Patents Assigned to Wyeth Holdings
  • PRODUCTION OF THE LIPIDATED FORM OF THE PEPTIDOGLYCAN-ASSOCIATED LIPROPROTEINS OF GRAM-NEGATIVE BACTERIA
    Publication number: 20090060952
    Abstract: The expression of the lipidated form of the peptidoglycan-associated protein (PAL) of gram-negative bacteria is achieved through the use of a plasmid containing a tightly regulated promoter. A bacterial host cell is transformed, transduced or transfected with such a plasmid. The host cell is then cultured under conditions such that the lipidated recombinant PAL is expressed. The lipidated recombinant PAL is included in an antigenic composition administered to a mammalian host to immunize against a gram-negative bacterium.
    Type: Application
    Filed: October 20, 2008
    Publication date: March 5, 2009
    Applicant: Wyeth Holdings
    Inventor: Benjamin J. Metcalf
  • Tricyclic protein kinase inhibitors
    Patent number: 6608048
    Abstract: This invention provides compounds of Formula (I), where A″, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: August 19, 2003
    Assignee: Wyeth Holdings
    Inventors: Hwei-Ru Tsou, Elsebe Geraldine Overbeek-Klumpers, Allan Wissner