Patents Assigned to Wyeth LLC
  • Multivalent pneumococcal polysaccharide-protein conjugate composition
    Patent number: 8603484
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 3 polysaccharide covalently linked to a carrier protein, the method including periodic acid oxidation of the polysaccharide in the presence of bivalent cations.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: December 10, 2013
    Assignee: Wyeth LLC
    Inventor: A. Krishna Prasad
  • Method for producing storage stable viruses and immunogenic compositions thereof
    Patent number: 8603796
    Abstract: The invention relates to methods for producing storage stable virus compositions. In certain embodiments, the invention relates to one or more formulations and process steps which result in storage stable virus compositions, wherein the composition is storage stable as a lyophilized solid composition or a frozen liquid composition.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: December 10, 2013
    Assignee: Wyeth LLC
    Inventors: Jee Loon Look, Vladimir G. Frolov, Nandini Konar
  • Antibody-drug conjugates
    Patent number: 8586049
    Abstract: Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: November 19, 2013
    Assignee: Wyeth LLC
    Inventors: Hans-Peter Gerber, John Francis DiJoseph, Kiran Manohar Khandke, Kimberly Ann Marquette, Puja Sapra, Lioudmila Gennadievna Tchistiakova
  • Immunogenic compositions for the prevention and treatment of meningococcal disease
    Patent number: 8574597
    Abstract: The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: November 5, 2013
    Assignee: Wyeth LLC
    Inventor: Gary Warren Zlotnick
  • Triazine compounds as PI3 kinase and mTOR inhibitors
    Patent number: 8575159
    Abstract: Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: November 5, 2013
    Assignee: Wyeth LLC
    Inventors: Aranapakam Mudumbai Venkatesan, Zecheng Chen, Christoph Martin Dehnhardt, Osvaldo Dos Santos, Efren Guillermo Delos Santos, Arie Zask, Jeroen Cunera Verheijen, Joshua Aaron Kaplan, David James Richard, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Ariamala Gopalsamy, Kevin Joseph Curran, Mengxiao Shi
  • Immunogenic compositions of antigens
    Patent number: 8568735
    Abstract: The present invention relates to immunogenic compositions, comprising polypeptides and polysaccharides from Staphylococcus aureus. The present invention also relates to immunogenic compositions, comprising Staphylococcus aureus capsule polysaccharides conjugated to a carrier protein. In addition, the invention relates to methods of inducing an immune response in subjects against Staphylococcus aureus using immunogenic compositions of the Staphylococcus aureus polypeptides and capsule polysaccharides.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: October 29, 2013
    Assignee: Wyeth LLC
    Inventors: Annaliesa Anderson, Viliam Pavliak, Kathrin Ute Jansen, Ingrid Lea Scully, Steven Morris Baker, Jasdeep Singh Nanra, Ellen Murphy, Bruce Arthur Green, Mark Edward Ruppen, Yekaterina Timofeyeva
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20130281483
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof; useful as a peripheral mu opioid receptor antagonist.
    Type: Application
    Filed: November 9, 2012
    Publication date: October 24, 2013
    Applicant: Wyeth LLC
    Inventor: Wyeth LLC
  • Botanical butter stick lip balm
    Patent number: 8563048
    Abstract: A stick lip balm with efficacious amounts of natural moisturizer and organoleptic/sensory attributes of lip feel associated with moisturizers and emollients is provided. The lip balm of the invention comprises at least 90% botanically derived materials and can be formed into a stick sufficiently robust to substantially retain the stick shape under normal conditions of shipping, storage and usage. A method of making the stick lip balm is also provided.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: October 22, 2013
    Assignee: Wyeth LLC
    Inventors: Sara Vest Magee, John Oliver Bachert, Neil Partridge, Jay Roberts Dickerson
  • Formulations which stabilize and inhibit precipitation of immunogenic compositions
    Patent number: 8562999
    Abstract: The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: October 22, 2013
    Assignee: Wyeth LLC
    Inventors: Lakshmi Khandke, Ronald Malone, Cindy Xudong Yang, Hanyoung Han, Jee Loon Look, Zhaowei Jin, Robert C. Seid, Jr., Ying Chen
  • Compositions relating to a mutant toxin and methods thereof
    Patent number: 8557548
    Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: October 15, 2013
    Assignee: Wyeth LLC
    Inventors: Annaliesa Sybil Anderson, Robert G. K. Donald, Kathrin Ute Jansen, Michael James Flint
  • ANTI-NOTCH1 ANTIBODIES
    Publication number: 20130266594
    Abstract: The present invention provides for antibodies that bind to Notch1. The present disclosure also provides methods of making the antibodies, pharmaceutical compositions comprising these antibodies and methods of treating disorders with the antibodies and pharmaceutical compositions.
