Patents Assigned to Wisconsin Alumni Research Foundation
  • Publication number: 20190012531
    Abstract: A monitoring system or tracking system may include an input port and a controller in communication with the input port. The input port may receive video from an image capturing device. The image capturing device is optionally part of the monitoring system and in some cases includes at least part of the controller. The controller may be configured to receive video via the input port and identify a subject within frames of the video relative to a background within the frames. Further, the controller may be configured to identify dimensions, posture, hand location, feet location, and/or other parameters of the identified subject in frames of the video and determine when the subject is performing a task. Based on the dimensions and/or other parameters identified or extracted from the video during the predetermined task, the controller may output via the output port assessment information.
    Type: Application
    Filed: July 18, 2018
    Publication date: January 10, 2019
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: ROBERT RADWIN, XUAN WANG, YU HEN HU, NICHOLAS DIFRANCO
  • Publication number: 20190012794
    Abstract: A monitoring system may include an input port, an output port, and a controller in communication with the input port and the output port. The input port may receive video from an image capturing device. The image capturing device is optionally part of the monitoring system and in some cases includes at least part of the controller. The controller may be configured to receive video via the input port and identify a subject within frames of the video relative to a background within the frames. Further, the controller may be configured to identify dimensions and/or other parameters of the identified subject in frames of the video and determine when the subject is performing a predetermined task. Based on the dimensions and/or other parameters identified or extracted from the video during the predetermined task, the controller may output via the output port assessment information.
    Type: Application
    Filed: October 6, 2017
    Publication date: January 10, 2019
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Robert RADWIN, Xuan WANG, Yu Hen HU, Nicholas DIFRANCO
  • Patent number: 10176991
    Abstract: High-quality, single-crystalline silicon-germanium (Si(1-x)Gex) having a high germanium content is provided. Layers of the high-quality, single-crystalline silicon-germanium can be grown to high sub-critical thicknesses and then released from their growth substrates to provide Si(1-x)Gex films without lattice mismatch-induced misfit dislocations or a mosaic distribution of crystallographic orientations.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: January 8, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Max G. Lagally, Thomas Francis Kuech, Yingxin Guan, Shelley A. Scott, Abhishek Bhat, Xiaorui Cui
  • Patent number: 10174008
    Abstract: Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. The method comprises contacting a reactant of formula I wherein E is a protecting group, —SO2-Aryl, or —SO2-substituted-Aryl; and R and R2 are independently selected from the group consisting of hydrogen, halo, C1-C12-alkyl and aryl; with a rhodium(1)-containing catalyst.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: January 8, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Weiping Tang, Xiaoxun Li
  • Patent number: 10172934
    Abstract: The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: January 8, 2019
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Yoshihiro Kawaoka, Gabriele Neumann, Jihui Ping
  • Patent number: 10171019
    Abstract: A controller includes a torque command value calculation module configured to calculate a torque command based on a speed command of the motor, an output voltage controlling module configured to control an output voltage of the power converter based on the torque command calculated by the torque command value calculation module, a voltage command value correcting module configured to correct a voltage command to the power converter based on a measured output voltage from the power converter, a flux estimation module configured to estimate stator flux and rotor flux of the motor in a subsequent control period based on the voltage command by the voltage command value correcting module and a measured current of the stator and a motor speed estimation module configured to estimate a speed of the motor in a subsequent control period based on the flux estimated by the flux estimation module.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 1, 2019
    Assignees: Toshiba Mitsubishi-Electric Industrial Systems Corporation, Wisconsin Alumni Research Foundation
    Inventors: Yang Xu, Ryo Iida, Robert D. Lorenz, Yukai Wang
  • Patent number: 10167516
    Abstract: Described herein are methods of predicting the risk of developing ovarian cancer recurrence of a subject comprising the steps of detecting the expression levels of at least four of the six genes selected from the group consisting of AKT2, KRAS, RAC1, CALM3, RPS6KA2 and YWHAB or the gene products thereof, wherein the presence of increased expression levels of the genes or the gene products is predictive of the increased risk of developing ovarian cancer recurrence in the subject. Kits for practicing the methods are also disclosed.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: January 1, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Christina Kendziorski Newton, Kevin Hasegawa Eng, Janet S. Rader, William H. Bradley
  • Patent number: 10170270
