Patents Assigned to Wisconsin Alumni Research Foundation
  • Patent number: 10294528
    Abstract: Collections of polynucleotides useful estimating breeding value or detecting likelihood of an increased susceptibility to contracting paratuberculosis are disclosed. The polynucleotides are used to detect genomic sequences quantitatively associated with an increased susceptibility to contracting paratuberculosis trait. Methods for using the collections to estimate breeding value or predict likelihood of an increased susceptibility to contracting paratuberculosis are also provided. Kits comprising the collection of polynucleotides are also provided.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: May 21, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Brian W. Kirkpatrick, George W. Shook, Michael T. Collins
  • Patent number: 10297714
    Abstract: Light-emitting devices having a multiple quantum well (MQW) pin diode structure and methods of making and using the devices are provided. The light-emitting devices include: a tunneling heterojunction as a hole injector; an n-type contact; and a light-emitting active region disposed between the tunneling heterojunction and the n-type contact. The tunneling heterojunction facilitates interband tunneling hole injection under bias, whereby electrons in the valence band of a p-type group III-nitride semiconductor tunnel directly into the conduction band of the n-type doped semiconductor, resulting in the generation of holes in the p-type group III-nitride.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: May 21, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Zhenqiang Ma, Dong Liu
  • Patent number: 10293336
    Abstract: A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 21, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, David J. Guckenberger, Jr.
  • Patent number: 10292390
    Abstract: Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: May 21, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Helen Blackwell, Reto Frei, Anthony Breitbach, David M. Lynn, Adam H. Broderick
  • Patent number: 10289604
    Abstract: Aspects of the present invention provide a memory system comprising a plurality of stacked memory layers, each memory layer divided into memory sections, wherein each memory section connects to a neighboring memory section in an adjacent memory layer, and a logic layer stacked among the plurality of memory layers, the logic layer divided into logic sections, each logic section including a memory processing core, wherein each logic section connects to a neighboring memory section in an adjacent memory layer to form a memory vault of connected logic and memory sections, and wherein each logic section is configured to communicate directly or indirectly with a host processor. Accordingly, each memory processing core may be configured to respond to a procedure call from the host processor by processing data stored in its respective memory vault and providing a result to the host processor. As a result, increased performance may be provided.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: May 14, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Karthikeyan Sankaralingam, Jaikrishnan Menon, Lorenzo De Carli
  • Patent number: 10287313
    Abstract: The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2? and/or the 5?-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: May 14, 2019
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Wisconsin Alumni Research Foundation
    Inventors: Masad Damha, Jeremy Lackey, Debbie Mitra, Marvin Wickens, Franco Cerrina, Mark Somoza
  • Patent number: 10286504
    Abstract: Disclosed is a method to make N-acetyl-p-aminophenol. The method includes steps for converting biomass-derived p-hydroxybenzoates to p-hydroxybenzamide, then to p-aminophenol; and then N-acetylating the p-aminophenol.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: May 14, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John Ralph, Steven Karlen, Justin Mobley
  • Publication number: 20190136033
    Abstract: Methods are provided for fabricating functional nanostructures (e.g., nanowires/nanofibers) via chemical vapor deposition polymerization of paracyclophanes or substituted paracyclophanes onto and through a structured fluid, such as a film of liquid crystals, on a substrate. A one-step process is provided that does not require the use of any solid templates, nor does it require any volatile solvents, additives or catalysts. The resulting nanowires/nanofibers can be in the form of aligned nanowires/nanofibers arrays supported on any solid material, in the form of nanofibers mats supported on porous materials, or as individual free-standing nanowires/nanofibers. By using chiral liquid crystals, chiral nanofibers can be fabricated. The functional nanowires/nanofibers can contain one or more type of surface reactive groups that allows for post surface chemical modifications on the nanowires/nanofibers. Such nanostructures can be used in a range of different applications, including in biomedical applications.
    Type: Application
    Filed: April 14, 2017
    Publication date: May 9, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Marco A. BEDOLLA PANTOJA, Nicholas L. ABBOTT, Kenneth CHENG, Joerg LAHANN
  • Patent number: 10282899
    Abstract: In accordance with some embodiments, systems, methods and media for simulating deformation of an elastic body are provided. In some embodiments, a method comprises: determining for each macroblock, a stiffness matrix Ki of a portion of a model of a non-linear elastic solid partitioned into cells; converting Ki into block form to include a submatrix KIiIi for nodes between internal cells of a first macroblock; determining at least a portion of KIiIi?1; receiving input corresponding to force applied to cells of the model; determining displacements of exterior nodes of the first macroblock using the input and the portion of KIiIi?1; determining displacements of interior nodes of the first macroblock using the input and the displacements of exterior nodes; determining updated positions of the cells based on the displacements of the exterior nodes; and, causing the model to be presented using the updated positions.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: May 7, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nathan M. Mitchell, Eftychios D. Sifakis, Michael S. Doescher
  • Patent number: 10280405
    Abstract: The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: May 7, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James E. Gern, Yury A. Bochkov, Ann C. Palmenberg
  • Patent number: 10284339
    Abstract: A receiver detects a plurality of information symbols. A first signal and a second signal are received from a first transmitted signal and a second transmitted signal, respectively, transmitted by a first plurality of antennas and received by a second plurality of antennas connected to the receiver. The second signal is received after the first signal. The receiver spatially filters the first signal using a spatial filter matrix. The receiver computes a conjugate of the first filtered signal to define a conjugate first signal, and spatially filters a second signal using the spatial filter matrix. The receiver computes a Hadamard product of the first filtered signal and the conjugate first signal to define a differential measurement signal. The receiver detects the plurality of information symbols from the differential measurement signal.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: May 7, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Akbar M. Sayeed, John H. Brady
  • Patent number: 10273511
    Abstract: Enzymes for producing non-straight-chain fatty acids, microorganisms comprising the enzymes, and in vivo and in vitro uses of the enzymes. Provided are enzymes capable of producing various non-straight-chain fatty acids, including branched-chain fatty acids, cyclic fatty acids, and furan-containing fatty acids. The enzymes include RSP2144, RSP1091, and RSP1090 from Rhodobacter sphaeroides and homologs thereof. The enzymes can be purified to produce non-straight-chain fatty acids in vitro or expressed in microorganisms to produce non-straight-chain fatty acids in vivo. The microorganisms can be fine-tuned to produce a specific type of non-straight-chain fatty acid by expressing, overexpressing, or deleting the enzymes in various combinations.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: April 30, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Rachelle A. S. Lemke, Timothy James Donohue, Joshua J. Coon, Amelia C. Peterson, Michael S. Westphall
  • Patent number: 10277147
    Abstract: Triboelectric nanogenerators that operate in a vertical contact separation mode and methods for fabricating the triboelectric generators are provided. Also provided are methods for using the triboelectric nanogenerators to harvest mechanical energy and convert it into electric energy. In the TENGs, one or both of the triboelectrically active layers comprises a cellulose that has been chemically treated to alter its electron affinity.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: April 30, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xudong Wang, Zhiyong Cai, Chunhua Yao, Alberto Hernandez, Yanhao Yu
  • Publication number: 20190117839
    Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.