    Type: Application
    Filed: December 9, 2011
    Publication date: October 10, 2013
    Applicant: Wyeth LLC
    Inventors: Kenneth G. Geles, Bin-Bing Stephen Zhou, Lioudmila Gennadievna Tchistiakova, Yijie Gao, Joel Bard
  • Processes for the convergent synthesis of calicheamicin derivatives
    Patent number: 8546549
    Abstract: This invention describes processes for the convergent synthesis of calicheamicin derivatives, and similar analogs using bifunctional and trifunctional linker intermediates.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: October 1, 2013
    Assignee: Wyeth LLC
    Inventors: Keith Moran, Jianxin Gu
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8546418
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: October 1, 2013
    Assignees: Progenics Pharmaceuticals, Inc., Wyeth, LLC
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • CCI-779 FORMULATIONS FOR PARENTERAL ADMINISTRATION
    Publication number: 20130252998
    Abstract: This invention provides CCI-779 cosolvent concentrates which are useful in preparing a parenteral formulation of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) following admixture with a diluent.
    Type: Application
    Filed: May 13, 2013
    Publication date: September 26, 2013
    Applicant: Wyeth LLC
    Inventors: Joseph T. Rubino, Victoria Siskavich, Maureen M. Harrison, Pooja Gandhi
  • MICRONIZED TANAPROGET, COMPOSITIONS, AND METHODS OF PREPARING THE SAME
    Publication number: 20130251807
    Abstract: The present invention provides compositions, desirably pharmaceutical compositions, containing micronized tanaproget. The compositions can also contain microcrystalline cellulose, croscarmellose sodium, anhydrous lactose, magnesium stearate, micronized edetate calcium disodium hydrous, and micronized sodium thiosulfate pentahydrate. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.
    Type: Application
    Filed: May 9, 2013
    Publication date: September 26, 2013
    Applicant: Wyeth LLC
    Inventors: Arwinder S. Nagi, Ramarao Chatlapalli, Shamim Hasan, Mohamed Ghorab, Dhaval Gaglani
  • Process for producing aluminum phosphate
    Patent number: 8540955
    Abstract: The present invention provides improved methods for producing the aluminum adjuvant AlPO4. In one aspect, the present invention provides a method for producing aluminum phosphate which comprises the steps of mixing a solution of aluminum chloride and a solution of sodium phosphate tribasic to produce an aluminum phosphate precipitate, wherein the improvement comprises settling the aluminum phosphate precipitate at a temperature in the range of about 50° C. to about 70° C. In another aspect, the present invention is directed to methods for producing aluminum phosphate within a closed system.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: September 24, 2013
    Assignee: Wyeth LLC
    Inventors: Lakshmi Khandke, Joseph Perez
  • COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF
    Publication number: 20130244307
    Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
    Type: Application
    Filed: March 22, 2013
    Publication date: September 19, 2013
    Applicant: WYETH LLC
    Inventors: Annaliesa Sybil Anderson, Maninder K. Sidhu, Robert G. K. Donald, Kathrin Ute Jansen, Narender K. Kalyan, Terri L. Mininni, Justin Keith Moran, Mark E. Ruppen, Michael James Flint
  • Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
    Patent number: 8524281
    Abstract: The present invention provides an oral pharmaceutical formulation comprising coated spheroids of a kinase inhibitor such as neratinib, which formulation is designed to reduce or eliminate side effects associated with existing oral formulations of kinase inhibitors.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: September 3, 2013
    Assignee: Wyeth LLC
    Inventors: Sripriya Venkata Ramana Rao, Syed Muzafar Shah, Christopher Richard Diorio, Maja Vencl-Joncic, Eugene James Murphy
  • Oral formulations and lipophilic salts of methylnaltrexone
    Patent number: 8524276
    Abstract: The present invention provides compositions comprising methylnaltrexone or a salt thereof, and compositions and formulations thereof, for oral administration.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: September 3, 2013
    Assignee: Wyeth, LLC
    Inventors: Syed M. Shah, Christopher Richard Diorio, Eric C. Ehrnsperger, Xu Meng, Kadum A. Al Shareffi, Jonathan Marc Cohen
  • Coated tablet formulations and uses thereof
    Patent number: 8518446
    Abstract: The present invention provides coated tablet formulations comprising neratinib maleate, and improved methods for making such coated tablets.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: August 27, 2013
    Assignee: Wyeth LLC
    Inventors: Muhammad Ashraf, Mainuddin Mahmud, Chimanlall Goolcharran, Krishnendu Ghosh, Arwinder Singh Nagi