    Abstract: An ion source device for producing an ion beam may include a housing having an opening, a first electrode, and a second electrode. A portion of the first electrode and the second electrode may be located within the housing. The first electrode may have a first side facing the opening and may be configured to provide an electric field toward the opening. The second electrode may be configured to provide an electron presence between the first electrode and the opening at least at times when the first electrode is not providing the first electric field. The ion source device may include a magnet and may produce a magnetic field generally perpendicular to the electric field provided by the first electrode. The ion source device may provide an ion beam with low turn on delay, which may be on the order of one microsecond or less, and low turn on jitter.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: January 1, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventor: Andrew Seltzman
  • Patent number: 10166254
    Abstract: The present invention relates to methods for treating and preventing graft-versus-host disease (GVHD) and radiation-induced tissue damage or organ failure. More particularly, methods of the present invention comprise administering a therapeutically effective amount of mesenchymal stem cell-educated macrophages (MEMs) to a subject to treat or prevent GVHD, bone marrow failure, radiation-induced tissue damage or organ failure, or a condition associated with aberrant inflammation.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 1, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peiman Hematti, Myriam N. Bouchlaka, Christian M. Capitini
  • Publication number: 20180369487
    Abstract: A syringe adapter having a syringe holder and an actuator are disclosed. The syringe holder may include a fixed portion that may receive a barrel of a syringe and an adjustable portion adjustably positioned relative to the fixed portion, where the adjustable portion may receive a plunger of the syringe. To facilitate aspirating fluid to and/or dispensing fluid from the syringe, the actuator may be selectively actuated with one or more digits or a palm of a user's hand to adjust a position of the adjustable portion. The selective actuation of the actuator may be performed with one or more digits of the user while two or more other digits are engaging a portion of the adapter adjacent a dispensing end of the syringe. The adapter may include a gear system translating movement of the actuator to movement of the adjustable portion of the syringe holder.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 27, 2018
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: ROBERT RADWIN, JOSEPH ULBRICH, THOMAS YEN
  • Patent number: 10160968
    Abstract: Methods, kits, and compositions of matter suitable for use in RNA Tagging are disclosed. In one embodiment, a method includes: expressing a fusion protein within the cellular environment, the fusion protein including at least part of the protein of interest and a tagging domain, the tagging domain introducing a selective tag to an RNA to which the fusion protein selectively binds, the selective tag including a selective tag sequence or a selective covalent modification; allowing the tagging domain to tag the RNA to which the protein of interest selectively binds by waiting for about 1 minute to about 28 days; and identifying the tagged RNA.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: December 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Marvin P. Wickens, Christopher P. Lapointe, Melanie A. Preston
  • Patent number: 10162035
    Abstract: A system and method for generating magnetic resonance imaging (MRI) images is provided. The MRI system is directed to perform the dynamic contrast enhanced imaging study of the subject by exciting a two-dimensional (2D) slice within a portion of a field of view (FOV) of the MRI system and acquiring imaging data from the 2D slice by sampling k-space in a pseudorandom manner using sampling trajectories extending between a center of k-space and peripheral areas of k-space. Thereafter, the 2D slice is slid to another portion of the FOV at a velocity selected to be greater a velocity of the motion of the subject and the process is repeated for each of a plurality of 2D slices to create images of the subject where artifacts induced by the motion of the subject are reflected as geometric distortions.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: December 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Kevin M. Johnson
  • Patent number: 10160950
    Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: December 25, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Su-Chun Zhang, Zhongwei Du
  • Patent number: 10156901
    Abstract: A virtual touchscreen for mobile devices provides a touchscreen area displaced to a side of the display to eliminate problems of a finger blocking the display during normal touchscreen operation. The virtual touchscreen may be monitored by a sensor system looking edgewise from a housing of the mobile device employing as few as two displaced photodetectors and a correspondingly oriented light source constrained to sensitivity within a narrow fan-shaped light-sensing plane. Extraction of the spatial location of a finger touch within this touchscreen area may be performed by a model of reflected light signals of a finger in different locations calibrated to environmental parameters of finger reflectivity and background reflectivity by a simple calibration process.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 18, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Xinyu Zhang, Chi Zhang, Joshua Tabor, Jialiang Zhang
  • Publication number: 20180353465
    Abstract: Tannin-containing compositions and methods of using same to enhance or maintain immune function during simplified nutrition feeding. Pharmaceutical compositions, including enteral nutrition compositions, are provided. The compositions comprise such tannins as proanthocyanidins and/or hydrolysable tannins. Administering the tannins to the gastrointestinal tract of a subject receiving simplified nutrition, such as with enteral nutrition therapy or parenteral nutrition therapy, attenuates or prevents deleterious effects on the gastrointestinal immune system that would otherwise occur with the simplified nutrition.
