Abstract: An integrated on-line monitoring and thermostatic heating apparatus for a bioartificial liver device, the apparatus including a blood inlet, a blood pump, an arterial drip chamber, a bioreactor module, a venous drip chamber, and a blood reinfusion port which are connected in sequence. The bioreactor module includes a thermostatic water tank and a bioreactor disposed in the thermostatic water tank. The bioreactor includes a container, and a first partition and a second partition which are disposed in the container. The first partition and the second partition separate the container into three independent parts, that is, a plasma separator, an oxygenator, and a reactor. The plasma separator and the oxygenator are connected through an external connection pipe. The external connection pipe is equipped with a separation pump. The second partition includes a communication hole, and the reactor and the oxygenator are connected through the communication hole.

Abstract: A bioartificial liver device including a bioreaction chamber having a plurality of semi-permeable membranes and a plurality of filter spaces each confined by two adjacent semi-permeable membranes; a plurality of liver cell perfusion ports each communicating with one of the filter spaces for introducing the liver cells into the filter spaces, and a positive peristaltic pump. In the device, the semi-permeable membranes are disposed substantially horizontal with respect to the ground, and the positive peristaltic pump is adapted to drive the plasma flow from the bottom wall of the device to the top wall. The device of the invention improves the cell loading and the area for substance exchange between the blood and the liver cells.