Abstract: A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.
Type:
Application
Filed:
July 13, 2007
Publication date:
July 10, 2008
Applicant:
Wyeth, a Delaware corporation
Inventors:
Kathleen Young, David S. Howland, Karen L. Marquis, Sharon Rosenzweig-Lipson, Mark Ian Cockett