Abstract: An apparatus and method for analyzing the morphometry of a human hip joint is provided. The apparatus includes image receiving means for receiving a digital image of a hip joint and image analysis means, including an Active Shape Model configured to identify a set of landmark points on the image, wherein the set of points includes points which correspond to features of the proximal femur and the region of the pelvis forming the acetabulum. The ASM is further configured to generate an image data-set from the co-ordinates of the landmark points; and data comparison means for comparing the image data-set with one or more comparative data-sets to obtain value(s) for one or more output modes which characterize the variation of the image data-set from the comparative data-set(s), to provide an indication of the presence and/or severity of osteoarthritis in the hip and/or the risk of the hip joint developing osteoarthritis.

Abstract: Apparatus and method for analyzing the morphometry of a human knee joint. The apparatus comprises: image receiving means for receiving a digital image of a knee joint; image analysis means comprising an Active Shape Model (ASM) configured to identify a set of landmark points on said image, wherein said set of landmark points includes points which define regions of the knee formed by the femur and the tibia, the ASM being further configured to generate an image data-set from the co-ordinates of said landmark points; and data comparison means for comparing said image data-set with one or more comparative data-sets to thereby obtain value(s) for one or more output modes which characterize the variation of the image data-set from the comparative data-set(s), to thereby provide an indication of the presence and/or severity of osteoarthritis in the knee and/or the risk of the knee joint developing osteoarthritis.

Abstract: The invention provides transgenic rodents, particularly mice, expressing truncated versions of the Disrupted-in-Schizophrenia-1 (DISC1) gene and showing Schizophrenia-related neural and behavioral phenotypes. The rodents of the invention have (1) a plurality of copies of a heterologous truncated Disc1 genomic DNA sequence which includes at least 1 stop codon after exon 8 such as to encode a Disc1 polypeptide truncated before exon 9; (2) 2 copies of endogenous Disc1 genomic DNA sequence encoding full length Disc1 polypeptide. Also provided are related materials and methods.

Abstract: The present invention relates to a hormonal contraceptive product having two hormonal components, an estrogen and a gestagen, and a method for the continuous suppression of the menstrual cycle by uninterrupted administration of the product of the invention.

Abstract: The present invention relates to a hormonal contraceptive product having two hormonal components, an estrogen and a gestagen, and a process for the combined, continuous administration of the product of the invention.