Patents Assigned to Wisconsin Alumni Research Foundation
  • Publication number: 20200199185
    Abstract: Methods of purifying mucin, purified mucin, and products comprising the purified mucin. The methods include combining a mucin-containing substance with water and one or more purification agents to form a purification mixture, incubating the purification mixture for a time sufficient to form a mucin precipitate in a liquid phase, and separating the mucin precipitate from the liquid phase. The purification agents include one or more of a surfactant, a chelating agent, and a protic solvent. The mucin purified from the methods can be used alone or in combination with a biopolymer such as a tannin and chitosan and can be used to generate materials in the form of a gel, a foam, a film, or a powder.
    Type: Application
    Filed: December 20, 2019
    Publication date: June 25, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Jess Dreher Reed, Sergio Madrigal-Carballo, Michael Allen Polewski, Christian Gerald Krueger, Emilia Alfaro-Viquez
  • Patent number: 10689631
    Abstract: Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ ID NO:1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell, and host cells transformed to contain the gene constructs.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: June 23, 2020
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, THE PENN STATE RESEARCH FOUNDATION
    Inventors: Brian F. Pfleger, Nestor Jose Hernandez-Lozada, Costas Maranas, Matthew Grisewood
  • Patent number: 10682415
    Abstract: The invention provides a drug delivery system for a combination of therapeutic agents. The system includes a water soluble biodegradable ABA-type triblock copolymer that possesses thermosensitive gelation properties. The system can form a stable thermogel that includes a combination of therapeutic agents including, for example, rapamycin, paclitaxel, and 17-AAG. After administration to a subject, the drugs are released at a controlled rate from the thermogel, which biodegrades into non-toxic components. The polymer system can also function to increase the solubility and stability of drugs in the composition.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: June 16, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Glen S. Kwon, Hyunah Cho
  • Patent number: 10677874
    Abstract: A system and method is provided to acquire images of a subject having received a tissue soluble hyperpolarized gas into the airways. The method includes performing a pulse sequence including (i) for each effective repetition time (TReff), acquiring at least one gas-phase dataset and at least one dissolved-phase dataset, wherein a gas-phase echo time (TEGas) of the at least one gas-phase dataset and a dissolved-phase echo time (TEDissolved) of the at least one dissolved-phase dataset are selected to isolate gas-phase contamination of the dissolved-phase dataset from dissolved-phase components in the dissolved-phase dataset.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: June 9, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Sean Fain, Andrew Hahn, Jeffrey Kammerman
  • Patent number: 10678042
    Abstract: Method for imaging regions of a sample using a light source and an optical detection means and at least one device for moving the sample in three dimensions, comprising the following method steps: a) introducing at least one magnetic element into the sample, b) applying a magnetic field by means of the at least one device for moving the sample in three dimensions, the magnetic field interacting with the at least one magnetic element introduced into the sample, c) arranging the region of the sample in a radiation region of the light source and in a detection region of the detection means, d) emitting first light beams from the light source onto the sample, e) generating second light beams by means of the sample, f) recording an image of a region of the sample by capturing a proportion, incident on the detection means from the sample, of the second light beams, g) moving the at least one magnetic element and the sample containing this at least one magnetic element by varying the magnetic field, h) repeating ste
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: June 9, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jan Huisken, Gopi Shah
  • Patent number: 10675241
    Abstract: Described herein are methods of use of purified preen oil, food and feed compositions containing purified preen oil, food and feed additives containing purified preen oil, and pharmaceutical compositions containing purified preen oil. Methods include treatment of chronic joint inflammation in humans and animals by orally administering purified preen oil. Also included are methods of feeding a growing fish by feeding the feeding the growing fish purified preen oil in amounts effective to improve survival and/or stimulate growth in the growing fish. Further included are methods of feeding live prey organisms purified preen oil, and feeding the live prey organisms to growing fish.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: June 9, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Mark E. Cook, Jordan Sand, Jake M. Olson, Terence P. Barry
  • Patent number: 10676449
