Abstract: The present invention provides isolated nucleic acids encoding full-length human estrogen receptor-&bgr; (hER&bgr;), which comprises 530 amino acids. The invention also provides isolated hER&bgr; polypeptides and hER&bgr;-reactive antibodies, including those that specifically recognize amino acids 1-45 of hER&bgr;. The invention also encompasses methods for identifying hER&bgr;-interactive compounds, including agonists, antagonists, and co-activators.
Type:
Application
Filed:
December 22, 2003
Publication date:
December 9, 2004
Applicant:
Wyett
Inventors:
Ramesh A. Bhat, Ruth Henderson, Chulai Hsiao, Sotirios K. Karathanasis