Patents Assigned to Wyeth
  • Cyclothiocarbamate derivatives as progesterone receptor modulators
    Patent number: 8466146
    Abstract: Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have the structure: wherein R1, R2, R3, R4, R5, and Q1 are defined herein.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: June 18, 2013
    Assignee: Wyeth LLC
    Inventors: Puwen Zhang, Andrew Fensome, Eugene A. Terefenko, Lin Zhi, Todd K. Jones, James P. Edwards, Christopher M. Tegley, Jay E. Wrobel, Mark A. Collins
  • CELL CULTURE OF GROWTH FACTOR-FREE ADAPTED CELLS
    Publication number: 20130150554
    Abstract: The present invention provides improved cell culture systems that allow optimum production of recombinant proteins. Among other things, the present invention provides methods of cell culture including a step of cultivating cells adapted to growth factor-free medium in a cell culture system that provides at least one growth factor.
    Type: Application
    Filed: August 8, 2011
    Publication date: June 13, 2013
    Applicant: WYETH LLC
    Inventors: Mark Wallace Melville, Tara Ann Chamberlain, Martin Sinacore
  • TANAPROGET DERIVATIVES, METABOLITES, AND USES THEREOF
    Publication number: 20130143827
    Abstract: A method of generating synthetic metabolites of tanaproget derivatives thereof is provided. These compounds and methods of using these derivatives for detecting tanaproget metabolites in samples are provided.
    Type: Application
    Filed: January 28, 2013
    Publication date: June 6, 2013
    Applicant: Wyeth LLC
    Inventor: Wyeth LLC
  • COMPOSITIONS CONTAINING MICRONIZED TANAPROGET PREPARED BY WET GRANULATION
    Publication number: 20130142838
    Abstract: Compositions, preferably pharmaceutical compositions, containing micronized tanaproget, or pharmaceutically acceptable salt thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, butylated hydroxyanisole, povidone, and magnesium stearate, are provided. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic to disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.
    Type: Application
    Filed: November 29, 2012
    Publication date: June 6, 2013
    Applicant: Wyeth LLC
    Inventor: Wyeth LLC
  • CCI-779 concentrate formulations
    Patent number: 8455539
    Abstract: This invention provides CCI-779 cosolvent concentrates which are useful in preparing a parenteral formulation of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) following admixture with a diluent.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: June 4, 2013
    Assignee: Wyeth LLC
    Inventors: Joseph T. Rubino, Victoria Siskavich, Maureen M. Harrison, Pooja Gandhi
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8455644
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: June 4, 2013
    Assignee: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • Micronized tanaproget, compositions, and methods of preparing the same
    Patent number: 8450312
    Abstract: The present invention provides compositions, desirably pharmaceutical compositions, containing micronized tanaproget. The compositions can also contain microcrystalline cellulose, croscarmellose sodium, anhydrous lactose, magnesium stearate, micronized edetate calcium disodium hydrous, and micronized sodium thiosulfate pentahydrate. The compositions are useful in contraception and hormone replacement therapy and in the treatment and/or prevention of uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, and carcinomas and adenocarcinomas of the pituitary, endometrium, kidney, ovary, breast, colon, and prostate and other hormone-dependent tumors, and in the preparation of medicaments useful therefor. Additional uses include stimulation of food intake.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: May 28, 2013
    Assignee: Wyeth LLC
    Inventors: Arwinder S. Nagi, Ramarao Chatlapalli, Shamim Hasan, Mohamed Ghorab, Dhaval Gaglani
  • Crystalline forms of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile and methods of preparing the same
    Patent number: 8445496
    Abstract: This invention is directed to a crystalline 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile monohydrate having an x-ray diffraction pattern wherein 2? angles (°) of significant peaks are at about: 9.19, 11.48, 14.32, 19.16, 19.45, 20.46, 21.29, 22.33, 23.96, 24.95, 25.29, 25.84, 26.55, 27.61, and 29.51, and a transition temperature of about 109° C. to about 115° C.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: May 21, 2013
    Assignee: Wyeth LLC
    Inventors: Marc Sadler Tesconi, Gregg Feigelson, Henry Strong, Hong Wen
