Patents Assigned to Wyeth
  • METHODS FOR PREVENTION AND TREATMENT OF CONDITIONS ARISING FROM LOCAL ESTROGEN DEFICIENCY
    Publication number: 20070238713
    Abstract: The present invention relates to methods for the prevention and treatment of conditions arising from local estrogen deficiency, such as dyspareunia, vulvar atrophy, vaginal atrophy, vaginal dryness, vulvar itching, vaginal itching, vulvar burning, vaginal burning, vulvar dystrophy, atrophic vaginitis or menopausal sexual dysfunction. In some embodiments, the methods include systemic, for example oral, administration of an estrogen, such as conjugated estrogens, and a progestagen, such as MPA, contemporaneously with local administration of an estrogen, for example conjugated estrogens. In some embodiments, the methods include the oral administration of conjugated estrogens and MPA, and the vulvar, vaginal, or vulvar and vaginal administration of conjugated estrogens, for example in a cream.
    Type: Application
    Filed: April 5, 2007
    Publication date: October 11, 2007
    Applicant: WYETH
    Inventors: Michael GAST, Eileen HELZNER
  • Anti-rapamycin monoclonal antibodies
    Patent number: 7279561
    Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monclonal antibody.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: October 9, 2007
    Assignee: Wyeth
    Inventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain
  • Rapamycin conjugates
    Patent number: 7279562
    Abstract: Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific for rapamycin or derivatives thereof. This invention also provides a rapamycin specific monoclonal antibody.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: October 9, 2007
    Assignee: Wyeth
    Inventors: Katherine L. Molnar-Kimber, Craig E. Caufield, Timothy D. Ocain
  • Hydroxy-biphenyl-carbaldehyde oxime derivatives and their use as estrogenic agents
    Patent number: 7279600
    Abstract: This invention provides estrogen receptor modulators having the structure: wherein R1 to R6 and R8 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: October 9, 2007
    Assignee: Wyeth
    Inventors: Richard Eric Mewshaw, Cuijian Yang
  • Methods and compositions for inhibiting the function of polynucleotide sequences
    Publication number: 20070232557
    Abstract: A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian cell an at least partially double-stranded RNA molecule comprising a polynucleotide sequence of at least about 200 nucleotides in length, said polynucleotide sequence being substantially homologous to a target polynucleotide sequence. This RNA molecule desirably does not produce a functional protein. The agents useful in the composition can be RNA molecules made by enzymatic synthetic methods or chemical synthetic methods in vitro; or made in recombinant cultures of microorganisms and isolated therefrom, or alternatively, can be capable of generating the desired RNA molecule in vivo after delivery to the mammalian cell.
    Type: Application
    Filed: December 14, 2006
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventors: Chandrasekhar Satishchandran, Catherine Pachuk
  • ANTI-5T4 ANTIBODIES AND USES THEREOF
    Publication number: 20070231333
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: March 9, 2007
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventors: Erwin BOGHAERT, Nitin Damle, Philip Hamann, Kiran Khandke, Arthur Kunz, Kimberly Marquette, Lioudmila Tchistiakova, Davinder Gill, Kodangattil Sreekumar
  • 4-substituted or unsubtituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid derivatives as beta-lactamase inhibitors
    Publication number: 20070232582
    Abstract: The present invention relates to novel, low molecular weight broad spectrum compounds in particular to a class of 4-substituted or unsubstituted-7-hydro-1,4-thiazepine-7-[bicyclic or tricyclic heteroaryl] substituted-3,6-dicarboxylic acid or their derivatives which have ?-lactamase inhibitory and antibacterial properties. The compounds are therefore useful in the treatment of antibacterial infections in humans or animals, either alone or in combination with other antibiotics.
    Type: Application
    Filed: May 25, 2007
    Publication date: October 4, 2007
    Applicant: Wyeth Holdings Corporation
    Inventors: Tarek Mansour, Aranapakam Venkatesan
  • West Nile vaccine
    Publication number: 20070231349
    Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
    Type: Application
    Filed: October 30, 2006
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventor: Hsien-Jue Chu
  • West Nile vaccine
    Publication number: 20070231350
    Abstract: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method for the prevention or amelioration of West Nile disease, such as encephalitis, in equidae by administering the vaccine composition herein set forth.
    Type: Application
    Filed: October 30, 2006
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventor: Hsien-Jue Chu
  • Multivalent pneumococcal polysaccharide-protein conjugate composition
    Publication number: 20070231340
    Abstract: An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. Also described is a method for making an immunogenic conjugate comprising Streptococcus pneumoniae serotype 3 polysaccharide covalently linked to a carrier protein, the method including periodic acid oxidation of the polysaccharide in the presence of bivalent cations.
