Patents Assigned to Wisconsin Alumni Research Foundation
  • Patent number: 10046000
    Abstract: Disclosed are methods of administering 2-methylene-19-nor-(20S)-1?,25-dihydroxyvitamin D3 to treat and/or prevent secondary hyperparathyroidism and/or its accompanying symptoms in a subject having or at risk for developing secondary hyperparathyroidism.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: August 14, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Lori A. Plum, Julia B. Zella, Margaret Clagett-Dame
  • Patent number: 10045696
    Abstract: Fluorescent markers used to identify a tissue may be imaged in a bright environment by synchronizing the imaging process with rapidly switched ambient lighting so that imaging occurs in phase with a switching off of the ambient lighting. In this way, valuable fluorescent imaging may be performed in an environment that appears to be brightly illuminated, for example in the area of a surgical suite.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: August 14, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Thomas Mackie, Adam Uselmann, Andreas Velten, Surendra Prajapati, Kevin Eliceiri
  • Patent number: 10047113
    Abstract: The invention relates to nucleic acids encoding a feruloyl-CoA:monolignol transferase and the feruloyl-CoA:monolignol transferase enzyme that enables incorporation of monolignol ferulates, for example, including p-coumaryl ferulate, coniferyl ferulate, and sinapyl ferulate, into the lignin of plants.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 14, 2018
    Assignees: Board of Trustees of Michigan State University, The University of British Columbia, Wisconsin Alumni Research Foundation
    Inventors: Curtis Wilkerson, John Ralph, Saunia Withers, Shawn D. Mansfield
  • Patent number: 10040062
    Abstract: A device and method are proved for transferring a target from a first location to a second location. The target is bound to solid phase substrate to form a target bound solid phase substrate. The device includes transfer surface for receiving the target bound solid phase substrate thereon for transfer. The transfer surface movable between a first position wherein the transfer surface is aligned with the first location and spaced therefrom by a distance and a second position wherein the transfer surface is aligned with the second location. An alignment structure aligns the transfer surface with respect to the second location, with the transfer surface in the second position. A force is movable between an attraction position wherein the target bound solid phase substrate are drawn toward the transfer surface and a discharge position wherein the target bound solid phase substrate are free of the force.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: August 7, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Patent number: 10039860
    Abstract: A bioscaffold made from an isolated cardiac fibroblast-derived 3-dimensional extracellular matrix (ECM) is disclosed. The bioscaffold can be used as an epicardial patch for the delivery of therapeutic cells into myocardial tissue. Methods of making the 3-dimensional extracellular matrix using cultured cardiac fibroblasts are also disclosed.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: August 7, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric G. Schmuck, Kurt W. Saupe
  • Patent number: 10042025
    Abstract: A system and method is provided for producing a map of a static magnetic field (B0) of a magnetic resonance imaging system. The method includes forming a first dataset by acquiring, with the MRI system, a first plurality of different echo signals occurring at a respective plurality of different echo times. The method also includes forming a second dataset by acquiring, with the MRI system, a second plurality of different echo signals occurring at a respective plurality of different echo times. The second dataset includes signals resulting from a magnetization transfer (MT) between free water and bound molecules. The method further includes generating MT-weighted maps using the first dataset and the second dataset, determining, using the MT-weighted maps, a phase difference between the first plurality of different echo signals, and using the phase differences, generate a corrected map of the static magnetic field (B0) of the MRI system.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: August 7, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Alexey A. Samsonov
  • Patent number: 10044085
    Abstract: Stretchable high frequency transmission lines and high-frequency filters comprising the transmission lines are provided. The transmission lines provide low power loss, even at microwave and millimeter wave frequencies. The transmission lines are thin and flexible and can be stretched without a significant degradation of their scattering parameters. As a result, the transmission lines have applications as interconnects in stretchable and flexible integrated circuits (IC) and circuit device components, such as flexible transistors and flexible diodes.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: August 7, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Zhenqiang Ma, Yei Hwan Jung, Juhwan Lee, Shaoqin Gong
  • Publication number: 20180216083
    Abstract: The invention generally relates to engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same. More specifically, the invention relates in part to compositions including engineered prephenate dehydrogenases (PDH) polypeptides and engineered arogenate dehydrogenase (ADH) polypeptides with altered substrate preferences and tyrosine sensitivities and methods of using the same.
