Patents Assigned to Wyeth, Madison, New Jersey
  • METHODS FOR ENHANCED PRODUCTION OF BONE MORPHOGENETIC PROTEINS
    Publication number: 20090317867
    Abstract: Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-? superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 ?M and if pyridoxal is present, it makes up less than 55% of the molar concentration of vitamin B6 in the media.
    Type: Application
    Filed: April 16, 2009
    Publication date: December 24, 2009
    Applicant: Wyeth, Madison, New Jersey
    Inventors: Yen-Tung Luan, Wenge Wang, Gregg Nyberg, Jose Manuel Gomes, Denis Drapeau, Terry Cardoza