Abstract: The disclosure lies in the field of regenerative medicine and relates to an implant having a matrix material, and a method for manufacturing an implant having matrix material. The disclosure further relates to a crimped implant.
Inventors:
Tom Lavrijsen, Anandkumar Nandakumar, Martijn Antonius Johannes Cox, Franciscus Petrus Thomas Baaijens, Anton Bosman, Carolina Victoria Catharina Bouten, Tristan Mes, Patricia Yvonne Wilhelmina Dankers, Serge Hendrikus Mathijs Söntjens, Henricus Marie Janssen
Abstract: A method of using a fluorinated polymer having a glass transition temperature below 40 C as a contrast agent in 19F magnetic resonance imaging (MRI) of a solid object, said solid object comprising said contrast agent. The invention relates to a solid object comprising a structural component and an imaging component, wherein the imaging component is at least one fluorinated polymer. The invention relates to a method for 19F MRI in solid state using a contrast agent comprising a fluorinated polymer as well as a method for in vivo visualizing a scaffold. It further relates to a method for in vivo monitoring the degradation of a solid object in time, wherein the degradation is monitored in time by using 19F MRI to visualize the solid object, and wherein the amount of degradation of the solid object is determined based on the decrease in the visibility of the amount of 19F.
Inventors:
Aurelie Brizard, Emial Pesters, Dirk Jan Broer, Rudolf Mathias Johannes Nicolaas Lamariche, Anton William Bosman, Henricus Marie Janssen, Serge Hendrikus Mathÿs Söntjens