Patents Assigned to Xavier University
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Patent number: 11912660Abstract: The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer.Type: GrantFiled: April 16, 2021Date of Patent: February 27, 2024Assignee: Xavier University of LouisianaInventors: Jayalakshmi Sridhar, Melyssa Bratton, Rajesh Komati
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Patent number: 11708381Abstract: The present disclosure relates to androgen receptor signaling inhibitors and the synthesis of the same. Further, the present disclosure teaches the utilization of the androgen receptor signaling inhibitors in a treatment for proliferative diseases, including cancer, particularly prostate cancer, and especially castration-resistant prostate cancer.Type: GrantFiled: November 22, 2017Date of Patent: July 25, 2023Assignee: XAVIER UNIVERSITY OF LOUISIANAInventors: Guangdi Wang, Jiawang Liu, Shilong Zheng, Shanchun Guo
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Patent number: 11098053Abstract: Disclosed are daidzein analogs having the formula (I). Also disclosed are compositions, include a disclosed daidzein analogs, methods of preventing or treating bone disease or bone injury and/or stimulating bone growth, in a subject that include administering to the subject an effective amount of disclosed daidzein analog. Disclosed are isolated mesenchymal stem cell that has been altered by treatment a disclosed daidzein analog, daidzein, glycinol, glyceollin I, or glyceollin II, to increase the osteogenic potential of the mesenchymal stem cells.Type: GrantFiled: April 4, 2014Date of Patent: August 24, 2021Assignees: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, XAVIER UNIVERSITY OF LOUISIANA, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTUREInventors: Amy Strong, Stephen Boue, Matthew Burow, Bruce Bunnell, Quan Jiang, Shilong Zheng, Guangdi Wang
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Patent number: 11046715Abstract: The present disclosure relates to boronic derivatives of hydroxamate compounds, methods for making the same, methods for use as a monotherapy or in combination with one or more other therapeutic agents, for treatment of proliferative diseases such as cancer. The present disclosure also teaches the utilization of said boronic derivatives of hydroxamates as epigenetic therapy medications with enhanced bioavailability, lower-toxicity, and longer-lasting efficacy.Type: GrantFiled: November 27, 2017Date of Patent: June 29, 2021Assignee: Xavier University of LouisianaInventors: Guangdi Wang, Shilong Zheng, Jiawang Liu, Qiu Zhong, Shanchun Guo
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Patent number: 10203311Abstract: An emission monitoring system includes at least one gas analyzer for measuring a concentration of a first gas and a concentration of a second gas, a positioning system for determining the location of the at least one gas analyzer when the concentration of the first gas is measured. A method for monitoring emissions at an industrial site and a computer-implemented event detection system applies the steps of detecting the presence of a gas emission event based on a first detection ratio calculated from the measured concentration of the first gas, the measured concentration of the second gas, a background concentration of the first gas and a background concentration of the second gas.Type: GrantFiled: December 1, 2015Date of Patent: February 12, 2019Assignee: St. Francis Xavier UniversityInventors: David Andrew Risk, Bjorn-Gustaf James Brooks, Martin Lavoie
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Patent number: 10112962Abstract: Boron-based prodrugs of phenol- or aromatic hydroxyl group-containing therapeutic molecules (“original drugs”), uses thereof, and methods of making the same, are provided for achieving, for example, improved bioavailability, prolonged retention (e.g., in a circulatory system) and, in particular, significantly lowered therapeutically effective dosage in order to reduce adverse effects while maintaining the desired therapeutic effects of the original drugs.Type: GrantFiled: July 1, 2015Date of Patent: October 30, 2018Assignee: XAVIER UNIVERSITYInventors: Guangdi Wang, Qiu Zhong, Shilong Zheng
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Patent number: 10017475Abstract: Combretastatins analog compounds and their pharmaceutically acceptable salts are presented, as well as pharmaceutical compositions comprising the combretastatin analog compounds and uses of the combretastatin analog compounds, either alone or in combination with at least one additional therapeutic agent, in the treatment of cancer, and in particular cancer presenting as metastatic tumors.Type: GrantFiled: March 26, 2015Date of Patent: July 10, 2018Assignee: XAVIER UNIVERSITY OF LOUSIANAInventors: Guangdi Wang, Shilong Zheng, Qiu Zhong, Qiang Zhang
