Abstract: Systems and Methods for Differential Pressure Determination and Control are disclosed. In one aspect, embodiments of the present disclosure include a system, which able to obtain pressure measurements. The system can include, a sensor and a processor coupled to the sensor. A further embodiment includes memory coupled to the processor where the memory has stored thereon instructions, which when executed by the processor, cause the processor to: determine, a local set of pressure measurements from the sensor and/or compare the local set of pressure measurements with an external set of pressure measurements.