Patents Assigned to Wisconsin Alumni Research Foundation
  • Publication number: 20180172598
    Abstract: Nanoreactors comprising a metal precursor in a carrier are provided. In some embodiments, upon exposure to heat, the metal precursor forms nanoparticles that can be detected, e.g., by detecting a color change in the nanoreactor and/or by detecting the number and/or size and/or size distribution and/or shape of the nanoparticles. The nanoreactors can be used, in some embodiments, as time-temperature indicators for perishable goods.
    Type: Application
    Filed: December 15, 2017
    Publication date: June 21, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Sundaram Gunasekaran, Seok won Lim
  • Patent number: 10002445
    Abstract: A system and method are provided for medical imaging that includes acquiring, during a common imaging acquisition process, rotational, x-ray volume image data and x-ray tomosynthesis image data from a subject. The method includes reconstructing a time-resolved three-dimensional (3D) image volume from the rotational, x-ray volume image data and producing a four-dimensional (4D) image series of the subject with resolved overlapping features by selectively combining the time-resolved 3D image volume and the x-ray tomosynthesis imaging data.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: June 19, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Charles A. Mistretta, Michael A. Speidel, Jordan Slagowski
  • Patent number: 10003228
    Abstract: A rotor includes pole portions, a first permanent magnet, a second permanent magnet, and a third permanent magnet. Each pole portion includes a center, a back, and a front rotor core portion. A first slot is embedded in the center rotor core portion. A second slot is embedded in the back rotor core portion. A third slot is embedded in the front rotor core portion. The center rotor core portion is mounted axially between the front rotor core portion and the back rotor core portion. The permanent magnets are mounted, respectively, in the slots of each pole portion. A maximum length of the first permanent magnet is greater than twice a maximum length of the second permanent magnet. The maximum length of the second permanent magnet is equal to a maximum length of the third permanent magnet. The permanent magnets are aligned relative to a pole axis of each pole portion.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: June 19, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Thomas A. Lipo, Zhentao Stephen Du
  • Patent number: 9993206
    Abstract: A sensitive measure of brain condition simultaneously evaluates multiple measurements of water diffusion in brain tissue combined so as to correct for covariance between the different data types of the multipoint measurements and compares the multipoint measurements to a corresponding multipoint measure representing normal brain tissue to provide a distance indicating a likelihood of atypical brain conditions.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: June 12, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Andrew Lafayette Alexander, Douglas Carl Dean, III, Gregory Russel Kirk, Brittany Gail Travers
  • Patent number: 9994819
    Abstract: The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: June 12, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peiman Hematti, Jaehyup Kim
  • Patent number: 9993534
    Abstract: A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: June 12, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Bruce Steven Klein, Theodore Tristan Brandhorst, Thomas Sullivan, Marcel Wuethrich
  • Publication number: 20180153928
    Abstract: Non-natural oligomers have recently shown promise as functional analogues of lung surfactant proteins B and C (SP-B and SP-C), two helical and amphiphilic proteins that are critical for normal respiration. The generation of non-natural mimics of SP-B and SP-C has previously been restricted to step-by-step, sequence-specific synthesis, which results in discrete oligomers that are intended to manifest specific structural attributes. Presented herein an alternative approach to SP-B mimicry that is based on sequence-random copolymers containing cationic and lipophilic subunits. These materials, members of the nylon-3 family, are prepared by ring-opening polymerization of ?-lactams. The best of the nylon-3 polymers display promising in vitro surfactant activities in a mixed lipid film. Pulsating bubble surfactometry data indicate that films containing the most surface-active polymers attain adsorptive and dynamic-cycling properties that surpass those of discrete peptides intended to mimic SP-B.
    Type: Application
    Filed: February 5, 2018
    Publication date: June 7, 2018
    Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION, NORTHWESTERN UNIVERSITY
    Inventors: Samuel H. Gellman, Shannon S. Stahl, Brendan P. Mowery, Annelise Barron, Michelle Dohm
  • Publication number: 20180155732
    Abstract: Provided herein are constructs for genome editing or genetic engineering its fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a polynucleotide encoding a thymidine kinase operably connected to a promoter, suitably a constitutive promoter; a polynucleotide encoding an endonuclease operably connected to an inducible promoter; and a recognition site for the endonuclease. The constructs may also include selectable markers for use in selecting recombinations.
