Patents Assigned to Wisconsin Alumni Research Foundation
  • Patent number: 11029310
    Abstract: A device and a method for isolating a target from a sample are provided. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes a first plate having a first region for receiving at least a portion of the sample. A second plate is spaced from the first plate by a distance and has a first region for receiving a reagent. A force attracts the target bound solid phase substrate toward the first region of the second plate such that the target bound solid phase substrate in the portion of the sample are drawn through the air gap and into the reagent by the force.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 8, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Scott M. Berry
  • Patent number: 11028235
    Abstract: Methods of selectively modifying lignin, polycarboxylated products thereof, and methods of deriving aromatic compounds therefrom. The methods comprise electrochemically oxidizing lignin using stable nitroxyl radicals to selectively oxidize primary hydroxyls on ?-O-4 phenylpropanoid units to corresponding carboxylic acids while leaving the secondary hydroxyls unchanged. The oxidation results in polycarboxylated lignin in the form of a polymeric ?-hydroxy acid. The polymeric ?-hydroxy acid has a high loading of carboxylic acid and can be isolated in acid form, deprotonated, and/or converted to a salt. The ?-hydroxy acid, anion, or salt can also be subjected to acidolysis to generate various aromatic monomers or oligomers. The initial oxidation of lignin to the polycarboxylated form renders the lignin more susceptible to acidolysis and thereby enhances the yield of aromatic monomers and oligomers obtained through acidolysis.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: June 8, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Shannon S. Stahl, Mohammad Rafiee
  • Patent number: 11028402
    Abstract: Polypeptides comprising maltose/maltotriose transporters are provided. Additionally, polynucleotides, DNA constructs, and vectors encoding a maltose/maltotriose transporter, or yeast cells harboring such polynucleotides are provided. The yeast cell may be a Saccharomyces eubayanus cell modified to increase the expression or transport activity of a maltose/maltotriose transporter at the plasma membrane of the cell. Further, methods are provided for making a fermentation product by culturing any one of the yeast cells described herein with a fermentable substrate. Finally, methods are provided to select for and isolate maltotriose-utilizing strains of Saccharomyces eubayanus.
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: June 8, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Chris Todd Hittinger, EmilyClare Patricia Baker
  • Patent number: 11028418
    Abstract: Recombinant microorganisms configured for enhanced production of compounds such as 2-pyrone-4,6-dicarboxylic acid (PDC) and methods of using the recombinant microorganisms for the production of these compounds. The recombinant microorganisms include one or more modifications that reduce 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) cis-trans isomerase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) methyl esterase activity, and/or vanillate/3-O-methylgallate O-demethylase activity. The recombinant microorganisms can be used to generate PDC from media comprising plant-derived phenolics, such as syringyl phenolics, guaiacyl phenolics, and p-hydroxyphenyl phenolics. The plant-derived phenolics can be derived from pretreated lignin, including depolymerized lignin or other chemically altered lignin.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: June 8, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Daniel R. Noguera, Timothy James Donohue, Jose Perez, Wayne S. Kontur, German Eduardo Umana Chapeton
  • Patent number: 11027140
    Abstract: The invention provides an implantable vagal nerve stimulator having a “passive” generating power source that harvests the stomach's movements to transform kinetic energy to electrical charge without the need for a battery. In this regard, the invention is self-powering and is automatically timed to stomach peristalsis. While sporadic stimulation to the vagal nerve would seem too infrequent to cause weight loss effects, electrical stimulation delivered at the optimal time (e.g., during food consumption) has been found to optimize the effects of vagal nerve stimulation, giving the user's brain a “full stomach” signal before the user over-consumes food.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: June 8, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xudong Wang, Weibo Cai, Guang Yao, Lei Kang
  • Patent number: 11026569
    Abstract: An otoscope provides a disposable speculum sleeve that conducts light to a narrow tip holding an electronic camera. By removing the light source from the tip, the diameter of the tip may be further reduced to allow the space of the ear canal to be shared between the otoscope and a tool such as a curette for removing foreign objects or to permit the tip to navigate around ear obstructions. The sleeve may provide for multidirectional illumination of the ear structure for improved visualization. The tip and sleeve may be flexible for increased patient comfort when using a compact tip design.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: June 8, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James Berbee, Azita Hamedani, Greg Rebella
  • Patent number: 11028113
    Abstract: Cyphomycin, an isolated compound of Formula I or IA is provided. A compound isolated from insect Streptomyces and having a chemical formula of C77H122O26 is also provided. Compositions including Cyphomycin, such as pharmaceutical compositions including effective amounts of Cyphomycin for treating fungal infections such as Candida and Aspergillus, including drug-resistant strains thereof, are also disclosed. Methods of treating fungal infections with Cyphomycin and compositions thereof are disclosed.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: June 8, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy S. Bugni, Monica Tallarico Pupo, David R. Andes, Cameron R. Currie, Humberto Enrique Ortega Dominguez
  • Patent number: 11027975
    Abstract: A method of producing phosphoric acid from at least one mineral containing phosphate and an element which is calcium, magnesium, iron, or aluminum. The method includes contacting the at least one mineral (or a combination of them) with a cation exchanger for a time and at a temperature sufficient to yield phosphoric acid from the mineral.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: June 8, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Phillip Warren Barak
  • Publication number: 20210161487
    Abstract: A system and method for material decomposition of a single energy spectrum x-ray dataset includes accessing the single energy spectrum x-ray dataset, receiving a user-selection of a desired energy for decomposition, and decomposing the single energy spectrum x-ray dataset into material bases as a linear combination of energy dependence function of selected basis materials and the corresponding spatial dependence material bases images.
