Abstract: The present invention proposes a large industrial vacuum sealer system. The system comprises the following working steps: after materials are placed, a box base moves upwards to be jointed with a box cover in a sealing manner; the first valve 120 is switched on; a rotary vane pump starts roughly pumping the air; next, a roots pump starts working; when the pressure reaches a preset value, the first valve 120 is switched off; valves 110 and the second valve 130 are switched on; diffusion pumps start working; after the air is pumped out completely, all pumps stop working. A box body comprises the box cover and the box base, wherein the box body is fixedly mounted. The box base is driven by air cylinders to move along a rail. In the present invention, a light curtain sensor is mounted between the box cover and the box base.