    Type: Application
    Filed: March 14, 2017
    Publication date: April 25, 2019
    Applicants: Wisconsin Alumni Research Foundation, Arkansas State University - Jonesboro, Worcester Polytechnic Institute
    Inventors: William L. MURPHY, Gianluca FONTANA, Joshua GERSHLAK, Glenn GA UDETTE, Pam WEATHERS, Tanja DOMINKO, Marsha ROLLE, Sarah HERNANDEZ, Carol CRAMER, Fabricio MEDINA-BOLIVAR
  • Patent number: 10265398
    Abstract: Alkylphosphocholine analogs incorporating a chelating moiety that is chelated to gadolinium are disclosed herein. The alkylphophocholine analogs are compounds having the formula: or a salt thereof. R1 includes a chelating agent that is chelated to a gadolinium atom; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is —H, —OH, —COOH, —COOX, —OCOX, or —OX, wherein X is an alkyl or an arylalkyl; R2 is —N+H3, —N+H2Z, —N+HZ2, or —N+Z3, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2. The compounds can be used to detect solid tumors or to treat solid tumors. In detection/imaging applications, the gadolinium emits signals that are detectable using magnetic resonance imaging. In therapeutic treatment, the gadolinium emits tumor-targeting charged particles when exposed to epithermal neutrons.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: April 23, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jamey Weichert, Anatoly Pinchuk, Wolfgang Axel Tomé
  • Patent number: 10261152
    Abstract: A system and method are provided for determining B1 inhomogeneities or creating a T1 map of a subject using a magnetic resonance imaging (MRI) system that is corrected for an influence of a presence of fat and a presence of iron in the subject on T1 weighting. The method includes controlling the MRI system using a single pulse sequence to acquire, from the subject, a plurality of datasets with varied T1 weighting created by varying at least one of a repetition time (TR) and a flip angle (FA) for repetitions of the single pulse sequence. The method also includes using an MR signal model and the plurality of datasets, estimating B1 inhomogeneities or generating a T1 map of the subject that is corrected for an influence of a presence of fat and a presence of iron in the subject on T1 weighting in the plurality of datasets.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: April 16, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Scott B. Reeder, Xiaoke Wang, Diego Hernando
  • Patent number: 10260047
    Abstract: A purified human cell population of subsets of angiohematopoietic progenitor cells, wherein the population is at least 94% pure and wherein the cells are selected with cell markers selected from the group of KDR, APLNR, VE-cadherin, PDGFR?, CD31, CD235a, CD73, CD43, and CD41a.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: April 16, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Igor I. Slukvin, Maksym A. Vodyanyk, Kyung-Dal Choi
  • Patent number: 10261161
    Abstract: A phantom for use with magnetic resonance imaging (“MRI”) and, in particular, for calibrating quantitative diffusion MRI is provided. In general, the phantom includes a solution composed of a solvent that has diffusivity value higher than that of water, and a solute that when added to the solvent reduces the diffusivity of the solution. By varying the combined concentration of the solvent and solute, the diffusivity of the solution can be controlled to fall within a range of diffusivity values found in biological tissues in a variety of different physiological conditions or tissue environments.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: April 16, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xiaoke Wang, Scott Brian Reeder, Diego Hernando
  • Patent number: 10258695
    Abstract: Methods and reagents for enhancing cellular uptake of a cargo molecule by covalently bonding optionally-substituted fluorenyl groups to the cargo molecules, where cellular uptake includes at least partial uptake into the cytosol. Useful fluorenylation reagents include those of formula: and salts thereof where variables are as defined. Cargo molecules include peptides and proteins. Also provided are fluorenylated cargo molecules, including fluorenylated peptides and proteins.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: April 16, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Kristen A. Andersen
  • Patent number: 10253376
    Abstract: LAMP primer sets for detecting eight mastitis pathogens are disclosed. Methods and kits of using the primer sets to simultaneously detect at least two of the eight mastitis pathogens are also described.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: April 9, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Doerte Doepfer, Kelly Anklam