  • Triazine compounds as PI3 kinase and mTOR inhibitors
    Patent number: 8445486
    Abstract: Compounds of formula I wherein: R1 is and R2, R4, and R6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: May 21, 2013
    Assignee: Wyeth LLC
    Inventors: Aranapakam Mudumbai Venkatesan, Zecheng Chen, Christoph Martin Dehnhardt, Osvaldo Dos Santos, Efren Guillermo Delos Santos, Arie Zask, Jeroen Cunera Verheijen, Joshua Aaron Kaplan, David James Richard, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Ariamala Gopalsamy, Kevin Joseph Curran, Mengxiao Shi
  • Immunogenic compositions of polypeptide antigens
    Patent number: 8445000
    Abstract: The present invention relates to immunogenic compositions, comprising polypeptides isolated from Staphylococcus epidermidis. The invention also relates to polynucleotides encoding Staphylococcus epidermidis polypeptides and their use in immunogenic compostions. In addition, the invention relates to methods of inducing an immune response in mammals against Staphylococcus epidermidis and Staphylococcus aureus using immunogenic compostions of the Staphylococcus epidermidis polypeptides and polynucleotides. The invention also relates to methods for detecting Staphylococcus epidermidis in a biological sample.
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: May 21, 2013
    Assignee: Wyeth LLC
    Inventors: Bret Richard Sellman, Steven Morris Baker
  • Methods of purifying anti A ? antibodies
    Patent number: 8440799
    Abstract: The present application provides methods of purifying A? binding proteins having a Fc region, for example, anti-A? antibodies or antibody fusions, by adsorbing the A? binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt buffer to remove impurities and subsequent recovery of the adsorbed A? binding protein. The present application also features methods of eluting the purified A? binding protein as well as the incorporation of the methods within a purification train. Kits comprising components for carrying out the methods and instructions for use are also provided.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: May 14, 2013
    Assignees: Janssen Alzheimer Immunotherapy, Wyeth LLC
    Inventors: Ranganathan Godavarti, Timothy Iskra
  • Burst Drug Release Compositions
    Publication number: 20130115250
    Abstract: Solid dose compositions comprising at least one low solubility pharmaceutically active ingredient, at least one low solubility filler and at least one controlled release agent. comprising at least one poorly soluble pharmaceutically active ingredient, a insoluble binder and at least one controlled release agent along with a method of manufacturing said composition are disclosed. Methods for making these compositions are also disclosed.
    Type: Application
    Filed: October 26, 2012
    Publication date: May 9, 2013
    Applicant: Wyeth LLC
    Inventor: Wyeth LLC
  • Burst Drug Release Compositions
    Publication number: 20130116327
    Abstract: A solid dose composition comprising at least one pharmaceutically active ingredient and at least one controlled release agent and method of manufacturing said composition is disclosed. The burst profile of at least one pharmaceutically active ingredient in the composition is regulated by the apparent viscosity of the controlled release agent and wherein at least one pharmaceutically active ingredient is processed by wet granulation.
    Type: Application
    Filed: October 26, 2012
    Publication date: May 9, 2013
    Applicant: Wyeth LLC
    Inventor: Wyeth LLC
  • Portable moist heat system
    Patent number: 8430921
    Abstract: A portable moist heat delivery system comprising a water vapor generating portion comprising a water vapor source and a heat source; a water vapor-air regulating portion, said water vapor-air regulating portion comprising a water vapor-air mixing layer, and a water vapor-air distribution layer; said water vapor generating portion and said water vapor-air regulating portion being in fluid communication; and said water vapor-air regulating portion having a latent heat delivery surface disposed adjacent said water vapor-air regulating portion which delivers moist heat at a preselected temperature range wherein about 15% to about 95% of the moist heat is latent heat of condensation. Methods include delivering improved pain relief, blood flow, relaxation, and reduced cardiac workload.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: April 30, 2013
    Assignee: Wyeth
    Inventors: Vincent York-Leung Wong, Marina Belkin, Chad Kamil Hickson, Leroy Glenn Owens, Jr.
