Patents Assigned to Wyeth
  • LIVE ATTENUATED MYCOPLASMA STRAINS
    Publication number: 20120045476
    Abstract: The present invention provides live, attenuated Mycoplasma bacteria that exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type Mycoplasma bacterium of the same species. Also provided are vaccines and vaccination methods involving the use of the live, attenuated Mycoplasma bacteria, and methods for making live attenuated Mycoplasma bacteria.
    Type: Application
    Filed: October 28, 2011
    Publication date: February 23, 2012
    Applicant: Wyeth LLC
    Inventors: Mahesh KUMAR, Muhammad Ayub Khan
  • DESIGNER OSTEOGENIC PROTEINS
    Publication number: 20120046227
    Abstract: The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
    Type: Application
    Filed: August 17, 2011
    Publication date: February 23, 2012
    Applicant: WYETH LLC
    Inventors: Stephen Berasi, Robert Vincent Martinez, Michael John Cain, John Wozney, Howard Seeherman, Z. Sean Juo, Valerie Calabro, Christopher Todd Brown
  • Scent Ectoparasiticidal Formulation
    Publication number: 20120041042
    Abstract: The present invention provides an improved-scent composition comprising metaflumizone, as well as a method for protecting against ectoparasite infestations in a warm-blooded animal.
    Type: Application
    Filed: February 19, 2010
    Publication date: February 16, 2012
    Applicant: Wyeth LLC
    Inventors: Nahla Fattohi, Michael John Gliddon, Shobhan Shashikant Sabnis
  • Recombinant protective protein from
    Patent number: 8114417
    Abstract: The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight of about 20 kilo Daltons (kDa). The PPP exhibits the ability to reduce colonization of pneumococcal bacteria. Thus the present invention also pertains to compositions for the treatment and prophylaxis of infection or inflammation associated with bacterial infection.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: February 14, 2012
    Assignee: Wyeth LLC
    Inventors: Bruce A. Green, Amy W. Masi
  • Polymorph form II of tanaproget
    Patent number: 8114869
    Abstract: Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating or preventing uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, or carcinomas and adenocarcinomas comprising administering polymorph Form II to a mammalian subject.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: February 14, 2012
    Assignee: Wyeth LLC
    Inventors: Marc Sadler Tesconi, Mannching Sherry Ku, Yan Xu
  • Circovirus Sequences Associated With Piglet Weight Loss Disease (PWD)
    Publication number: 20120034630
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: October 20, 2011
    Publication date: February 9, 2012
    Applicant: WYETH LLC
    Inventors: André Jestin, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec
  • NOVEL IMMUNOGENIC COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCAL DISEASE
    Publication number: 20120034261
    Abstract: The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
    Type: Application
    Filed: March 20, 2009
    Publication date: February 9, 2012
    Applicant: Wyeth Holdings Corporation
    Inventors: Gary W. Zlotnick, Leah Diane Fletcher, John Erwin Farley, Liesel A. Bernfield, Robert J. Zagursky, Benjamin J. Metcalf
  • Processes for making hydrazides
    Patent number: 8110705
    Abstract: A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
    Type: Grant
    Filed: May 20, 2008
    Date of Patent: February 7, 2012
    Assignee: Wyeth LLC
    Inventors: George Anello Chiarello, Ayman Sahli
  • Nucleic acid and amino acid sequences relating to for diagnostics and therapeutics
    Patent number: 8110198
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: February 7, 2012
    Assignee: Wyeth LLC
    Inventors: Lynn A. Doucette-Stamm, David Bush
  • Membrane Evaporation for Generating Highly Concentrated Protein Therapeutics
    Publication number: 20120028878
    Abstract: The present invention relates to methods of generating highly concentrated protein solutions, e.g., an antibody solution, a therapeutic protein solution, etc. The methods of the invention include membrane evaporation, such as evaporation of protein-free solvent from the protein solution, which concentrates the protein. The methods of the present invention result in protein solution concentrations not previously achievable by conventional ultrafiltration methods, e.g., protein solution concentrations of greater than about 260 grams of protein per liter of solution.
    Type: Application
    Filed: March 24, 2010
    Publication date: February 2, 2012
    Applicant: Wyeth LLC
    Inventors: Glen Reed Bolton, Hari Acharya, Austin Wayne Boesch
  • THERMAL DEVICE
    Publication number: 20120022621
    Abstract: A method of delivering safe therapeutic heat to an unconscious or inert subject is described, wherein a disposable device is applied to the user that provides a consistent skin side temperature, wherein said device comprises a thermal source comprising a particulate exothermic composition; and a primary insulative material disposed on a skin side of the thermal source that delivers heat while protecting the subject from burns; wherein said device provides a rate of temperature change of less than about 0.8.
