Patents Assigned to Worcester Foundation for Biomedical Research
  • Cancer treatment by expression of differentiation factor receptor
    Patent number: 6271205
    Abstract: Disclosed are methods of reducing or inhibiting the motility and/or proliferative abilities of a neural tumor cell, or of enhancing apoptosis or differentiation of the tumor cell, in which a vector comprising a nucleic acid encoding a cytoplasmic domain of a neurotrophin receptor tyrosine kinase, is transferred to the tumor cell such that the nucleic acid is expressed. The methods of the invention result in reduced tumorigenicity of neural tumors.
    Type: Grant
    Filed: March 12, 1997
    Date of Patent: August 7, 2001
    Assignees: University of Massachusetts Medical Center, Worcester Foundation for Biomedical Research
    Inventors: Alonzo H. Ross, Lawrence D. Recht, Mahesh B. Lachyankar
  • Conjugates of minor groove DNA binders with antisense oligonucleotides
    Patent number: 5955590
    Abstract: Compositions of antisense oligonucleotides conjugated to peptides of a plurality of N-methylpyrrolecarboxamides linked by peptide bonds is provided. The compositions form stable hybridization complexes with DNA and can be used for any purpose which involves hybridizing an oligonucleotide to a DNA molecule, such as in antisense procedures. A method for enhancing oligonucleotide binding to a target is also provided. The method involves the step of hybridizing the target DNA with an oligonucleotide-peptide composition.
    Type: Grant
    Filed: July 15, 1996
    Date of Patent: September 21, 1999
    Assignee: Worcester Foundation for Biomedical Research
    Inventors: Asya Levina, Paul C. Zamecnik
  • Methods of screening for compounds which modulate insect behavior
    Patent number: 5772983
    Abstract: Disclosed is a method of selecting for a compound which modulates the behavior of an insect. In this method, electrical characteristics of an insect chemoreceptor neuron in the presence of control stimulation, then a known chemical modulator of insect activity, and then a test compound are measured after the neuron is contacted therewith. These measurements are compared and the test compound classified based on this comparison.
    Type: Grant
    Filed: October 16, 1995
    Date of Patent: June 30, 1998
    Assignee: Worcester Foundation For Biomedical Research
    Inventors: Robert J. O'Connell, Alan J. Grant
  • Antiparasitic oligonucleotides active against drug resistant malaria
    Patent number: 5616564
    Abstract: The invention provides methods and materials for antisense oligonucleotide therapy against active pathogenic infection by drug resistant or drug sensitive pathogens, including Plasmodium falciparum.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: April 1, 1997
    Assignee: Worcester Foundation for Biomedical Research, Inc.
    Inventors: Eliezer Rapaport, Paul C. Zamecnik
  • Linear aminoalkylphosphoramidate oligonucleotide derivatives
    Patent number: 5563253
    Abstract: Disclosed are methods of producing a synthetic oligonucleotide of selected nucleotide sequence which is internally functionalized at at least one selected location with an aminoalkyl-phosphoramidate and labelled with a nonradioactive material. Also disclosed are oligonucleotides produced by this method.
    Type: Grant
    Filed: March 3, 1994
    Date of Patent: October 8, 1996
    Assignee: Worcester Foundation for Biomedical Research
    Inventors: Sudhir Agrawal, Jin-Yan Tang
  • Aminoalkylphosphotriester oligonucleotide derivatives
    Patent number: 5541306
    Abstract: Disclosed are methods of producing a synthetic oligonucleotide of selected nucleotide sequence which is internally functionalized at least one selected location with an aminoalkylphosphotriester, and labelled with a nonradioactive material. Also disclosed are oligonucleotides produced by this method.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: July 30, 1996
    Assignee: Worcester Foundation for Biomedical Research
    Inventors: Sudhir Agrawal, Jin-Yan Tang
  • Aminoalkylphosphorothioamidate oligonucleotide deratives
    Patent number: 5536821
    Abstract: Disclosed are methods of producing a synthetic oligonucleotide of selected nucleotide sequence which is internally functionalized at at least one selected location with an aminoalkylphosphorothioamidate and labelled with a nonradioactive material. Also disclosed are oligonucleotides produced by this method.
    Type: Grant
    Filed: December 16, 1994
    Date of Patent: July 16, 1996
    Assignee: Worcester Foundation for Biomedical Research
    Inventors: Sudhir Agrawal, Jin-Yan Tang