number: 9868939
    Abstract: The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: January 16, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor Slukvin, Akhilesh Kumar
  • Patent number: 9867974
    Abstract: A device is provided for the administration of a compound in a body. The device includes a capsule having a reservoir therein for receiving the compound therein and a delivery instrument for positioning the capsule within the body. The delivery instrument includes a barrel having an interior adapted to receive the capsule therein and a dispersal element interacting with the barrel to selectively expel the capsule therefrom and into the body. A diffusion regulator communicates with the reservoir and controls the diffusion of the compound from the reservoir into the body. A retention structure projects from capsule and is configured to retain the capsule at a desired location within the body. Multiple devices may be used in conjunction to provide a multiplexed point source to administer multiple compounds simultaneously in vivo.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: January 16, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Mark E. Burkard, Jay W. Warrick, David J Guckenberger, Lee G. Wilke
  • Patent number: 9861288
    Abstract: Devices for detecting electrical activity in electrically active biological tissues and methods for using the devices are provided. The devices include an electrode array that is configured for implantation on electrically active biological tissue. The electrode array comprises a plurality of electrode sites comprising one or more layers of transparent, electrically conductive graphene disposed on a transparent substrate.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: January 9, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Zhenqiang Ma, Justin Cole Williams, Dong-Wook Park, Amelia Ann Schendel, Solomon Tadesse Mikael
  • Patent number: 9863923
    Abstract: Methods and compositions for detecting a targeted analyte, such as volatile organic compound (VOCs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. The phase transition can be readily detected with the naked eye. The disclosed methods and compositions may be used in, for example, dosimeters for detecting analyte (e.g., VOC) exposure. Methods and compositions for producing arrays of liquid crystal thin films are also disclosed. The surface between the microwells in a microwell array is coated with a liquid-crystal-phobic material, such as a fluorinated polymer or a fluorinated silane, creating isolated microwell domains that are preferentially wetted by liquid crystal. Liquid crystal can be added to the microwell domains by simple techniques such as spin coating.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: January 9, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas L. Abbott, Marco Antonio Bedolla Pantoja, Xiaoguang Wang
  • Patent number: 9861702
    Abstract: L-Rhamnose antigen-lipid conjugates for recruitment of the immune system to sites of tumor growth for initiating an anti-tumor antigen response. Methods for introducing L-rhamnose antigen-conjugated lipids into cell membranes such that L-rhamnose antigens are displayed on the cell surface. The cells can be tumor cells and more specifically can be melanoma cells. Cells are contacted with one or more L-rhamnose antigen-lipid conjugates such that L-rhamnose antigen-lipid conjugates are inserted into the cell membrane. The cells can be contacted for example by intratumoral injection. Pharmaceutical compositions containing the L-rhamnose antigen-lipid conjugates and therapeutic methods employing the conjugates and compositions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 9, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Laura L. Kiessling, Rachael T. C. Sheridan, Jonathan Hudon
  • Patent number: 9856459
    Abstract: A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable, micro-porous filter membrane and a ligand immobilized on the membrane. The ligand irreversibly and selectively binds viruses. The ligand also has a pKa sufficiently high to repel antibodies via electrostatic charge repulsion.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: January 2, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventor: Mark R. Etzel
  • Patent number: 9859777
    Abstract: An electric machine includes a rotor, a first and second stator, a first and second plurality of permanent magnets, a first and second winding, a third and fourth winding. The first stator and the second stator are mounted axially relative to the rotor. A first permanent magnet and a second permanent magnet of the first plurality of permanent magnets have opposite polarities. A first permanent magnet and a second permanent magnet of the second plurality of permanent magnets have opposite polarities. The first winding, the second winding, the third winding, and the fourth winding are connected in series. An absolute value of an angle offset between the first winding and the third winding and between closest poles of the first plurality of poles and the second plurality of poles is 180 electrical degrees.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: January 2, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bulent Sarlioglu, Ju Hyung Kim, Yingjie Li
  • Patent number: 9855323
    Abstract: A composition and method for immunizing a mammal infected with Mycobacterium are disclosed. The genes gcpE, pstA, kdpC, papA2, impA, umaA1, fabG2_2, aceAB, mbtH2, IpqP, map0834c, cspB, lipN, and map1634 of M. paratuberculosis and the products that they encode are vaccine targets for Johne's and Crohn's disease. Eighteen M. paratuberculosis-specific genomic islands (MAPs) were identified. Three inverted large genomic fragments in M. paratuberculosis (INV) were also identified. These genomic identifiers represent novel virulence determinants that can be used as targets for vaccines and for developments of drugs against Johne's disease. The methods can be used to deliver an immunizing compound to a mammal, to provide an immune response against Johne's or Crohn's disease in the mammal.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: January 2, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Adel Mohammed Talaat
  • Patent number: 9856531
    Abstract: An isolated nucleic acid molecule comprising a polymorphic site selected from the group consisting of positions 164, 269, 284, 407 and 989 of SEQ ID NO: 1, an array or a kit comprising the same. Also provided are a method for detecting single nucleotide polymorphism (SNP) in bovine proteinase inhibitor (PI) gene, a method for haplotyping a bovine cell, a method for progeny testing of cattle based on said haplotyping, a method for selectively breeding of cattle based on haplotyping a parent animal. The present invention further provides a method for testing a dairy cattle for its milk production trait, comprising haplotyping its cells, wherein a cattle having haplotypes 1, 3, 4 or 5 indicates that the cattle has desirable milk production trait. Haplotype 1 indicates that the cattle has the most desirable milk production trait.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: January 2, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventor: Hasan Khatib
  • Patent number: D808390
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: January 23, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: J. Bern Jordan, David P. Kelso, Gregg C. Vanderheiden