    Type: Application
    Filed: January 24, 2018
    Publication date: June 7, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Christopher Todd Hittinger, William Gerald Alexander
  • Patent number: 9988633
    Abstract: Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression of Exosc10, such as inhibitory nucleic acid molecules, produce an increase in red blood cell production in the individual.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: June 5, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Emery H. Bresnick, Yoon A. Kang, Skye McIver
  • Patent number: 9988434
    Abstract: Novel collagen-mimetic peptides are disclosed comprising the formula (Xaa-Yaa-Gly)n, where the amino acid at one of the Xaa positions is substituted with a homocysteine residue. Also disclosed are multi-stranded novel collagen-mimetic peptides comprising a first strand as described above that is covalently bonded with a disulfide bridge to a second strand comprising the formula (Xaa-Yaa-Gly)m, where the amino acid at one of the Yaa positions is substituted with a cysteine residue. Disulfide formation between the terminal thiol sulfur of the homocysteine residue of the first strand and the terminal thiol sulfur of the cysteine residue of the second strand reveals unstrained bridges that enhance the structure and substantially improve the stability of collagen triple helices as compared to other possible disulfide or thioether bridges.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: June 5, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Ismet C. Tanrikulu
  • Patent number: 9988665
    Abstract: A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase SIRT1, and to identify the most efficiently deacetylated peptide sequences. The method can be also used to screen a combinatorial H4 histone N-terminal tail peptide library to examine the binding preferences of a ?-phos (S1) H4 antibody toward all known possible H4 histone modification states.
    Type: Grant
    Filed: August 12, 2011
    Date of Patent: June 5, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: John M. Denu, Adam L. Garske
  • Patent number: 9989613
    Abstract: A system and method for accelerated magnetic resonance imaging (MRI) includes controlling an RF system of an MRI system to acquire coil calibration data from a subject including a material causing inhomogeneities in a static magnetic field of the MRI system when arranged in the bore of the MRI system. After acquiring the coil calibration data, the RF system is controlled to acquire imaging data from the subject at multiple different resonance frequency offsets. The spectral bin images relate specific resonance frequencies to distinct spatial locations in the static magnetic field of the MRI system. An image of the subject is reconstructed from the imaging data using coil calibration data and the spectral bin data to provide spatial encoding of the image.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: June 5, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Curtis N. Wiens, Nathan S. Artz
  • Patent number: 9981312
    Abstract: A 3-D printer scalable to large sizes employs a combination of mechanical and electrical scanning of a linear array of electron beams that operate to melt material of a powder bed. A housing holding the electron beam sources may be maintained at a high vacuum and positioned close to a print surface to minimize electron travel in a softer vacuum surrounding a print bed.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: May 29, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Thomas Rockwell Mackie, Brandon Joseph Walker
  • Patent number: 9976120
    Abstract: A scaffold for neurons consists of tubes sized to promote neural growth through the tubes. The tubes may be fixed to a substrate providing electrical or optical paths out from the interior of the tubes from sensors or stimulating probes at one or more locations along the length of the coaxial axons. Steering electrodes at spaces between tubes may be used to selectively promote the growth of interconnections of different axons in a one, two, or three-dimensional fashion.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: May 22, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert H. Blick, Justin Williams, Minrui Yu, Yu Huang
  • Patent number: 9976182
    Abstract: Single nucleotide polymorphic sites at positions 19069 and 25402 of the bovine STAT3 gene are associated with improved fertilization rate and/or improved embryo survival rate. The interactions between these two polymorphisms, and between them and the bovine STAT1 gene and fertilization and early embryonic survival rates were also disclosed. The interactions between STAT3 SNPs, and between STAT1 and STAT3 SNP19069 were highly significant for embryonic survival rate. Also disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: May 22, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Hasan Khatib
  • Patent number: 9979323
    Abstract: A variable speed drive for an electrostatic motor provides feedback control by conversion of measured current phases provided to the motor into a vector in a rotating rotor framework. This vector is used for evaluating corrective voltages and then reconverted to a non-rotating framework for application to the motor electrodes. Current-source drive circuits provide current stabilized outputs making such sophisticated control tractable.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: May 22, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Aditya N. Ghule, Baoyun Ge, Daniel Colin Ludois
  • Patent number: 9969686
    Abstract: Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: May 15, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Weiping Tang, Xiaoxun Li, Dongxu Shu, Gabrielle N. Winston-McPherson
  • Patent number: 9972687
    Abstract: Layers of high quality VO2 and methods of fabricating the layers of VO2 are provided. The layers are composed of a plurality of connected crystalline VO2 domains having the same crystal structure and the same epitaxial orientation.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: May 15, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Chang-Beom Eom, Daesu Lee
  • Patent number: 9968633
    Abstract: The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: May 15, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: May Pang Xiong, Zhi Liu, Yan Wang
  • Publication number: 20180127784
    Abstract: Methods of making synthetic yeast cells by mating together two diploid (or higher ploidy) yeast species or hybrids to generate multi-ploid yeast hybrids are provided herein. The synthetic yeast cells made by this process and kits for performing the process are also provided.
    Type: Application
    Filed: November 7, 2017
    Publication date: May 10, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: William Gerald ALEXANDER, David Peris NAVARRO, Christopher Todd HITTINGER