    Abstract: Compounds of Formula I: wherein: R1 and R1? are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R1 and R1? are not simultaneously hydrogen; R2 and R2? hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, carboxy, carboxyalkyl, amido, N-alkylamido, N,N-dialkylamido, carbamoyloxy, N-alkylcarbamoyloxy, and N,N-dialkylcarbamoyloxy, provided that that R2 and R2? are not simultaneously hydrogen; R3 is selected from hydrogen, C1 to C12 linear or branched alkyl, and nitrogen protecting groups; X is oxygen or nitrogen; when X is oxygen, R4 is absent; and when X is nitrogen, R4 is selected from H, C1-to-C12 linear or branched alkyl, and nitrogen protecting groups.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: June 9, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jennifer M. Schomaker, Eileen G. Burke
  • Patent number: 10676793
    Abstract: Nucleic acid molecules comprising a SNP site at position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), which SNP indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the SNPs, a method for progeny testing of cattle, and a method for selectively breeding of cattle.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: June 9, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Hasan Khatib
  • Patent number: 10676363
    Abstract: Electrically conductive aerogel films, electrodes composed of the electrically conductive aerogel films, and supercapacitors incorporating the electrodes are provided. The aerogel films include reduced graphene oxide particles in combination with metal oxynitride fibers. By including cellulosic nanofibrils in the aerogels, the films can be made mechanically flexible and free-standing.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: June 9, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Shaoqin Gong, Qifeng Zheng
  • Patent number: 10676392
    Abstract: Described are carbon nanotube dispersions containing single-walled carbon nanotubes dispersed in a dispersant solution comprising a solvent (water, organic polar protic solvents, and/or organic polar aprotic solvents), and an azo compound. The single-walled carbon nanotubes are not cross-linked with covalent bonds. The dispersions are useful for fabricating transparent conductive thin films on flexible and inflexible substrates. Methods for making the transparent conductive thin films are also described.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: June 9, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Sundaram Gunasekaran, Ashok Kumar Sundramoorthy
  • Patent number: 10669639
    Abstract: Electrochemical cells for the oxidation of 5-hydroxymethylfurfural are provided. Also provided are methods of using the cells to carry out the oxidation reactions. The electrochemical cells and methods use catalytic copper-based anodes to carry out the electrochemical oxidation reactions.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: June 2, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kyoung-Shin Choi, Dohwan Nam
  • Patent number: 10668017
    Abstract: The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. The hydrogel may be a di-or tri-block copolymer comprising one block of poly(ethylene glycol) (PEG) and one or two blocks of poly(lactic-co-glycolic acid) (PLGA). The unimolecular micelle may include three domains: a dendritic polymer core, hydrophobic block polymers (e.g., PVL, PVCL, and/or PCL) attached to the core and PEG attached to the hydrophobic block polymers.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: June 2, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: K. Craig Kent, Shaoqin Gong, Xudong Shi, Guojun Chen, Lian-Wang Guo
  • Patent number: 10660874
    Abstract: An isolated or synthesized compound of Formula I and salts thereof are provided. A compound isolated from Actinomadura and having a chemical formula of C38H60O12 is also provided. Compositions including the compounds and methods of using the compounds to treat bacterial infections including gram positive infections such as C. difficile are also disclosed.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: May 26, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Timothy Scott Bugni, Thomas Philip Wyche, Douglas R. Braun, Jeffrey S. Piotrowski, Nasia Safdar
  • Patent number: 10660860
    Abstract: Provided herein are peptides comprising an amino acid sequence having at least about 85% sequence identity to RYRPRAPIIAVT (SEQ ID NO: 1). These cationic peptides inhibit PKM2 methylation and may be used in the treatment of breast cancer and other diseases or conditions in which PKM2 is overexpressed. Such PKM2 peptides may be delivered to cancer cells using pH sensitive unimolecular nanoparticles comprising anionic polymers.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: May 26, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Shaoqin Gong, Wei Xu, Yuyuan Wang, Fabao Liu
  • Publication number: 20200155103
    Abstract: A system and method are provided for determining vascular velocity using non-invasively acquired medical images. The method includes reconstructing CT angiography (CTA) data into a plurality of images of the subject by producing a composite image using the CTA data corresponding to a set of the plurality of view angles, backprojecting each view angle in the CTA data and weighting a value backprojected into at image pixel by an attenuation value of a corresponding pixel in the composite image, and summing backprojected values for each image pixel to produce a CT image of the subject. The method also includes determining a flow direction or a velocity of flow within a vessel, calculating, using the flow direction or velocity, a pressure in the vessel, and generating a quantitative map of the subject indicating the flow direction, velocity, or pressure in the vessel against an image of the subject including the vessel.
