Patents Assigned to Xcovery Holdings Company, LLC
  • Substituted pyridazinecarboxamides as kinase inhibitors
    Patent number: 9296724
    Abstract: Pyridazine derivatives (e.g., Formula I) have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: March 29, 2016
    Assignee: Xcovery Holding Company LLC
    Inventors: Congxin Liang, Zhigang Li
  • Substituted pyridazine carboxamide compounds as kinase inhibitor compounds
    Patent number: 9242958
    Abstract: The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against c-Met and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: January 26, 2016
    Assignee: Xcovery Holding Company LLC
    Inventor: Congxin Liang
  • Substituted pyridazine carboxamide compounds
    Patent number: 9126947
    Abstract: The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against ALK and are useful in treating disorders related to abnormal protein kinase activities such as cancer, neurological and psychiatric diseases.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: September 8, 2015
    Assignee: Xcovery Holding Company LLC
    Inventor: Congxin Liang
  • mTOR selective kinase inhibitors
    Patent number: 8912178
    Abstract: The 4-urea-phenyl substituted 6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine derivatives are potent and selective inhibitors of mTOR kinase and are useful in treating disorders related to abnormal mTOR activities such as cancer, immune disorders, cardiovascular disease, ocular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: December 16, 2014
    Assignee: Xcovery Holdings Company, LLC
    Inventor: Congxin Liang
  • SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS
    Publication number: 20140221376
    Abstract: Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: April 9, 2014
    Publication date: August 7, 2014
    Applicant: Xcovery Holding Company, LLC
    Inventors: Congxin Liang, Zhigang Li
  • Substituted pyridazine carboxamide compounds as kinase inhibitor compounds
    Patent number: 8697866
    Abstract: Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: April 15, 2014
    Assignee: Xcovery Holding Company LLC
    Inventors: Congxin Liang, Zhigang Li
  • PI3K (delta) SELECTIVE INHIBITORS
    Publication number: 20140051699
    Abstract: Novel PI3K, especially PI3K delta isoform, selective inhibitors are disclosed. The compounds are useful in treating disorders related to abnormal PI3K or PI3K? activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
    Type: Application
    Filed: October 28, 2013
    Publication date: February 20, 2014
    Applicant: Xcovery Holding Company, LLC
    Inventor: Congxin Liang
  • PI3K/mTOR kinase inhibitors
    Patent number: 8586582
    Abstract: 6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mT0R activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: November 19, 2013
    Assignee: Xcovery Holding Company, LLC
    Inventors: Congxin Liang, Zhigang Li
  • PI3K (delta) selective inhibitors
    Patent number: 8569296
    Abstract: Novel PI3K, especially PI3K delta isoform, selective inhibitors are disclosed. The compounds are useful in treating disorders related to abnormal PI3K or PI3K? activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: October 29, 2013
    Assignee: Xcovery Holding Company, LLC
    Inventor: Congxin Liang
  • Kinase inhibitor compounds
    Patent number: 8551995
    Abstract: Pyridine and pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: October 8, 2013
    Assignee: Xcovery Holding Company, LLC
    Inventor: Congxin Liang
  • SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS
    Publication number: 20130203763
    Abstract: The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against c-Met and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
    Type: Application
    Filed: October 7, 2011
    Publication date: August 8, 2013
    Applicant: Xcovery Holding Company, LLC
    Inventor: Congxin Liang
  • SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS
    Publication number: 20130190298
    Abstract: The new pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases especially against ALK and are useful in treating disorders related to abnormal protein kinase activities such as cancer, neurological and psychiatric diseases.
    Type: Application
    Filed: October 7, 2011
    Publication date: July 25, 2013
    Applicant: Xcovery Holding Company, LLC.
    Inventor: Congxin Liang
  • mTOR SELECTIVE KINASE INHIBITORS
    Publication number: 20130072481
    Abstract: The 4-urea-phenyl substituted 6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine derivatives are potent and selective inhibitors of mTOR kinase and are useful in treating disorders related to abnormal mTOR activities such as cancer, immune disorders, cardiovascular disease, ocular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
    Type: Application
    Filed: May 18, 2011
    Publication date: March 21, 2013
    Applicant: XCOVERY HOLDING COMPANY, LLC
    Inventor: Congxin Liang
  • Kinase inhibitor compounds
    Patent number: 8198276
    Abstract: Pyrimidinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as inflammatory diseases and certain types of cancer.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: June 12, 2012
    Assignee: Xcovery Holding Company LLC
    Inventor: Congxin Liang
  • PI3K/MTOR KINASE INHIBITORS
    Publication number: 20110281857
    Abstract: 6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidine and 2-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidine derivatives have unexpected drug properties as inhibitors of PI3 and/or mTOR kinases and are useful in treating disorders related to abnormal PI3K/mTOR activities such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders.
    Type: Application
    Filed: November 11, 2009
    Publication date: November 17, 2011
    Applicant: XCOVERY HOLDING COMPANY, LLC
    Inventors: Congxin Liang, Zhigang Li