  • Neutralizing antibodies against GDF-8 and uses therefor
    Patent number: 8420082
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.
    Type: Grant
    Filed: December 7, 2009
    Date of Patent: April 16, 2013
    Assignee: Wyeth LLC
    Inventors: Geertruida M. Veldman, Monique V. Davies, Kening Song, Neil M. Wolfman, Kristie Grove Bridges, Anne Field, Caroline Russell, Viia Valge-Archer
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8420663
    Abstract: The present invention provides a compound of formula I: wherein X?, R1, and R2 are as defined herein, and compositions thereof.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: April 16, 2013
    Assignee: Wyeth
    Inventors: Nataliya Bazhina, George Joseph Donato, III, Steven R. Fabian, John Lokhnauth, Sreenivasulu Megati, Charles K. Melucci, Christian Ofslager, Niketa Patel, Galen Radebaugh, Syed M. Shah, Jan Szeliga, Huyi Zhang, Tianmin Zhu
  • PET MONITORING OF A-BETA-DIRECTED IMMUNOTHERAPY
    Publication number: 20130084245
    Abstract: The present invention provides methods of monitoring A?-directed immunotherapy. The methods involve administering a PET ligand that binds to amyloid deposits and detecting the PET ligand in the brain to provide an indication of the level and/or distribution of amyloid deposits. Surprisingly, the data in the present application show that a statistically significant reduction in amyloid deposits occurs early and consistently among patients following initiation of treatment before statistically significant effects of most if not all other markers are detectable. In consequence, the present methods allow early detection of whether a patient is responding to the A?-directed immunotherapy and if necessary adjustment of the immunotherapy regime.
    Type: Application
    Filed: February 25, 2011
    Publication date: April 4, 2013
    Applicants: Wyeth LLC, Janssen Alzheimer Immunotherapy
    Inventors: Ronald Black, Michael Grundman
  • RATIONALLY DESIGNED MEDIA FOR CELL CULTURE
    Publication number: 20130084593
    Abstract: This invention relates to methods for rationally designing cell culture media for use in cell cultures, e.g., cell cultures employed in polypeptide production; cell culture media designed with the disclosed methods; methods of producing a polypeptide of interest, e.g., an antibody, using such media; polypeptides produced using the methods and media disclosed herein; and pharmaceuticals compositions containing such polypeptides. The rationally designed media contain a concentration of an amino acid that is calculated for use in cell mass, a concentration of the amino acid that is calculated for use in cell maintenance, and a concentration of the amino acid that is calculated for incorporation into the polypeptide of interest.
    Type: Application
    Filed: July 30, 2012
    Publication date: April 4, 2013
    Applicant: Wyeth LLC
    Inventors: Yen-Tung Luan, Wenge Wang, Ryan Nolan, Denis Drapeau
  • Method of delivering a skin benefit
    Patent number: 8409154
    Abstract: A method of providing a skin benefit to the skin including the use of a skin care active and a portable moist heat delivery system comprising: a water vapor generating portion comprising a water vapor source and a heat source; and a water vapor-air regulating portion located at a skin-facing side of the water vapor generating portion, the water vapor-air regulating portion comprising a water vapor-air mixing layer, a water vapor-air distribution layer, a latent heat delivery surface, and optionally a skin contact layer, where the water vapor generating portion and the water vapor-air regulating portion are in fluid communication is disclosed.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: April 2, 2013
    Assignee: Wyeth
    Inventors: Shekhar Mitra, Dean A. Zimmerman, Vincent York-Leung Wong, Marina Belkin
  • Heat pack insert
    Patent number: D679823
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: April 9, 2013
    Assignee: Wyeth LLC
    Inventors: Dean Jeffrey Daniels, Karin Michele Reed