Patents Assigned to Wyeth LLC
  • IMMUNOTHERAPY REGIMES DEPENDENT ON APOE STATUS
    Publication number: 20100266505
    Abstract: The invention provides methods of immunotherapy of Alzheimer's and similar diseases in which the regime administered to a patient depends on the ApoE genotype of the patient.
    Type: Application
    Filed: October 17, 2008
    Publication date: October 21, 2010
    Applicants: Wyeth LLC, Janssen Alzheimer Immunotherapy
    Inventors: Ronald Black, Lars Ekman, Ivan Lieberburg, Michael Grundman, James Callaway, Keith M. Gregg, Jack Steven Jacobsen, Davinder Gill, Lioudmila Tchistiakova, Angela Widom
  • Serotonergic agents
    Patent number: 7816362
    Abstract: Novel piperazine derivatives are provided having the formula wherein R1 is cyano, nitro, trifluoromethyl or halogen, or pharmaceutically acceptable acid addition salts thereof, which are useful as 5-HT1A receptor antagonists.
    Type: Grant
    Filed: May 5, 2009
    Date of Patent: October 19, 2010
    Assignee: Wyeth LLC
    Inventors: Wayne Everett Childers, Michael Kelly, Sharon Joy Rosenzweig-Lipson
  • Methods of using antibodies against human IL-22
    Patent number: 7811567
    Abstract: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22) and methods of using those antibodies, for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: October 12, 2010
    Assignee: Wyeth LLC
    Inventors: Lynette A. Fouser, Martin Hegen, Deborah P. Luxenberg, Margot O'Toole
  • 9-substituted tetracyclines
    Patent number: 7812008
    Abstract: This invention provides compounds of Formula (I); or a tautomer or pharmaceutically acceptable salts thereof useful as antibacterial agents.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: October 12, 2010
    Assignee: Wyeth LLC
    Inventors: Phaik-Eng Sum, Tarek Mansour
  • Bicyclic 6-alkylidene-penems as ?-lactamase inhibitors
    Patent number: 7812014
    Abstract: The present invention provides a compound of formula I wherein one of A and B is hydrogen and the other an optionally substituted fused bicyclic heteroaryl group as defined herein; X is O; R5 is H, C1-C6 alkyl, C5-C6 cycloalkyl, or CHR3OCOC1-C6 alkyl; and R3 is hydrogen, C1-C6 alkyl, C5-C6 cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: October 12, 2010
    Assignee: Wyeth LLC
    Inventors: Aranapakam Mudumbai Venkatesan, Tarek Suhayl Mansour, Takao Abe, Itsuki Yamamura, Tsuyoshi Takasaki, Atul Agarwal, Osvaldo Dos Santos, Fuk-Wah Sum, Yang-I Lin
  • Methods and compositions for improving recombinant protein production
    Patent number: 7807804
    Abstract: Nucleic acid molecules modified to enhance recombinant protein, e.g., antibody, expression and/or reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing proteins devoid of mis-spliced and/or intron read-through by-products by the use of such vectors in host cells under cell culture conditions suitable for recombinant protein expression.
    Type: Grant
    Filed: October 5, 2005
    Date of Patent: October 5, 2010
    Assignee: Wyeth LLC
    Inventors: Martin S. Sinacore, Mark Leonard, Haley A. Laken, Jason Rouse
  • SYNTHESIS OF PYRROLIDINE COMPOUNDS
    Publication number: 20100249207
    Abstract: Provided are methods for the preparation of certain substituted pyrrolidine compounds, forms of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride, and methods for preparing and using these forms.
    Type: Application
    Filed: January 19, 2010
    Publication date: September 30, 2010
    Applicant: Wyeth LLC
    Inventors: Asaf R. Alimardanov, Lalitha Krishnan, Maotang Zhou, Ting-Zhong Wang, Jianxin Ren, John Leo Considine, Charles C. Wu, Jason Brazzillo, Panolil Raveendranath, Karen Sutherland, Mahmoud Mirmehrabi, Subodh S. Deshmukh, Girija Raveendranath, Vijay Raveendranath, Sanjay Raveendranath
  • FORMULATIONS FOR PARENTERAL DELIVERY OF COMPOUNDS AND USES THEREOF
    Publication number: 20100249169
    Abstract: The present invention provides formulations that achieve effective delivery of methylnaltrexone compositions. The provided formulations are useful for preventing, treating delaying, diminishing or reducing the severity of side effects resulting from use of analgesic opioids.
