Abstract: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.

Abstract: Methods of diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring autoimmune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.

Abstract: Described herein is a system for monitoring gene expression for diagnosing and monitoring inflammation disorders, and for monitoring gene expression in inflammation disorders in response to a particular drug treatment regimen. This system for detecting nucleic acid expression in a body fluid uses an isolated polynucleotide to detect expression of a nucleic acid comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 5; SEQ ID NO:11; SEQ ID NO:17; and SEQ ID NO: 23. These nucleic acids are differentially expressed in body fluid in an individual with a disease criterion for a disease as listed in Table 1 as compared to an individual without the disease criterion.

Abstract: The invention presents a method of diagnosing or monitoring the status of systemic lupus erythematosus (SLE) in a subject or patient comprising detecting the expression of all genes of a diagnostic set in the subject or patient wherein the diagnostic set comprises two or more genes having expression correlated with the classification or status of SLE; and diagnosing or monitoring the status of SLE in the subject or patient by applying at least one statistical method to the expression of the genes of the diagnostic set.

Abstract: Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection or cytomegalovirus infection and kits or systems containing the same are also described.

Abstract: Methods of diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis and kits or systems containing the same are also described.

Abstract: A vapor compression system (10) including an evaporator (16), a compressor (12), and a condenser (14) interconnected in a closed-loop system. In one embodiment, a multifunctional valve (18) is configured to receive a liquefied heat transfer fluid from the condenser (14) and a hot vapor from the compressor (12). A saturated vapor line (28) connects the outlet of the evaporator (16) and is sized so as to substantially convert the heat transfer fluid exiting the multifunctional valve (18) into a saturated vapor prior to delivery to the evaporator (16). The multifunctional valve (18) regulates the flow of heat transfer fluid by monitoring the temperature of the heat transfer fluid returning to the compressor (12) through a suction line (30) coupling the evaporator (16) outlet to the compressor (12) inlet. In one preferred embodiment, a bifurcated liquid line connects the condenser (14) outlet to the first inlet of an multifunctional valve and the inlet of a metering unit.

Abstract: Flow-regulating members are described that include a primary channel and a plurality of secondary channels. The primary channel defines a primary channel orifice in the flow-regulating member and the plurality of secondary channels define a plurality of secondary channel orifices in the flow-regulating member. The plurality of secondary channel orifices are located along a common periphery of the flow-regulating member, such that an axis passing through the primary channel orifice intersects a plane containing the common periphery at a unique point. At least two of the plurality of secondary channel orifices have different cross-sectional areas. At least one of the plurality of secondary channels intersects the primary channel. Expansion devices containing these flow-regulating members are also described, as are vapor compression systems containing expansion devices, and methods of operating vapor compression systems.

Abstract: A vapor compression refrigeration and freezer system includes a compressor, a condenser, an expansion devise and an evaporator which includes an evaporator coil having an inlet and an outlet which coil is in heat exchange relation with an air medium along substantially the entire coil length. The inlet to the evaporator coil is in flow communication with an outlet of the expansion devise via an evaporator feedline.

Abstract: A vapor compression system includes an evaporator, a compressor, and a condenser interconnected in a closed-loop system. In one embodiment, a multifunctional valve is configured to receive a liquefied heat transfer fluid from the condenser and a hot vapor from the compressor. A saturated vapor line connects the outlet of the multifunctional valve to the inlet of the evaporator and is sized so as to substantially convert the heat transfer fluid exiting the multifunctional valve into a saturated vapor prior to delivery to the evaporator. The multifunctional valve regulates the flow of heat transfer fluid through the valve by monitoring the temperature of the heat transfer fluid returning to the compressor through a suction line coupling the outlet of the evaporator to the inlet of the compressor.