Patents Assigned to Wyeth
  • METHODS FOR MODULATING BLADDER FUNCTION
    Publication number: 20090281091
    Abstract: This invention provides methods and pharmaceutical compositions for modulating bladder function, and in particular for maintaining bladder control or treating urinary incontinence.
    Type: Application
    Filed: June 5, 2009
    Publication date: November 12, 2009
    Applicant: Wyeth
    Inventor: William Jacobson
  • Mutants of the P4 protein of nontypable with reduced enzymatic activity
    Patent number: 7615229
    Abstract: A P4 variant protein that has reduced enzymatic activity and that induces antibody to wild-type P4 protein and/or has good bactericidal activity against non-typable H. influenzae (NTHi) is useful as an active component in an immunogenic composition for humans. Methods of using these proteins, and compositions containing them in combination with additional antigens, are also provided.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: November 10, 2009
    Assignees: Wyeth Holdings Corporation, The Curators of the University of Missouri
    Inventors: Bruce A. Green, Gary W. Zlotnick, Leah D. Fletcher, Arnold L. Smith, Thomas J. Reilly
  • Aggrecanase structure
    Patent number: 7615363
    Abstract: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: November 10, 2009
    Assignee: Wyeth
    Inventors: Lidia Mosyak, Thomas Saltmarsh Rush, III, Xiaotian Zhong, Thomas E. McDonagh, Katy E. Georgiadis, Phaik-Eng Sum, Edward R. LaVallie, Lisa A. Collins-Racie, Christopher John Corcoran, Ravindra Kumar, Tracy Hebert, Stephane Hubert Olland, Stewart Andrews Mackie
  • Antibodies against human interleukin-13 and pharmaceutical compositions thereof
    Patent number: 7615213
    Abstract: This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: November 10, 2009
    Assignee: Wyeth
    Inventors: Marion T. Kasaian, Lioudmila Tchistiakova, Geertruida M. Veldman, Kimberly Ann Marquette, Xiang-Yang Tan, Debra D. Donaldson, Laura Long Lin, Tania Shane, Amy Sze Pui Tam, Eric Feyfant, Nancy L. Wood, Lori J. Fitz, Angela M. Widom, Kevin D. Parris, Samuel J. Goldman, Jose W. Saldanha
  • PHARMACEUTICAL POLISH FORMULATIONS
    Publication number: 20090274757
    Abstract: Polish compositions for coating pharmaceutical solid dosage forms such as tablets are disclosed. The polish composition comprises water, coating agent, and a film forming agent. Polished pharmaceutical solid dosage forms such as tablets comprising a polished exterior surface are also disclosed. Processes of polishing pharmaceutical solid dosage forms such as tablets are disclosed.
    Type: Application
    Filed: April 30, 2009
    Publication date: November 5, 2009
    Applicant: WYETH
    Inventor: John C. CLARK
  • METHODS FOR TREATING INFLAMMATION
    Publication number: 20090274696
    Abstract: Provided are methods and compositions for reducing airway hyperresponsiveness and other inflammatory diseases, disorders and conditions in a mammal by decreasing FIZZ1 (Found in Inflammatory Zone 1) activity. Also provided are methods and compositions for identifying modulators of airway inflammation and/or inhibitors of FIZZ1. The present invention encompasses modulators of airway inflammation and/or inhibitors of FIZZ1 and uses thereof. In addition, the present invention provides methods and compositions for enhancing an immune response based on FIZZ1 protein.
    Type: Application
    Filed: April 29, 2009
    Publication date: November 5, 2009
    Applicant: WYETH
    Inventors: Hang Chen, Michael R. Bowman, Bruce A. Jacobson, Lawrence Mason
  • IL-13 BINDING AGENTS
    Publication number: 20090274705
    Abstract: Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
    Type: Application
    Filed: January 22, 2009
    Publication date: November 5, 2009
    Applicant: WYETH
    Inventors: Lioudmila Tchistiakova, Marion T. Kasaian, Debra D. Donaldson, Xiang-Yang Tan, Davinder Gill, Macy X. Jin, Bruce Jacobson, Samuel J. Goldman, John Knopf, Angela M. Widom
  • Adjuvant combination formulations
    Patent number: 7611721
    Abstract: The use of 3-O-deacylated monophosphoryl lipid A or monophosphoryl lipid A and derivatives and analogs thereof, in combination with a cytokine or lymphokine such as granulocyte macrophage colony stimulating factor or interleukin-12 is useful as an adjuvant combination in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: November 3, 2009
    Assignee: Wyeth Holdings Corporation
    Inventor: Michael Hagen
  • Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
    Patent number: 7612210
    Abstract: A process for the enantioselective synthesis of an (S)- or (R)-1-[2-dimethylamino)-1-(methoxyphenyl)ethyl]cyclohexanol and analogues or salt thereof are described.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: November 3, 2009
    Assignee: Wyeth
    Inventors: Paige Erin Mahaney, Madelene Miyoko Antane, Jerry Shunneng Sun
  • Methods for diagnosing RCC and other solid tumors
    Patent number: 7611839
    Abstract: Methods, systems and equipment for diagnosing renal cell carcinoma (RCC) and other solid tumors. This invention identifies numerous disease genes that are differentially expressed in the peripheral blood of patients having RCC or other solid tumors relative to disease-free humans. These disease genes can be used as surrogate markers for detecting the presence or absence of RCC or other solid tumors.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: November 3, 2009
    Assignee: Wyeth
    Inventors: Natalie C. Twine, Michael E. Burczynski, William L. Trepicchio, Andrew J. Dorner, Jennifer A. Stover, Donna K. Slonim
  • 2-Aryl- and 2-Heteroarylthiazolyl Compounds, Methods for Their Preparation and Use Thereof
    Publication number: 20090270363
    Abstract: The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin, including elevated securin levels.
