Patents Assigned to Wittycell
  • Increase of immune response and targeting by antigens and/or drug linkage
    Patent number: 8642565
    Abstract: The present invention relates to compounds consisting of glycolipids covalently bound to an antigen or a drug via a linker. The said compounds are able to induce a stronger immune response than a composition comprising separated glycolipids and antigen. The said compounds are also able to target drug to CD1d restricted cells.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: February 4, 2014
    Assignee: Wittycell
    Inventor: Vincent Serra
  • Compositions for and methods of enhancing the immune response to antigens
    Patent number: 8211861
    Abstract: Compositions comprising the compound of formula are provided herein. Also provided are methods of enhancing an immune response of a subject to an antigen by administering the antigen and the composition. The enhanced immune response may be an humoral immune response, a CD4+ T cell response, a CD8+ T cell response or result in activation of antigen presenting cells. Methods of enhancing the immune response by intramuscular administration of an antigen and the composition including the compound of formula I are also provided.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: July 3, 2012
    Assignee: Wittycell
    Inventor: Vincent Serra
  • Compositions for and methods of enhancing the immune response to antigens
    Patent number: 8207135
    Abstract: Compositions comprising the compound of formula are provided herein. Also provided are methods of enhancing an immune response of a subject to an antigen by administering the antigen and the composition. The enhanced immune response may be an humoral immune response, a CD4+ T cell response, a CD8+ T cell response or result in activation of antigen presenting cells. Methods of enhancing the immune response by intramuscular administration of an antigen and the composition including the compound of formula I are also provided.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: June 26, 2012
    Assignee: Wittycell
    Inventor: Vincent Serra
  • COMPOSITIONS FOR AND METHODS OF ENHANCING THE IMMUNE RESPONSE TO ANTIGENS
    Publication number: 20100322952
    Abstract: Compositions comprising the compound of formula are provided herein. Also provided are methods of enhancing an immune response of a subject to an antigen by administering the antigen and the composition. The enhanced immune response may be an humoral immune response, a CD4+T cell response, a CD8+T cell response or result in activation of antigen presenting cells. Methods of enhancing the immune response by intramuscular administration of an antigen and the composition including the compound of formula I are also provided.
    Type: Application
    Filed: December 5, 2008
    Publication date: December 23, 2010
    Applicant: Wittycell
    Inventor: Vincent Serra
  • METHODS OF ENHANCING ADJUVATICITY OF VACCINE COMPOSITIONS
    Publication number: 20100285042
    Abstract: The immunogenicity of vaccines is enhanced by co-administering a synthetic glycolipid, designated PBS-57, with the vaccine. PBS-57 has the ability to stimulate both a cell-mediated and humoral immune response. Co-administration of PBS-57 with a vaccine may be used in methods to stimulate one or more of a humoral immune response, a CD4+ T cell response, and a CD8+ cytotoxic T cell response.
    Type: Application
    Filed: August 28, 2008
    Publication date: November 11, 2010
    Applicant: Wittycell
    Inventor: Vincent Serra