Abstract: An immunomodulatory protein is cloned from Ganoderma microsporum. Its molecular weight is 15863.79 Da. Its genome sequence and translated protein sequence are different from those protected by the known patent of glycoprotein LZ-8, which is isolated from the mycelium of G. lucidum and has immunomodulator effect, and its immunomodulator efficiency is better than that of LZ-8.