    Type: Application
    Filed: January 29, 2018
    Publication date: August 2, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Hiroshi A. Maeda, Craig Albert Schenck
  • Patent number: 10034932
    Abstract: The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: July 31, 2018
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Christopher W. Olsen, Gabriele A. Landolt, Alexander I. Karasin
  • Patent number: 10036084
    Abstract: Solid immiscible alloys and methods for making the solid immiscible alloys are provided. The microstructure of the immiscible alloys is characterized by a minority phase comprising a plurality of particles of an inorganic material dispersed in a majority phase comprising a continuous matrix of another inorganic material. The methods utilize nanoparticles to control both the collisional growth and the diffusional growth of the minority phase particles in the matrix during the formation of the alloy microstructure.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: July 31, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xiaochun Li, Lianyi Chen, Jiaquan Xu
  • Patent number: 10036796
    Abstract: Phantoms for use in magnetic resonance imaging (“MRI”) and, in particular, for use in quantifying fat concentration, iron concentration, or both, are provided. The phantoms are constructed to accurately reflect in vivo magnetic resonance signal behavior in the presence of both fat and iron. The phantoms described here can thus be used for phantom-based validation of MRI techniques for the joint quantification of fat and iron concentration, for phantom-based validation of MRI techniques for quantifying fat concentration in the presence of iron overload, and for phantom-based validation of MRI techniques for quantifying iron concentration given the confounding presence of fat.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: July 31, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Scott Brian Reeder, Diego Hernando, Samir Sharma
  • Publication number: 20180207090
    Abstract: Described is an intra-mammary teat sealant and a corresponding method of forming a physical barrier in the teat canal of a non-human animal for prophylactic treatment of mammary disorders during the animal's dry period. The method includes the step of infusing a teat seal formulation including a metal salt in a glyceride-containing gel base into the teat canal of the animal. The method also prevents the formation of black spot defect in dairy products, especially cheddar cheese, made from the milk of animals so treated.
    Type: Application
    Filed: March 21, 2018
    Publication date: July 26, 2018
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventor: Scott A. Rankin
  • Patent number: 10028904
    Abstract: The present invention includes a transdermal composition which contains a pharmaceutically effective amount of a cannabinoid for delivery of the cannabinoid to the bloodstream of a user. The composition may comprise the following components: a surfactant-lecithin organogel; and a cannabinoid. The composition may also comprise an exogenous terpene. The cannabinoid is capable of diffusing from the composition into the bloodstream of the user, and may be used in methods for treating a patient suffering from a condition such as pain, nausea and emesis, convulsions, muscle spasm, inflammation, depression, and cachexia.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: July 24, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicole Smith, Noel Erwin Palmer
  • Publication number: 20180201961
    Abstract: Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an R-specific enoyl-CoA hydratase gene, a PHA polymerase gene, a thioesterase gene, and an acyl-CoA-synthetase gene. The cells further have one or more genes functionally deleted. The functionally deleted genes include such genes as an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase, and a 3-ketoacyl-CoA thiolase gene. The recombinant cells are capable of using producing polyhydroxyalkanoates with a high proportion of monomers having the same carbon length from non-lipid substrates, such as carbohydrates.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 19, 2018
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Brian Frederick Pfleger, Daniel E. Agnew
  • Publication number: 20180202939
    Abstract: Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the absence of the target.
    Type: Application
    Filed: December 20, 2017
    Publication date: July 19, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Sundaram Gunasekaran, Seokwon Lim
  • Patent number: 10022450
    Abstract: A chimeric toxin is disclosed comprising a peptide ligand specifically targeting neurons involved in pain processing; and a clostridial neurotoxin light chain, wherein the ligand is linked to the light chain. The methods of preparing such chimeric toxin and the method of using the chimeric toxin to regulate pain transmission are also disclosed.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: July 17, 2018
    Assignees: Wisconsin Alumni Research Foundation, The Regents of the University of California
    Inventors: Eric A. Johnson, Sabine Pellett, William H. Tepp, Tony L. Yaksh, Marc Marino, Qinghao Xu
  • Patent number: 10024870
    Abstract: Methods and compositions relating to motor neurons derived from induced pluripotent stem cells of subjects having a neurodegenerative disease, where the motor neurons exhibit phenotypes characteristic of the neurodegenerative disease, are provided herein. In particular, the present invention provides methods for screening putative therapeutic agents and methods for diagnosing living subjects as having a neurodegenerative disease. In addition, the present invention provides therapeutic gene transfer methods for treating or preventing a neurodegenerative disease in a subject in need thereof.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 17, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Hong Chen
  • Patent number: 10020717
    Abstract: An electric machine includes a rotor, a first stator, and a second stator. The rotor includes a rotor core and a first and a second plurality of poles mounted to extend radially from the rotor core. The first stator and the second stator each include a stator core, a plurality of teeth mounted to extend from the stator core, and a plurality of permanent magnets mounted as first spokes within the plurality of teeth. The stators are mounted radially relative to a first side of the rotor and separated by a first air gap between the plurality of poles and the plurality of teeth. At least four windings are connected in series and wound about the plurality of teeth. A first flux linkage in a first pair of series connected windings is a mirror image of a second flux linkage in a second pair of series connected windings.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: July 10, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bulent Sarlioglu, Yingjie Li
  • Patent number: 10017569
    Abstract: The present disclosure is directed to interleukin-10 (IL-10) peptides and isolated antibodies that specifically bind to the IL-10 peptides. The IL-10 peptides and the isolated antibodies may be administered alone or as an animal feed additive to treat gastrointestinal protozoan infection in animals.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: July 10, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jordan Marshall Sand, Mark Eric Cook
  • Patent number: 10017771
    Abstract: Some HBL and NHE enterotoxins are known to cause food-borne diseases in humans. Enterotoxin-deficient mutants of member strains of the Bacillus cereus group that do not produce HBL, HBLa1, HBLa2, or NHE enterotoxins are disclosed. Enterotoxin-deficient mutants are suitable for use as biocontrol agents. Methods for making the mutants and for using the mutants are described.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: July 10, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo Emily Handelsman, Amy Klimowicz, Changhui Guan