Patents Assigned to WOUNDCHEK LABORATORIES
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Publication number: 20200392557Abstract: Methods of detecting a local infection, critical colonization, or infection in a wound, predicting wound healing in a wound, and detecting bacterial pathogenesis in a wound are provided.Type: ApplicationFiled: August 31, 2020Publication date: December 17, 2020Applicant: Woundchek Laboratories (US), Inc.Inventors: Simon W. BAYLIFF, Patrick BROSNAN
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Patent number: 10774363Abstract: Methods of detecting a local infection, critical colonization, or infection in a wound, predicting wound healing in a wound, and detecting bacterial pathogenesis in a wound are provided.Type: GrantFiled: September 26, 2016Date of Patent: September 15, 2020Assignee: WOUNDCHEK LABORATORIES (US), INC.Inventors: Simon W. Bayliff, Patrick Brosnan
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Patent number: 9932622Abstract: Methods and devices for determining the healing status of wounds, in particular of chronic wounds are provided. Also provided are kits comprising the diagnostic devices, and methods of wound diagnosis and treatment using the diagnostic devices and methods. A diagnostic apparatus (device) for monitoring wounds that exude a wound fluid and determining whether said wounds would be responsive to treatment with wound therapy such as oxidized cellulose therapy is also provided along with kits comprising the diagnostic apparatus and a wound dressing. Furthermore, methods of prognosing and treating wounds that exude a wound fluid are also provided.Type: GrantFiled: January 31, 2012Date of Patent: April 3, 2018Assignee: Woundchek Laboratories B.V.Inventors: Simon William Bayliff, Breda Mary Cullen, Molly Gibson
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Patent number: 9435805Abstract: The present invention is directed to a method for the ultrasensitive detection of beta hemolytic Streptococcus, a bacterium implicated in strep throat, using a specific protease marker. Also disclosed is a device as well as a biosensor, both of which are useful for the detection of beta hemolytic Streptococcus. The biosensor and the device can be used in conjunction with other reagents as part of a kit for detecting strep throat.Type: GrantFiled: September 22, 2011Date of Patent: September 6, 2016Assignee: Woundchek Laboratories (US), Inc.Inventors: Mitchell C. Sanders, Dale Macy, Andrei Rakitin, Courtney Mankus
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Patent number: 9404931Abstract: The present invention relates to monitoring patients for an inflammatory condition or infection (preferably wound infection) by testing an extracellular fluid such as a wound fluid for an elevated level of: (i) vimentin; (ii) a vimentin breakdown product; or (iii) a marker indicative of the presence of vimentin. The present invention provides methods of diagnosis and prognosis, wound dressings, devices (e.g. biosensors) and kits for use in such methods.Type: GrantFiled: December 11, 2006Date of Patent: August 2, 2016Assignee: Woundchek Laboratories (US), Inc.Inventors: Faraia Shah, Rachael Clark, Patrick John Trotter, Paul William Watt, Breda Mary Cullen
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Patent number: 9315851Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ?1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: GrantFiled: December 18, 2014Date of Patent: April 19, 2016Assignee: Woundchek Laboratories (US), Inc.Inventors: Shite Sebastian, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Harvard, Mitchell C. Sanders
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Patent number: 9017963Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with an enzyme produced and/or secreted by the bacteria, and detecting modification or the absence of modification of the substrate, as an indicator of the presence or absence of the enzyme in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: GrantFiled: January 31, 2003Date of Patent: April 28, 2015Assignee: Woundchek Laboratories (US), Inc.Inventors: Mitchell C. Sanders, Adrian M. Lowe, Maureen A. Hamilton, Gerard J. Colpas
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Patent number: 8927204Abstract: Described herein is a substrate comprising at least one colorimetric component attached to a peptide, as well as methods for detecting a modification of said substrate. Also described are methods of detecting the presence or absence of a protein, for example, a protein produced by a microorganism, by contacting a substrate with a sample. If the sample contains the protein of interest, the substrate is modified and a visible color change results, indicating the presence or absence of the protein in the sample. The present invention also features biosensors and kits for detecting the presence or absence of microorganisms and/or proteins in a sample.Type: GrantFiled: November 3, 2004Date of Patent: January 6, 2015Assignee: WoundChek Laboratories, Inc.Inventors: Mitchell C. Sanders, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Havard
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Publication number: 20140322790Abstract: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the ?1-proteinase inhibitor. In the current invention, we have demonstrated that these peptide substrates without the alpha 1 protein can be efficiently used as peptide substrates. The modification or the absence of modification of this peptide substrate by the enzyme produced and/or secreted by the bacteria, can serve as an indicator for the presence or absence of the bacteria in the sample. The present invention also features a biosensor for detecting the presence or absence of bacteria in a sample.Type: ApplicationFiled: December 13, 2013Publication date: October 30, 2014Applicant: WOUNDCHEK LABORATORIESInventors: Shite Sebastian, Gerard J. Colpas, Diane L. Ellis-Busby, Jennifer M. Harvard, Mitchell C. Sanders