Abstract: The wound assessing method and system of the present teachings provide a convenient, quantitative mechanism for diabetic foot ulcer assessment.

Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.

Abstract: Systems and methods are described herein for determining the location of a transmitter by jointly and collectively processing the full sampled signal data from a plurality of receivers to form a single solution.

Abstract: The present disclosure provides a method and an apparatus for identifying development of diabetic cardiovascular autonomic neuropathy (DCAN) in a biological subject. In one aspect, the method includes collecting data associated with heart rates of a biological subject, and processing the collected data to extract primary and secondary components of the collected data by performing a principal dynamic mode (PDM) analysis. A significant reduction of the primary or secondary component at a predetermined time period can be indicative of the DCAN development.

Abstract: Enhanced real-time realizable AF algorithm for accurate detection of, and discrimination between, NSR, AF, PVC, and PAC. The method of these teachings includes an AF detection method having a modified Poincare approach in order to differentiate various patterns of PAC and PVC from NSR and AF. The method of these teachings can also apply to the Kullback-Leibler divergence or the Turning Point Ratio (TPR) to differentiate between various patterns of PAC and PVC from NSR and AF.

Abstract: The invention provides methods for rapid, continuous generation of cells and cell products using magnetically stabilized three-dimensional tissue culture. The invention also pertains to a continuous flow self-regulating closed system bioreactor system for magnetically stabilized three-dimensional tissue culture. The methods described here do not use traditional solid scaffolding for cell culture.

Abstract: Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., RGD-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells. Also provided are methods of making compositions that include fibrin microthreads. Also provided are methods for using the compositions to repair or ameliorate damaged or defective organs or tissues.

Abstract: An assessment engine includes a definition of inquiry skills being assessed. Assessment models are used to infer skill demonstration as one or more students engage in inquiry within computerized simulations and/or microworlds. A pedagogical agent and/or help system provides real-time feedback to one or more students based on the assessment model outputs, and/or based on additional models that track one or more students developing proficiency across inquiry tasks over time. A pedagogical agent and/or help system for science inquiry tutoring responds in real-time on the basis of knowledge-engineered and data-mined assessment and/or tracking models.

Abstract: Methods and systems for automatic detection of Atrial Fibrillation (AF) are disclosed. The methods and systems use time-varying coherence functions (TVCF) to detect AF. The TVCF is estimated by the multiplication of two time-varying transfer functions (TVTFs).

Abstract: A system and method for synchronizing the phases and frequencies of devices in multi-user, wireless communications systems are provided. A primary beacon signal is transmitted by a destination node in a wireless communications network to a plurality of source nodes. Secondary beacon signals are also exchanged between the source nodes. Using the primary and secondary beacon signals, the nodes generate local phase and frequency estimates which are used to control local phases and frequencies of the source nodes. The source nodes then transmit common information to the destination at carrier frequencies based on the estimated local frequencies and phases, so that the phases and frequencies of the transmitted information are synchronized to facilitate coherent combining of the bandpass signals at the destination. Phase and frequency synchronization can be applied to wireless communications systems having any number of source nodes, and effects of Doppler shifts and moving platforms are accounted for.

Abstract: A method for determining cardiac status comprises for a given patient, constructing a patient-specific, three-dimensional, computational model of the patient's heart; and executing the constructed computational model, said executing generating a quantitative analysis of cardiac function. A method of performing cardiac surgeries comprises: a) assessing surgical options based on a patient-specific, three-dimensional, computational model of a patient's heart; and b) performing surgery based on one or more of the surgical options.

Abstract: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.

Abstract: An apparatus comprising a crank-slider linkage and a rocker link. The crank-slider linkage has a crank coupled to the slider by a jointed connecting rod. The jointed connecting rod has a first link and a second link. The first link is coupled to the second link by a first revolute joint. The first link is coupled to the crank and has a longitudinal axis. The rocker link has a rocker end and a ground end. The rocker end is coupled to the jointed connecting rod. The ground end is coupled to ground by a second revolute joint. The rocker link and the second link are disposed on a common side of the longitudinal axis.

Abstract: In the method of these teachings for detection of physical phenomena from or analysis of physical signals, an improved Empirical Mode Decomposition method decomposes physical signals representative of a physical phenomenon into components.

Abstract: A method of making a membrane permeable to hydrogen gas (H2?) is disclosed. The membrane is made by forming a palladium layer, depositing a layer of copper on the palladium layer, and galvanically displacing a portion of the copper with palladium. The membrane has improved resistance to poisoning by H2S compared to a palladium membrane. The membrane also has increased permeance of hydrogen gas compared to palladium-copper alloys. The membrane can be annealed at a lower temperature for a shorter amount of time.

Abstract: The present invention is based on the discovery of a two- or three-organism model system that can be used to identify virulence factors involved in fungal infection and to screen for agents that attenuate the activity of those factors. The system includes a model eukaryote, the nematode, Caenorhabditis elegans, and one or more species of Candida, a fungal pathogen that infects humans, e.g., Candida albicans, C. dubliniensis, C. krusei, C. tropicalis, C. parapsilosis, or C. glabrata. The system also includes a food source for the C. elegans; the food source can be a live or attenuated bacterium, e.g., Escherichia coli.

Abstract: A system and method for synchronizing the phases and frequencies of devices in multi-user, wireless communications systems are provided. A primary beacon signal is transmitted by a destination node in a wireless communications network to a plurality of source nodes. Secondary beacon signals are also exchanged between the source nodes. Using the primary and secondary beacon signals, the nodes generate local phase and frequency estimates which are used to control local phases and frequencies of the source nodes. The source nodes then transmit common information to the destination at carrier frequencies based on the estimated local frequencies and phases, so that the phases and frequencies of the transmitted information are synchronized to facilitate coherent combining of the bandpass signals at the destination. Phase and frequency synchronization can be applied to wireless communications systems having any number of source nodes, and effects of Doppler shifts and moving platforms are accounted for.

Abstract: A self-governing fluidic variable inertia flywheel that can maintain a constant angular velocity is disclosed. The flywheel uses a movable member to separate a liquid filled chamber from a gas occupying chamber. In one embodiment, a self-governing fluidic variable inertia flywheel includes a container having an internal volume and a movable member disposed within the container such that the internal volume is separated into a first chamber and a second chamber containing a fluid. The movable member is responsive to changes in angular velocity of the fluid.

Abstract: A pulsed thermography defect detection apparatus including active and passive infrared (IR) thermography for non-destructive testing (NDT) of powdermetallic (P/M) components for on-line and off-line inspection.

Abstract: A computer system and method are disclosed for automatically generating a vascular model of a blood vessel to support, for example, identification of mechanical factors corresponding to the blood vessel. The method includes interpolating data points corresponding to a contour of the blood vessel; generating a structural model representing three-dimensional structural characteristics of the blood vessel based on interpolated contours; generating a fluid model representing three-dimensional characteristics of fluid flow within the vessel; and generating a vascular model based on the structural model and the fluid model. The method may also include performing a mechanical analysis of the vascular model to identify a mechanical factor associated with the vessel, for example, a factor associated with a potential plaque rupture within the vessel. Embodiments of the invention are applicable to the diagnosis, assessment, or treatment of cardiovascular diseases.