Patents Assigned to X-Body, Inc.
  • Patent number: 11814441
    Abstract: The present invention provides antigen-binding polypeptides, including bi-specific antigen-binding polypeptides, that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease, including cancer, are also encompassed by the invention.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: November 14, 2023
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Richard W. Wagner, Keming Zhang, Pascale Richalet
  • Patent number: 11629434
    Abstract: Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: April 18, 2023
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Tod M. Woolf, Richard W. Wagner
  • Patent number: 11414784
    Abstract: The invention provides methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: August 16, 2022
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Steven M. Shamah
  • Patent number: 11339388
    Abstract: Provided are methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell. Also provided are novel nucleic acid display libraries (e.g., DNA display libraries) useful in the methods of the invention.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: May 24, 2022
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Steven M. Shamah
  • Patent number: 11268090
    Abstract: The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: March 8, 2022
    Assignee: X-BODY, INC.
    Inventors: Richard W. Wagner, Alexander Litovchick, Yan Chen
  • Patent number: 11136398
    Abstract: The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen, e.g., human PDGFR?) with high affinity. The invention also provides, libraries of binding polypeptides, pharmaceutical compositions, as well as nucleic acids encoding binding polypeptides, recombinant expression vectors and host cells for making such binding polypeptides. Methods of using binding polypeptide of the invention to diagnose and treat disease are also encompassed by the invention.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: October 5, 2021
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Richard W. Wagner, Csaba Pazmany
  • Patent number: 11016100
    Abstract: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: May 25, 2021
    Assignee: X-BODY, INC.
    Inventors: Lance G. Laing, Rick Wagner, Rafael Fernandez, Alexander Yuzhakov
  • Patent number: 10677787
    Abstract: Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: June 9, 2020
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Tod M. Woolf, Richard W. Wagner
  • Patent number: 10604578
    Abstract: The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen, e.g., human PDGFR?) with high affinity. The invention also provides, libraries of binding polypeptides, pharmaceutical compositions, as well as nucleic acids encoding binding polypeptides, recombinant expression vectors and host cells for making such binding polypeptides. Methods of using binding polypeptide of the invention to diagnose and treat disease are also encompassed by the invention.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: March 31, 2020
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Richard W. Wagner, Csaba Pazmany
  • Patent number: 10519436
    Abstract: Provided are methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell. Also provided are novel nucleic acid display libraries (e.g., DNA display libraries) useful in the methods of the invention.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: December 31, 2019
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Steven M. Shamah
  • Patent number: 10519438
    Abstract: The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: December 31, 2019
    Assignee: X-BODY, INC.
    Inventors: Richard W. Wagner, Alexander Litovchick, Yan Chen
  • Patent number: 10370651
    Abstract: The invention provides methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: August 6, 2019
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Steven M. Shamah
  • Patent number: 10202462
    Abstract: The present invention provides antigen-binding polypeptides (e.g., bi-specific antigen-binding polypeptides) that specifically bind to a first and a second target antigen with high affinity. The present invention also provides novel antigen-binding polypeptides that specifically bind to HER2 and antagonize HER2 activation. The invention also provides nucleic acids encoding the antigen-binding polypeptides, recombinant expression vectors and host cells for making such antigen binding polypeptides. Methods of using antigen-binding polypeptide of the invention to treat disease (e.g., cancer) are also encompassed by the invention.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: February 12, 2019
    Assignee: X-BODY, Inc.
    Inventors: Yan Chen, Richard W. Wagner, Keming Zhang, Pascale Richalet
  • Patent number: 9880160
    Abstract: Provided are methods and compositions for the production of novel antibodies that bind specifically to a target antigen. These methods and compositions are particularly useful for producing antibodies having the antigen binding specificity of a reference antibody but with improved properties (e.g., binding affinity, immunogenicity, and thermodynamic stability) relative to the reference antibody.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: January 30, 2018
    Assignee: X-BODY, INC.
    Inventors: Yan Chen, Tod M. Woolf, Richard W. Wagner
  • Patent number: 9829435
    Abstract: A label-free biosensor detection arrangement incorporating an external cavity laser (ECL) includes a tunable lasing element (e.g. an antireflection coated laser diode or semiconductor optical amplifier) and a narrow bandwidth resonant reflectance filter as the wavelength-selective element for the tunable lasing element. A sample is deposited on the surface of the resonant reflectance filter containing a biological material. The wavelength emitted by the external cavity laser is continuously tunable by binding interactions between the biological material and the resonant reflectance filter or adsorption of the biological material present in the sample on resonant reflectance filter. The narrow bandwidth resonance reflectance filter can take the form of photonic crystal (PC), a Bragg stack, or a Brag fiber reflection filter.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: November 28, 2017
    Assignees: The Board of Trustees of the University of Illinois, X-Body, Inc.
    Inventors: Meng Lu, Chun Ge, Brian T. Cunningham, Stephen Schulz
  • Patent number: 9803193
    Abstract: The invention provides methods and compositions useful for identifying polypeptides with desired characteristics in vitro.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: October 31, 2017
    Assignee: X-BODY, INC.
    Inventors: Richard W. Wagner, Alexander Litovchick, Yan Chen
  • Patent number: 9778267
    Abstract: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: October 3, 2017
    Assignee: X-Body, Inc.
    Inventors: Brant Binder, Lance Laing
  • Patent number: 9416179
    Abstract: The present invention provides binding polypeptides (e.g., antibodies or fragments thereof) that specifically bind to a target antigen (e.g., a human antigen, e.g., human PDGFR?) with high affinity. The invention also provides, libraries of binding polypeptides, pharmaceutical compositions, as well as nucleic acids encoding binding polypeptides, recombinant expression vectors and host cells for making such binding polypeptides. Methods of using binding polypeptide of the invention to diagnose and treat disease are also encompassed by the invention.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: August 16, 2016
    Assignee: X-Body, Inc.
    Inventors: Yan Chen, Richard W. Wagner, Csaba Pazmany
  • Patent number: 9272126
    Abstract: Tubing such as clear plastic disposable tubing or glass tubing includes a photonic sensor formed in or placed within the tubing. The photonic sensors can take the form of photonic crystal sensors, distributed feedback laser sensors, and surface enhanced Raman spectroscopy (SERS) sensors, including photonic crystal enhanced SERS sensors. Detection arrangements for the sensors are described. The invention has many applications including tubing used in hospital care (e.g., urinary catheters, intravenous fluid delivery tubing, tubing used in dialysis, e.g. heparin lines or blood tubing sets), food manufacturing, pharmaceutical manufacturing, water quality monitoring, and environmental monitoring.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: March 1, 2016
    Assignees: The Board of Trustees of the University of Illinois, X-Body, Inc.
    Inventors: Brian T. Cunningham, Charles J. Choi, Alysia R. Watkins
  • Patent number: 9134307
    Abstract: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: September 15, 2015
    Assignee: X-Body, Inc.
    Inventors: Lance G. Laing, Rick Wagner, Rafael Fernandez, Alexander Yuzhakov