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Patent number: 9669004Abstract: Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer or tumor growth.Type: GrantFiled: January 15, 2015Date of Patent: June 6, 2017Assignees: The Administrators of the Tulane Educational Fund, United States Department of Agriculture, Xavier University of LouisianaInventors: Guangdi Wang, Matthew E. Burow, Stephen M. Boue, Thomas E. Wiese, Quan Jiang
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Patent number: 9650369Abstract: Thiazole analog compounds and their pharmaceutically acceptable salts are disclosed, including pharmaceutical compositions comprising the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, and/or with a pharmaceutically acceptable carrier. Methods of using the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative diseases, such as cancer, are also disclosed.Type: GrantFiled: September 27, 2013Date of Patent: May 16, 2017Assignee: XAVIER UNIVERSITY OF LOUISIANAInventors: Guangdi Wang, Quan Jiang, Qiu Zhong, Qiang Zhang, Shilong Zheng
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Patent number: 9636299Abstract: Compositions useful for treatment of retinal pathologies, including diabetic retinopathy, and methods of making and using said compositions, are provided.Type: GrantFiled: March 15, 2013Date of Patent: May 2, 2017Assignee: XAVIER UNIVERSITY OF LOUISIANAInventor: Partha S. Bhattacharjee
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Patent number: 9353132Abstract: The present disclosure relates to boron-based 4-hydroxytamoxifen and endoxifen prodrugs and the synthesis of the same. Further, the present disclosure teaches the utilization of the boron-based 4-hydroxytamoxifen and endoxifen prodrugs in a treatment for breast cancer.Type: GrantFiled: March 5, 2013Date of Patent: May 31, 2016Assignee: XAVIER UNIVERSITY OF LOUISIANAInventors: Guangdi Wang, Shilong Zheng, Quan Jiang, Qiu Zhong, Qiang Zhang
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Patent number: 8962679Abstract: Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer or tumor growth.Type: GrantFiled: July 8, 2011Date of Patent: February 24, 2015Assignees: The Administrators of the Tulane Educational Fund, Xavier University of LouisianaInventors: Guangdi Wang, Matthew E. Burow, Stephen M. Boue, Thomas E. Wiese, Quan Jiang
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Publication number: 20150045296Abstract: Compositions useful for treatment of retinal pathologies, including diabetic retinopathy, and methods of making and using said compositions, are provided.Type: ApplicationFiled: March 15, 2013Publication date: February 12, 2015Applicant: XAVIER UNIVERSITY OF LOUISIANAInventor: Partha S. Bhattacharjee
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Patent number: 8912359Abstract: A method of combating infectious agents, such as Pneumocystis pneumonia, and a method of treating a subject in need of such treatment is disclosed. The method comprises administering to the subject a bis-benzamidoxime of formula I wherein the linker is a di-substituted cyclic moiety of any ring size and may contain at least one heteroatom; the aromatic group is 1,2-; 1,3-; or 1,4-disubstituted; R is selected from the group consisting of a hydrogen, a linear or branched alkyl group, containing from 1 to 20 carbon atoms; R? is selected from the group consisting of a hydrogen, a linear or branched alkyl group containing from one to twenty carbon atoms, an aromatic ring, a cycloalkyl group containing three to eight carbon atoms, or a hydroxyl group; alternatively, R and R? may form a cyclic structure that can be fused to another cyclic system; or a pharmaceutically acceptable salt thereof. Pharmaceutical formulations and active compounds useful in the practice of the present invention are also disclosed.Type: GrantFiled: March 17, 2011Date of Patent: December 16, 2014Assignees: University of Cincinnati, Xavier UniversityInventors: Peter D. Walzer, Melanie T. Cushion, Annie Mayence, Tien Liang Huang, Jean Jacques Vanden Eynde
