Patents Assigned to Xencor
  • Protein design automation for protein libraries
    Patent number: 7379822
    Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: May 27, 2008
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Jöerg Bentzien, Klaus M. Fiebig
  • Protein design automation for protein libraries
    Patent number: 7315786
    Abstract: The invention relates to the use of protein design automation (P DA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: January 1, 2008
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Jörg Bentzien, Klaus M. Fiebig, Robert J. Hayes
  • TNF-alpha VARIANTS PROTEINS FOR THE TREATMENT OF TNF-alpha RELATED DISORDERS
    Publication number: 20070207961
    Abstract: The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
    Type: Application
    Filed: March 29, 2007
    Publication date: September 6, 2007
    Applicant: Xencor
    Inventors: Bassil Dahiyat, John Desjarlais, Anton Filikov, Umesh Muchhal, Malu Tansey, Jonathan Zalevsky
  • TNF-alpha variants proteins for the treatment of TNF-alpha related disorders
    Patent number: 7244823
    Abstract: The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: July 17, 2007
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, John R. Desjarlais, Anton Filikov, Umesh Muchhal, Malu Lourdes G. Tansey, Jonathan Zalevsky
  • Protein based tumor necrosis factor-receptor variants for the treatment of TNF related disorders
    Patent number: 7144987
    Abstract: The invention relates to novel proteins with TNF-receptor antagonist activity and nucleic acids encoding these proteins. The invention further relates to TNF-receptor proteins with reduced immunogenicity and the use of these novel proteins in the treatment of TNF related disorders.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: December 5, 2006
    Assignee: Xencor
    Inventors: Arthur J. Chirino, Peizhi Luo, Peter Colon McDonnell, Umesh Muchhal, Malu Lourdes Tansey
  • TNF-?variants
    Patent number: 7101974
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: September 5, 2006
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • TNF-? variants
    Patent number: 7056695
    Abstract: The invention relates to novel proteins with TNF-? antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-? related disorders, such as rheumatoid arthritis.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 6, 2006
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Anton Filikov
  • BMP-7 variants with improved properties
    Publication number: 20060058231
    Abstract: The invention relates to variants of BMP-7 with improved properties and methods for their use.
    Type: Application
    Filed: March 31, 2005
    Publication date: March 16, 2006
    Applicant: Xencor
    Inventors: John Desjarlais, Shannon Marshall, Jonathan Zalevsky
  • Structure-based screening techniques for drug discovery
    Patent number: 6864359
    Abstract: The invention relates to novel non-naturally occurring cell surface receptor analogs, ligand analogs and nucleic acids encoding them. The invention further provides methods for screening of ligand analogs and bioactive agents capable of modulating the signaling activity of a non-naturally occurring cell surface receptor analog or capable of binding to a non-naturally occurring cell surface receptor analog.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: March 8, 2005
    Assignee: Xencor
    Inventor: Peizhi Luo
  • Methods for rational pegylation of proteins
    Publication number: 20040249576
    Abstract: The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method.
    Type: Application
    Filed: March 31, 2004
    Publication date: December 9, 2004
    Applicant: Xencor
    Inventors: John Rudolph Desjarlais, Jonathan Zalevsky
  • Novel proteins with altered immunogenicity
    Publication number: 20040230380
    Abstract: The present invention provides methods for combining computational methods for modulating protein immunogenicity with computational methods for identifying sequences with desired structural and functional properties. More specifically, the methods of the present invention may be used to identify modifications that increase or decrease the immunogenicity of a protein by affecting antigen uptake, MHC binding, T-cell binding, or antibody binding, while retaining or enhancing functional properties.
    Type: Application
    Filed: January 8, 2004
    Publication date: November 18, 2004
    Applicant: Xencor
    Inventors: Arthur J. Chirino, Bassil I. Dahiyat, John Rudolph Desjarlais, Shannon Alicia Marshall
  • Interferon variants with improved properties
    Publication number: 20040137581
    Abstract: The invention relates to interferon variants with improved properties and methods for their use.
    Type: Application
    Filed: September 30, 2003
    Publication date: July 15, 2004
    Applicant: Xencor
    Inventors: Anna Marie Aguinaldo, Amelia Joy Beyna, Ho Sung Cho, John Rudolph Desjarlais, Shannon Alicia Marshall, Umesh Muchhal, Michael Francis Aquino Villegas, Eugene Zhukovsky
  • Optimized Fc variants and methods for their generation
    Publication number: 20040132101
    Abstract: The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
    Type: Application
    Filed: September 26, 2003
    Publication date: July 8, 2004
    Applicant: Xencor
    Inventors: Gregory Alan Lazar, Arthur J. Chirino, Wei Dang, John Rudolph Desjarlais, Stephen Kohl Doberstein, Robert J. Hayes, Sher Bahadur Karki, Omid Vafa
  • Antibody optimization
    Publication number: 20040110226
    Abstract: The present invention relates to the use of computational screening methods to optimize the physico-chemical properties of antibodies, including stability, solubility, and antigen binding affinity.
    Type: Application
    Filed: March 3, 2003
    Publication date: June 10, 2004
    Applicant: Xencor
    Inventors: Gregory Alan Lazar, John Rudolf Desjarlais, Shannon Alicia Marshall, Bassil I. Dahiyat
  • Thermostable alkaliphilic xylanase
    Patent number: 6682923
    Abstract: The invention relates to novel xylanase activity (XA) proteins and nucleic acids. The invention further relates to the use of the XA proteins in the process of pulp bleaching.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 27, 2004
    Assignee: Xencor
    Inventors: Jörg Bentzien, Bassil I. Dahiyat
  • Nucleic acids and protein variants of hG-CSF with granulopoietic activity
    Patent number: 6627186
    Abstract: The invention relates to novel granulopoietic activity (GPA) proteins and nucleic acids. The invention further relates to the use of the GPA proteins in the treatment of G-CSF related disorders.
    Type: Grant
    Filed: January 6, 2000
    Date of Patent: September 30, 2003
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Peizhi Luo
  • Protein design automation for protein libraries
    Publication number: 20030049654
    Abstract: The invention relates to the use of protein design automation (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Application
    Filed: March 18, 2002
    Publication date: March 13, 2003
    Applicant: XENCOR
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Jorg Bentzien, Klaus M. Fiebig
  • Protein design automatic for protein libraries
    Patent number: 6403312
    Abstract: The invention relates to the use of protein design automaton (PDA) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: June 11, 2002
    Assignee: Xencor
    Inventors: Bassil I. Dahiyat, Robert J. Hayes, Jörg Bentzien, Klaus M. Fiebig