    Type: Application
    Filed: August 4, 2011
    Publication date: January 26, 2012
    Applicant: Wyeth LLC
    Inventors: Vincent York-Leung Wong, Mary Elaine Freeland, James Patrick Ebel
  • Immunogenic compositions for the prevention and treatment of meningococcal disease
    Patent number: 8101194
    Abstract: The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: January 24, 2012
    Assignee: Wyeth LLC
    Inventors: Gary W. Zlotnick, Leah Diane Fletcher, John Erwin Farley, Liesel A. Bernfield, Robert J. Zagursky, Benjamin J. Metcalf
  • 9-aminocarbonylsubstituted derivatives of glycylcyclines
    Patent number: 8101590
    Abstract: This invention provides compounds of Formula I having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II): where Q, R4, R5, R6 and R10 and A are defined in the specification are useful as chemical intermediates.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: January 24, 2012
    Assignee: Wyeth LLC
    Inventors: Phaik-Eng Sum, Tarek Suhayl Mansour, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini, Jaechul Shim
  • CYANOPYRROLE CONTAINING CYCLIC CARBAMATE AND THIOCARBAMATE BIARYLS AND METHODS FOR PREPARING THE SAME
    Publication number: 20120016118
    Abstract: Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided: Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 19, 2012
    Applicant: Wyeth LLC
    Inventor: Bogdan Kazimierz Wilk
  • MODIFIED SINGLE DOMAIN ANTIGEN BINDING MOLECULES AND USES THEREOF
    Publication number: 20120014975
    Abstract: The invention relates to modified single domain antigen binding molecules, e.g., SDAB molecules, in particular TNF?-binding SDAB molecules. Method of preparing, and using the modified single domain antigen binding molecules described herein, to treat, e.g., TNF?-associated disorders, are also disclosed.
    Type: Application
    Filed: July 14, 2011
    Publication date: January 19, 2012
    Applicant: Wyeth LLC
    Inventors: Martin Hegen, Stephane Hubert Olland, Yulia Vugmeyster, Xin Xu
  • ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS
    Publication number: 20120016106
    Abstract: The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
    Type: Application
    Filed: March 2, 2011
    Publication date: January 19, 2012
    Applicant: Wyeth LLC
    Inventors: Frank S. Walsh, Margaret M. Zaleska, David S. Howland, Erika L.F. Holzbaur-Howland, Lioudmila Tchistiakova, Riyez Karim, Pamela Kelley, William Kelley, Xiang-Yang Tan, Seung Poon Kwak, Karen Wallace, Nicholas Weber, Menelas N. Pangalos
  • CUT-POINT IN PTEN PROTEIN EXPRESSION THAT ACCURATELY IDENTIFIES TUMORS AND IS PREDICTIVE OF DRUG RESPONSE TO A PAN-ErbB INHIBITOR
    Publication number: 20120010240
    Abstract: A cut-point in the quantitative measurement of PTEN protein expression that accurately identifies tumors with two inactivated alleles of the PTEN gene. Patients with a normalized PTEN score of PTEN null will be treated with a pan-ErbB tyrosine kinase inhibitor. A normalized PTEN protein expression score is obtained by comparing the tumor PTEN OD expression value with the non-malignant PTEN OD expression value.
    Type: Application
    Filed: January 4, 2011
    Publication date: January 12, 2012
    Applicant: Wyeth LLC
    Inventors: Christina Marie Coughlin, Jay Marshall Feingold, Daniel Steven Johnston, Anna Berkenblit, Andrew Louis Strahs, Charles Michael Zacharchuk
  • NOVEL QUINOLINE ESTERS USEFUL FOR TREATING SKIN DISORDERS
    Publication number: 20120010205
    Abstract: Disclosed are quinoline esters of Formula (I): which are useful as Liver X receptors (LXR) modulators. Pharmaceutical compositions containing quinoline esters of Formula (I) and the use of quinoline esters of Formula (I) in the safe treatment of various skin disorders are also disclosed. Methods for preparing and using quinoline esters are further described.
    Type: Application
    Filed: July 7, 2011
    Publication date: January 12, 2012
    Applicant: Wyeth LLC
    Inventors: Ronald Charles Bernotas, Robert Singhaus, Sunil Nagpal, Catherine Thompson
  • Method of increasing trabecular bone density in a patient in need thereof by an antibody against GDF-8
    Patent number: 8092798
    Abstract: The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: January 10, 2012
    Assignee: Wyeth LLC
    Inventors: Jane Aghajanian, William J. Dunham, legal representative, Neil M. Wolfman, Denise O'Hara, Monique V. Davies, Geertruida M. Veldman, Kristie Grove Bridges, Lisa-Anne Whittemore, Tejvir S. Khurana, Mary L. Bouxsein
  • Circovirus Sequences Associated With Piglet Weight Loss Disease (PWD)
    Publication number: 20120005768
    Abstract: The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided. Method for selecting compounds capable of modulating the viral infection are further provided. Pharmaceutical, including vaccine, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.
    Type: Application
    Filed: September 6, 2011
    Publication date: January 5, 2012
    Applicant: WYETH LLC
    Inventors: André Jestin, Emmanuel Albina, Pierre Le Cann, Philippe Blanchard, Evelyne Hutet, Claire Arnauld, Catherine Truong, Dominique Mahe, Roland Cariolet, François Madec