    Type: Application
    Filed: November 29, 2019
    Publication date: June 3, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Guang-Hong Chen, Yinsheng Li
  • Patent number: 11021441
    Abstract: Substituted hydroquinones and quinones and methods of synthesizing such compounds are disclosed herein. The substituted hydroquinones have the formula: while the substituted quinones have the corresponding oxidized structure (1,4-benzoquinones). One, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety sulfonate moiety is independently a hydrogen, an alkyl or an electron withdrawing group. The substituted hydroquinones and quinones are soluble in water, stable in aqueous acid solutions, and have a high reduction potential in the oxidized form. Accordingly, they can be used as redox mediators in emerging technologies, such as in mediated fuel cells or organic-mediator flow batteries.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: June 1, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Shannon S. Stahl, James B. Gerken
  • Patent number: 11013695
    Abstract: Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: May 25, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Shaoqin Gong, Amr Abdeen, Krishanu Saha, Guojun Chen, Yuyuan Wang, Ruosen Xie
  • Patent number: 11015982
    Abstract: A wavefront sensor system suitable for integration into an integrated circuit light detector may provide for wave angle sensors having varying functional relationships between the wave angle and signal to provide improved dynamic range. These wave angle sensors may be combined with integrated circuit phase angle sensors for a more complete analysis of the waveform.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: May 25, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Zongfu Yu, Soongyu Yi, Dianjing Liu
  • Patent number: 11013403
    Abstract: Provided are methods for assessment of surface rugosity of a layer of live cells using tools that determine contact angle and contact angle hysteresis.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: May 25, 2021
    Assignees: The Regents of the University of California, Wisconsin Alumni Research Foundation
    Inventors: Christopher J. Murphy, Bernardo Yañez-Soto, Vijay Krishna Raghunathan, Nicholas L. Abbott
  • Patent number: 11017597
    Abstract: Systems and methods for modifying and generating quadrilateral meshes for computer graphic structures include obtaining a polygon mesh representing a computer graphic structure, the polygon mesh comprising a plurality of polygonal faces and a plurality of singularities, determining, based on a first singularity of the plurality of vertices, selecting, based on one or more characteristics of the patch, a first minimum singularity template (MST) of a plurality of MSTs each representing a corresponding quadmesh that has three or fewer singularities, and replacing, within the polygon mesh, the patch with the first MST.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: May 25, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Krishnan Suresh, Chaman S. Verma
  • Patent number: 11018552
    Abstract: A first radial force value and a second radial force value is received by a radial magnetic bearing controller. Coefficients are computed for a first equation using the first and second radial force values. The first equation is solved to define first solution values. A second solution value paired with each first solution value is computed using the first radial force value and a respective first solution value to define second solution values. Control current sets are computed for each unique paired solution of the second solution values and the first solution values. Each control current set includes a control current value for each of three control currents. A control current value for each of the three control currents is selected from the control current sets. The control current value for each of the three control currents is output to a respective radial winding of a three-pole radial magnetic bearing.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: May 25, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric Loren Severson, Nicholas Robert Hemenway
  • Patent number: 11011965
    Abstract: A permanent magnet synchronous motor includes a stator, a rotor rotatable relative to the stator, and a magnetic structure with a low coercive force magnet and a high coercive force magnet that are arranged magnetically in series with respect to each other to define a pole-pair of the permanent magnet synchronous motor. A magnetization level of the low coercive force magnet is changeable by a stator current pulse such that a stator magnetomotive force at a rated current is equal to or larger than a product of a magnetic field strength for fully magnetizing the low coercive force magnet and a thickness of the low coercive force magnet.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: May 18, 2021
    Assignees: Nissan Motor Co., Ltd., Wisconsin Alumni Research Foundation
    Inventors: Kensuke Sasaki, Takashi Fukushige, Takashi Katou, Apoorva Athavale, Robert D. Lorenz
  • Patent number: 11008577
    Abstract: Recombinant microorganisms including one or more modifications that enhance lipid production and uses of same for producing lipid. The modifications alter cell surface functions, envelope functions, and other functions. The modifications are capable of converting non-oleaginous microorganisms into oleaginous microorganisms. The lipids produced by some of the recombinant microorganisms are excreted.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: May 18, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Timothy James Donohue, Kimberly Christensen Lemmer, Daniel Noguera, Weiping Zhang
  • Patent number: 11007262
    Abstract: The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant M gene expresses a functional M1 protein and a mutant M2 protein with a deletion of the cytoplasmic tail and either lacking a transmembrane domain or having a mutated transmembrane domain.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: May 18, 2021
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Shinji Watanabe, Tokiko Watanabe, Yoshihiro Kawaoka
  • Patent number: 11008662
    Abstract: Electrochemical cells and photoelectrochemical cells for the reduction of furfurals are provided. Also provided are methods of using the cells to carry out the reduction reactions. Using the cells and methods, furfurals can be converted into furan alcohols or linear ketones.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: May 18, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kyoung-Shin Choi, John James Roylance, Stephen Riley Kubota
  • Patent number: 11012003
    Abstract: A variable speed drive for an electrostatic motor provides feedback control according to rotor position and/or rotor rotational rate deduced from back currents (back-MMF). Extraction of the back currents is performed by a modeling of the stator and the development of isolated stator voltages from plate voltage measurements.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: May 18, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Daniel Colin Ludois, Aditya N. Ghule, Peter Killeen