    Type: Application
    Filed: December 22, 2006
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventors: William Hausdorff, George Siber, Peter Paradiso, A. Prasad
  • Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
    Publication number: 20070232618
    Abstract: The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
    Type: Application
    Filed: May 15, 2007
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventors: Ronald Bernotas, Yinfa Yan, Albert Robichaud, Guangcheng Liu
  • Thieno[3,2-b]pyridine-6-carbonitriles and thieno[2,3-b]pyridine-5-carbonitriles as protein kinase inhibitors
    Patent number: 7276519
    Abstract: This invention provides compounds of Formula (1a)–(1f), II wherein: X, m, n, q, R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, Q, Z, Z?, Z??, Z? and J are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
    Type: Grant
    Filed: May 14, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth
    Inventors: Diane Harris Boschelli, Nan Zhang, Ana Carolina Barrios Sosa, Haris Durutlic, Biqi Wu
  • Process for synthesizing beta-lactamase inhibitor intermediates
    Patent number: 7276611
    Abstract: There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are useful as intermediates in the preparation of ?-lactamase inhibitors.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Michael William Winkley, Anita Wai-Yin Chan, Ivo L. Jirkovsky, Kenneth Alfred Martin Kremer, Joseph Zeldis, Antonia Aristotelevna Nikitenko, Henry Lee Strong, Tarek Mansour, Gulnaz Khafizova, Aranapakam M. Venkatesan
  • Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
    Patent number: 7276603
    Abstract: Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: October 2, 2007
    Assignee: Wyeth
    Inventors: Aranapakam Mudumbai Venkatesan, Osvaldo Dos Santos, Magda Asselin, George Theodore Grosu, Deborah A. Evrard, Richard Eric Mewshaw, Kristin Meagher
  • Rapamycin analogues and uses thereof in the treatment of neurological disorders
    Patent number: 7276498
    Abstract: The present invention provides compounds of the following structure, wherein R1, R2, R4, R4?, R6, R7, and R15 are defined above: These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: October 2, 2007
    Assignee: Wyeth
    Inventors: Edmund Idris Graziani, Kevin Pong, Jerauld Skotnicki
  • Polynucleotide composition, method of preparation, and use thereof
    Patent number: 7276359
    Abstract: A lyophilized polynucleotide composition contains at least one polynucleotide and at least one cryoprotectant, wherein the ratio of the polynucleotide to cryoprotectant is from about 0.001 to about 1.0 part by weight polynucleotide per 1.0 part by weight of the cryoprotectant. This composition also contains from about 0.5 weight percent to about (6) weight percent water, based on the total weight of the final lyophilized polynucleotide composition. The polynucleotide composition of this invention is characterized by enhanced stability, in that it retains at least 90% supercoil over a time period of at least (10) days at a temperature of about 37° C. The lyophilized polynucleotide composition also has improved solubility. An improved process for lyophilization of polynucleotides employs a specific primary drying cycle, that results in the above-described stable, lyophilized polynucleotide composition.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: October 2, 2007
    Assignee: Wyeth
    Inventors: Shankar Musunuri, Patrick P. DeLuca
  • Treatment of pain
    Publication number: 20070225277
    Abstract: This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula I: or a pharmaceutically acceptable salt thereof, wherein each of R1, R2, R3, R4, R5, R6, n, and m is as defined and described herein. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of a compound of formula I.
    Type: Application
    Filed: March 23, 2007
    Publication date: September 27, 2007
    Applicant: Wyeth
    Inventor: Sharon Rosenzweig-Lipson
  • Novel HCV inhibitor combinations and methods
    Publication number: 20070224167
    Abstract: Novel hepatitis C virus (“HCV”) inhibitor combinations comprising an HCV protease inhibitor and HCV polymerase inhibitor, and optionally one or more biologically active agents, as well as uses of these combinations as HCV inhibitors and for treating hepatitis C and related disorders are disclosed.
    Type: Application
    Filed: February 9, 2007
    Publication date: September 27, 2007
    Applicants: Schering Corporation, ViroPharma Incorporated, Wyeth
    Inventors: Emillo Emini, Michael Flint, Anita Howe, Bruce Malcolm, Stanley Mullen, Robert Ralston, Xiao Tong
  • Methods for treating cognitive and other disorders
    Publication number: 20070225334
    Abstract: This invention provides methods and pharmaceutical compositions for treating cognitive disorders such as learning disorders, ADD/ADHD, and other disorders.
    Type: Application
    Filed: March 23, 2007
    Publication date: September 27, 2007
    Applicant: Wyeth
    Inventor: Sharon Rosenzweig-Lipson
  • METHODS FOR PREPARING O-DESMETHYLVENLAFAXINE
    Publication number: 20070225525
    Abstract: The present invention provides an efficient method of making O-desmethyl-venlafaxine.
    Type: Application
    Filed: June 1, 2007
    Publication date: September 27, 2007
    Applicant: Wyeth
    Inventor: Beat Weber