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Patent number: 8712692Abstract: A method for determining a flux of a gas contained in a medium through a boundary of the medium comprises 1) measuring at least twice with a probe a concentration C of the gas over a time interval ?t and 2) determining the flux of the gas using the following mathematical equation: (I) where F is the gas flux, D is the diffusivity value and ?C is a variation in the gas concentration during the time interval ?t. The probe is placed proximate the boundary. The probe has a gas inlet, a cavity, a gas concentration sensor and a membrane. Each element is in fluid communication with each other so that the gas flows from the gas inlet through the membrane and contacts the gas concentration sensor.Type: GrantFiled: December 15, 2008Date of Patent: April 29, 2014Assignee: St. Francis Xavier UniversityInventors: David A. Risk, Hugo J. Beltrami, Nicholas R. Nickerson, Gordon McArthur
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Patent number: 8681336Abstract: A method and system comprising measuring concentrations of first and second isotopologues of a gas of interest within a first cavity that is sealably in contact with a soil location through an inlet membrane, and the first cavity being defined by chamber walls having openings covered by outlet membranes. Reference concentrations of the first and second isotopologues are measured in a second cavity having a closed bottom, the second cavity being defined by chamber walls having openings covered by more outlet membranes. Relative flux of the isotopologues can be calculated using the measured concentrations.Type: GrantFiled: March 12, 2012Date of Patent: March 25, 2014Assignee: St. Francis Xavier UniversityInventors: Nicholas R. Nickerson, Jocelyn Elizabeth Egan, David Andrew Risk
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Patent number: 8628701Abstract: A method of preparing micro-capsules. The active ingredient, preferably provided in the form of an acid salt dissolved in a basic aqueous solution, is emulsified into a polymer solution, preferably PLGA in a relatively volatile solvent such as dichloromethane, to create a water in oil emulsion. This emulsion is further emulsified into an aqueous solution having a pH of a between about 7.4 and 8.0 and most preferably between about 7.8 and 8.0 to create a water in oil in water solution. The polymer solvent is allowed to evaporate, causing the emulsified active ingredient and surrounding polymer matrix to precipitate, thereby forming the micro-capsules. The micro-capsules are separated from the suspension, washed and freeze dried. The method has a very high encapsulation efficiency, even at high loading rates. Additionally, the dissolution rate of the micro-particles produced by the method is very steady over a long period of time.Type: GrantFiled: October 31, 2006Date of Patent: January 14, 2014Assignee: Xavier University of LouisianaInventors: Tarun K. Mandal, Richard Graves
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Patent number: 8563599Abstract: Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are also synthesized and claimed for their novel compositions of matter. All compounds and their mixtures are claimed for use in formulations that are useful to treat or prevent cancer, or that have utility as selective estrogen receptor modulators, such formulations including enhanced or medical foods, dietary supplements and ethical pharmaceutical agents.Type: GrantFiled: March 3, 2009Date of Patent: October 22, 2013Assignees: The United States of America, represented by the Secretary of Agriculture, Xavier University of Louisiana, University of ToledoInventors: Paul W. Erhardt, Rahul Khupse, Jefferey G. Sarver, Thomas E. Cleveland, Stephen M. Boue, Thomas E. Wiese, Matthew E. Burow, John A. McLachlan
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Publication number: 20130235378Abstract: A method and system comprising measuring concentrations of first and second isotopologues of a gas of interest within a first cavity that is sealably in contact with a soil location through an inlet membrane, and the first cavity being defined by chamber walls having openings covered by outlet membranes. Reference concentrations of the first and second isotopologues are measured in a second cavity having a closed bottom, the second cavity being defined by chamber walls having openings covered by more outlet membranes. Relative flux of the isotopologues can be calculated using the measured concentrations.Type: ApplicationFiled: March 12, 2012Publication date: September 12, 2013Applicant: St. Francis Xavier UniversityInventors: Nicholas R. Nickerson, Jocelyn Elizabeth Egan, David Andrew Risk
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Publication number: 20130184475Abstract: Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer or tumor growth.Type: ApplicationFiled: July 8, 2011Publication date: July 18, 2013Applicants: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, XAVIER UNIVERSITY OF LOUISIANNA, UNITED STATES DEPARTMENT OF AGRICULTUREInventors: Guangdi Wang, Matthew E. Burow, Stephen M. Boue, Thomas E. Wiese, Quan Jiang