Abstract: An interchangeable chamber and barrel system for allowing an end user to easily change a chamber body and/or a barrel for a firearm without the assistance of a gunsmith. The interchangeable chamber and barrel system generally includes an interchangeable chamber body having a chamber that is removably connectable to a receiver of a firearm and an interchangeable barrel that is removably connected to the chamber body opposite of the receiver. The system also includes a sealing member positioned within channels in the barrel and the chamber body. The chamber body and/or the barrel may be changed on the firearm at any time based on the preference of the end user.