Abstract: A pickup cassette (10) for housing at least one pickup (90) to be utilized with stringed musical instruments (12), such as solid body electric guitars, is disclosed. The pickup cassette (10) may be removably secured in a cavity formed in the stringed musical instrument (12) beneath the strings by a retainer member (40) defining a track which engages a pair of runners (60) on the frame of the pickup cassette. Thus, a pickup cassette (10) designed for picking up a specific type of music, such as rock, may be removed and replaced by a different cassette designed for use when playing, for example, jazz. This arrangement permits the utilization of one musical instrument for playing a variety of types of music by simply removing and replacing any of several different pickup cassettes.