    Type: Application
    Filed: November 15, 2019
    Publication date: May 21, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Charles A. Mistretta, Martin Wagner
  • Publication number: 20200161010
    Abstract: The invention relates to SiC ceramic matrix composite (CMC) claddings with metallic, ceramic and/or multilayer coatings applied on the outer surface for improved corrosion resistance and hermeticity protection. The coating includes one or more materials selected from FeCrAl, Y, Zr and Al—Cr alloys, Cr2O3, ZrO2 and other oxides, chromium carbides, CrN, Zr- and Y-silicates and silicides. The coatings are applied employing a variety of known surface treatment technologies including cold spray, thermal spray process, physical vapor deposition process (PVD), and slurry coating.
    Type: Application
    Filed: November 20, 2018
    Publication date: May 21, 2020
    Applicants: Westinghouse Electric Company LLC, Wisconsin Alumni Research Foundation
    Inventors: Edward J. Lahoda, Peng Xu, Robert L. Oelrich, JR., Hwasung Yeom, Kumar Sridharan
  • Publication number: 20200158607
    Abstract: The present invention provides methods for controllably forming a layer of amorphous ice and other amorphous solids on a substrate, and also provides cryoelectron microscopy (cryo-EM) sample preparation methods and systems that utilize in vacuo formation of amorphous ice and other solids. Formation of the amorphous solid layer can be independent of the deposition of sample molecules to be analyzed using electron microscopy, and allows for the generation of a uniformly thick layer. Optionally, mass spectrometry instruments are used to generate and purify molecules deposited on the generated amorphous solid layer. The techniques and systems described herein can deliver near ideal cryo-EM sample preparation to greatly increase resolution, sensitivity, scope, and throughput of cryo-EM protein imaging, and therefore greatly impact the field of structural biology.
    Type: Application
    Filed: July 6, 2018
    Publication date: May 21, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Joshua COON, Michael WESTPHALL
  • Patent number: 10655233
    Abstract: Electrochemical and photoelectrochemical cells for the oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid and/or 2,5-diformylfuran are provided. Also provided are methods of using the cells to carry out the electrochemical and photoelectrochemical oxidation of 5-hydroxymethylfurfural to 2,5-furandicarboxylic acid and/or 2,5-diformylfuran.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: May 19, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Kyoung-Shin Choi, Hyun Gil Cha
  • Publication number: 20200150106
    Abstract: This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.
    Type: Application
    Filed: January 16, 2020
    Publication date: May 14, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Michael R. Sussman, J. Leon Shohet, Faraz A. Choudhury, Joshua M. Blatz, Benjamin B. Minkoff, Daniel I. Benjamin
  • Patent number: 10649240
    Abstract: Switches for electromagnetic radiation, including radiofrequency switches and optical switches, are provided. Also provided are methods of using the switches. The switches incorporate layers of high quality VO2 that are composed of a plurality of connected crystalline VO2 domains having the same crystal structure and orientation.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: May 12, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Zhenqiang Ma, Chang-Beom Eom, Jaeseong Lee, Daesu Lee, Sang June Cho, Dong Liu