    Type: Application
    Filed: March 27, 2009
    Publication date: October 29, 2009
    Applicant: Wyeth
    Inventors: Nan Zhang, Semiramis Ayral-Kaloustian, Tarek Suhayl Mansour, Thai Hiep Nguyen, Chuansheng Niu, Edward Christian Rosfjord, Ronald Suayan, Hwei-Ru Tsou
  • Crystal structure of human factor VIII and uses thereof
    Publication number: 20090271163
    Abstract: The present invention provides crystals of human Factor VIII, in particular, a B-domain deleted human Factor VIII, and its three-dimensional structure. The present invention also provides the structural information of Factor VIII, and methods for identifying compounds that modulate Factor VIII activity, for determining structures of Factor VIII homologs or analogs, and for designing drug candidates for the treatment of hemophilia based on the structural information.
    Type: Application
    Filed: December 5, 2008
    Publication date: October 29, 2009
    Applicant: Wyeth
    Inventors: Jacky Ngo, Mingdong Huang, David A. Roth, Barbara C. Furie, Bruce Furie
  • 2-Aryl-and 2-Heteroarylthiazolyl Compounds, Methods for Their Preparation and Use Thereof
    Publication number: 20090270447
    Abstract: The present invention discloses fused heterobicyclic 2-aryl- and 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumor growth in particular and to treat diseases or disorders associated with securin.
    Type: Application
    Filed: March 27, 2009
    Publication date: October 29, 2009
    Applicant: Wyeth
    Inventors: Nan Zhang, Semiramis Ayral-Kaloustian, Thai Hiep Nguyen, Chuansheng Niu, Edward Christian Rosfjord, Ronald Suayan
  • Substituted indolizines and derivatives as CNS agents
    Patent number: 7608626
    Abstract: Compounds of formula 1 or pharmaceutically acceptable salts thereof are provided: which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. The compounds, and compositions containing the compounds, can be used to treat a variety of central nervous system disorders such as schizophrenia.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: October 27, 2009
    Assignee: Wyeth
    Inventors: Annmarie Louise Sabb, Robert Lewis Vogel
  • Method and cloning vectors utilizing intergeneric conjugation for manipulation of actinomycetes biosynthesis genes
    Patent number: 7608448
    Abstract: The present invention relates to a vector comprising sequences that permit direct transfer of the vector from one prokaryotic cell to another, such as by intergeneric conjugation. The invention also relates to methods of making and using the vector.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: October 27, 2009
    Assignee: Wyeth
    Inventor: Nathan Magarvey
  • Formulations of hydrophobic proteins in an immunogenic composition having improved tolerability
    Patent number: 7608278
    Abstract: The present invention provides a method for producing a less-painful immunogenic composition of a hydrophobic protein in a pharmaceutically acceptable carrier suitable for administering to a mammal, comprising the steps of (a) solubilizing said hydrophobic protein with a zwitterionic detergent to make a first composition; (b) altering said first composition, such that the altered composition produces a reduction in pain as measured in the rat footpad model as compared to said first composition.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: October 27, 2009
    Assignee: Wyeth
    Inventors: Susan Kay Hoiseth, Thomas Newell Metcalf, III, Yury Vladimirovich Matsuka, Michael Hagen, Lakshmi Khandke
  • Sulfonyldihydroimidazopyridinone compounds as 5-hydroxytryptamine-6 ligands
    Patent number: 7608717
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
    Type: Grant
    Filed: September 19, 2007
    Date of Patent: October 27, 2009
    Assignee: Wyeth
    Inventors: Derek Cecil Cole, Ronald Charles Bernotas
  • Nucleic acid and amino acid sequences relating to for diagnostics and therapeutics
    Patent number: 7608450
    Abstract: The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting from bacterial infection.
    Type: Grant
    Filed: August 22, 2005
    Date of Patent: October 27, 2009
    Assignee: Wyeth
    Inventors: Lynn A. Doucette-Stamm, David Bush
  • SYNTHESIS OF PYRAZOLES
    Publication number: 20090264648
    Abstract: The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate ?7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.
    Type: Application
    Filed: January 14, 2009
    Publication date: October 22, 2009
    Applicants: WYETH, SIENA BIOTECH S.P.A.
    Inventors: Warren Chew, Zheng Wang, Gloria Cheal, Martial Bertrand, John Potoski, Mahmoud Mirmehrabi, Arianna Nencini, Riccardo Zanaletti
  • 3-Cyanoquinolines, Methods for Preparation and Use as Insulin-like Growth Factor Inhibitors
    Publication number: 20090264427
    Abstract: Imidazole-substituted 4-anilino-3-cyanoquinolines are described, which selectively inhibit IFGR kinase activity and are useful for treating disorders associated with IGFR kinases.
    Type: Application
    Filed: April 14, 2009
    Publication date: October 22, 2009
    Applicant: Wyeth
    Inventors: Scott Christian Mayer, Lori Michelle Miller