    Type: Application
    Filed: August 14, 2018
    Publication date: December 13, 2018
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jess Dreher Reed, Dhanansayan Shanmuganayagam, Christian Gerald Krueger, Kenneth Allan Kudsk, Joseph Francis Pierre, Aaron F. Heneghan, Rodrigo P. Feliciano
  • Patent number: 10149472
    Abstract: Methods for stimulating the growth of non-leguminous plants are disclosed. In the methods, a non-leguminous plant, a part thereof, or a seedling or seed thereof is contacted with a composition comprising a chitooligosaccharide (CO) having the formula: R1 is —H, —CH3, —COCH3, —SO3H, —SO3Na, arabinose, methylated arabinose, fucose, or methylated fucose; R2 is —H, —CH3, —COCH3, —SO3H, —SO3Na, arabinose, methylated arabinose, fucose, or methylated fucose; each R3 is independently —H or —COCH3; and n is 0, 1, 2, 3, 4, 5 or 6. As non-limiting examples, the method can be used to stimulate production and yield in a cereal grain crop plant, such as rice, wheat or corn (maize).
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: December 11, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jean-Michel Ané, Audrey Kalil, Junko Maeda
  • Patent number: 10153146
    Abstract: The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (MS) at high mass accuracy (such as ?75 ppm or ?30 ppm) and the obtained mass spectra are matched with one or more prospective candidate molecules or chemical formulas. The invention provide, for example, methods and systems wherein the possible fragments that can be generated from the candidate molecules or chemical formulas are determined as well as the masses of each of these fragments. The invention provide, for example, methods and systems wherein the high-resolution mass spectra are then compared with the calculated fragment masses for each of the candidate molecules or chemical formula, and the portion of the high-resolution mass spectra that corresponds or can be explained by the calculated fragment masses is determined.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: December 11, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas W. Kwiecien, Derek J. Bailey, Michael S. Westphall, Joshua J. Coon
  • Patent number: 10152798
    Abstract: In accordance with some embodiments, systems, methods and media for determining object motion in three dimensions using speckle images are provided. In some embodiments, a system for three dimensional motion estimation is provided, comprising: a light source; an image sensor; and a hardware processor programmed to: cause the light source to emit light toward the scene; cause the image sensor to capture a first defocused speckle image of the scene at a first time and capture a second defocused speckle image of the scene at a second time; generate a first scaled version of the first defocused image; generate a second scaled version of the first defocused image; compare each of the first defocused image, the first scaled version, and the second scaled version to the second defocused image; and determine axial and lateral motion of the object based on the comparisons.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: December 11, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Mohit Gupta, Brandon M. Smith, Pratham H. Desai, Vishal R. Agarwal
  • Patent number: 10151741
    Abstract: An electrically conductive nanoscale pore may be employed as an antenna to provide precise localized measurements of the impedance-altering characteristics of a molecule such as DNA or RNA or the like passing through the pore. The use of radiofrequency measurements promises high-speed analysis of long molecules (polymers).
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: December 11, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Robert H. Blick, Abhishek Bhat, Paul Gwozdz
  • Publication number: 20180343890
    Abstract: The present invention concerns methods of isolating milk proteins. Methods of the invention include charged ultrafiltration processes that use variations in pH to further separate protein species.
    Type: Application
    Filed: August 3, 2018
    Publication date: December 6, 2018
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Mark R. ETZEL, Thatcher ROOT, Abhiram ARUNKUMAR, Seyhun GEMILI