    Type: Application
    Filed: March 17, 2010
    Publication date: September 30, 2010
    Applicant: Wyeth LLC
    Inventors: Syed M. Shah, Christian Ofslager, Mahdi B. Fawzi, Nataliya Bazhina
  • Production of polyketides and other natural products
    Patent number: 7803808
    Abstract: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. Therefore in aspect the present invention provides 17-desmethylrapamycin and analogues thereof, methods for their production, including recombinant strains, and isolation and uses of the compounds of the invention. In a further aspect the present invention provides for the use of 17-desmethylrapamycin and analogues thereof in the induction or maintenance of immunosuppression, the stimulation of neuronal regeneration or the treatment of cancer, B-cell malignancies, fungal infections, transplantation rejection, graft vs. host disease, autoimmune disorders, diseases of inflammation vascular disease and fibrotic diseases, and in the regulation of wound healing.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: September 28, 2010
    Assignee: Wyeth LLC
    Inventors: Matthew Alan Gregory, Christine Janet Martin
  • Kv1.5 potassium channel inhibitors
    Patent number: 7803827
    Abstract: The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv1.5 potassium channel inhibitors, and to methods for treating cardiac arrhythmia.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: September 28, 2010
    Assignee: Wyeth LLC
    Inventors: John Michael Janusz, Stephen Joseph Hodson, Gregory Kent Bosch, Ronald Eugene White, Benjamin E. Blass, Christopher M. Jackson, Neil T. Fairweather
  • Substituted acetic acid derivatives
    Patent number: 7803835
    Abstract: The present invention relates generally to substituted acetic acid derivatives and methods of using them.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: September 28, 2010
    Assignee: Wyeth LLC
    Inventors: Ariamala Gopalsamy, Scott Lee Kincaid
  • Aminoalkylazole derivatives as histamine-3 antagonists
    Patent number: 7803825
    Abstract: The present invention provides a compound of formula Ia: and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: September 28, 2010
    Assignee: Wyeth LLC
    Inventors: Jonathan Laird Gross, Albert Jean Robichaud, Marla Jean Williams, Alessandro Mazzacani
  • Anilino-pyrimidine analogs
    Patent number: 7799915
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2, R3, R4, R5, and R6 are defined herein.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: September 21, 2010
    Assignee: Wyeth LLC
    Inventors: Fuk-Wah Sum, Dennis William Powell, Yixian Zhang, Lijing Chen, Scott Lee Kincaid, Lee Dalton Jennings, Yongbo Hu, Adam Matthew Gilbert, Matthew Gregory Bursavich
  • Fast dissolving tablet
    Patent number: 7799342
    Abstract: The present invention relates to processes for the preparation of tablets which dissolve rapidly in the mouth and provide an excellent mouthfeel. The tablets of the invention comprise a compound which melts at about 37° C. or lower, have a low hardness, high stability and generally comprise few insoluble disintegrants which may cause a gritty or chalky sensation in the mouth. Convenient and economically feasible processes by which the tablets of the invention may be produced are also provided.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: September 21, 2010
    Assignee: Wyeth LLC
    Inventors: Janos Szamosi, Kevin S. Kinter, Vincent H. Li, Khawla Abdullah Abu-Izza
  • Sulfonylated Heterocycles Useful for Modulation of the Progesterone Receptor
    Publication number: 20100234422
    Abstract: Compounds of the following structure are provided, wherein n, R1-R3 and R6-R9 are defined below, as are methods of preparing and using these compounds for contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms.
    Type: Application
    Filed: May 26, 2010
    Publication date: September 16, 2010
    Applicant: Wyeth LLC
    Inventors: Casey Cameron McComas, Andrew Fensome
  • Method of making heat cells comprising exothermic compositions having absorbent gelling material
    Patent number: 7794649
    Abstract: The present invention is directed to a method of making heat cells that are suitable for incorporation into disposable heating wraps. The heat cells comprise an exothermic composition comprising an absorbent gelling material, wherein the absorbent gelling material provides for improved heat application in the relief of temporary or chronic body aches and pains.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: September 14, 2010
    Assignee: Wyeth LLC
    Inventors: Vincent York-Leung Wong, Clarence Anthony Turley
  • GDF-9/BMP-15 modulators for the treatment of bone disorders
    Patent number: 7790161
    Abstract: The invention provides methods for treating or preventing bone degenerative disorders. The disorders treated or prevented include, for example, osteopenia, osteomalacia, osteoporosis, osteomyeloma, osteodystrophy, Paget's disease, osteogenesis imperfecta, and bone degenerative disorders associated with chronic renal disease, hyperparathyroidism, and long-term use of corticosteroids. The disclosed therapeutic methods include administering to a mammal an inhibitor of GDF-9 or BMP-15 in an amount effective to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) stimulate new bone formation; and/or (5) maintain bone mass and/or bone quality. The invention also provides methods for administering a GDF-9 agonist or a BMP-15 agonist to treat a bone disorder characterized by increased bone density or mass.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: September 7, 2010
    Assignee: Wyeth LLC
    Inventors: Emily Sheng-Ming Shen, Frederick J. Bex, Yogendra P. Kharode, Vargheese M. Chennathukuzhi, Murty V. Chengalvala, Ashok Bapat, Panayiotis E. Stevis, Gregory S. Kopf
  • Azinyl-3-sulfonylindazole derivatives as 5-hydroxytryptamine-6 ligands
    Patent number: 7790751
    Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: September 7, 2010
    Assignee: Wyeth LLC
    Inventors: Hassan Mahmoud Elokdah, Alexander Alexei Greenfield, Kevin Liu, Geraldine Ruth McFarlane, Cristina Grosanu, Jennifer Rebecca Lo, Albert Jean Robichaud
  • O-DESMETHYLVENLAFAXINE AND BAZEDOXIFENE COMBINATION PRODUCT AND USES THEREOF
    Publication number: 20100221445
    Abstract: A combination product containing at least two active compounds, O-desmethylvenlafaxine or a pharmaceutically acceptable salt thereof and bazedoxifene or a pharmaceutically acceptable salt thereof is described. Also described are methods of making and using this combination product to treat a variety of conditions associated with low circulating estrogen levels or low estrogen receptor activity.
    Type: Application
    Filed: April 30, 2010
    Publication date: September 2, 2010
    Applicant: Wyeth LLC
    Inventors: Syed M. Shah, Mahdi B. Fawzi, Christopher Richard Diorio
  • TREATMENT OF AMYLOIDOGENIC DISEASES
    Publication number: 20100221187
    Abstract: The invention provides preferred dosage ranges, maximum concentrations, average concentrations and monitoring regimes for use in treatment of Alzheimer's disease using antibodies to A?. The invention also provides monitoring regimes that can assess changes in symptoms or signs of the patient following treatment.
    Type: Application
    Filed: July 27, 2007
    Publication date: September 2, 2010
    Applicants: Janssen Alzheimer Immunotherapy, Wyeth LLC
    Inventors: Ivan Lieberburg, James Callaway, Michael Grundman